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Impdh1 Gene Detail
Summary
  • Symbol
    Impdh1
  • Name
    inosine monophosphate dehydrogenase 1
  • Synonyms
    B930086D20Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:96567
    NCBI Gene: 23917
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:29200435-29216363 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 12.36 cM, cytoband A3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    346 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96567
 protein coding gene Chr6:29200433-29216363 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030516
 protein coding gene Chr6:26970882-26986824 (-)
A/J MGP_AJ_G0030489
 protein coding gene Chr6:25832774-25848695 (-)
AKR/J MGP_AKRJ_G0030416
 protein coding gene Chr6:26694073-26710040 (-)
BALB/cJ MGP_BALBcJ_G0030499
 protein coding gene Chr6:25990847-26007738 (-)
C3H/HeJ MGP_C3HHeJ_G0030212
 protein coding gene Chr6:26686213-26703031 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030953
 protein coding gene Chr6:27758580-27774490 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028164
 protein coding gene Chr6:24050982-24066600 (-)
CAST/EiJ MGP_CASTEiJ_G0029614
 protein coding gene Chr6:26468416-26485752 (-)
CBA/J MGP_CBAJ_G0030190
 protein coding gene Chr6:28771506-28787413 (-)
DBA/2J MGP_DBA2J_G0030334
 protein coding gene Chr6:25778726-25795883 (-)
FVB/NJ MGP_FVBNJ_G0030288
 protein coding gene Chr6:25532047-25547879 (-)
LP/J MGP_LPJ_G0030421
 protein coding gene Chr6:27111152-27128349 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030324
 protein coding gene Chr6:31312945-31328852 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030983
 protein coding gene Chr6:26549888-26567960 (-)
PWK/PhJ MGP_PWKPhJ_G0029328
 protein coding gene Chr6:25312067-25327945 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029164
 protein coding gene Chr6:26279699-26301524 (-)
WSB/EiJ MGP_WSBEiJ_G0029690
 protein coding gene Chr6:26524467-26542683 (-)



Homology
more
  • Human Ortholog
    IMPDH1, inosine monophosphate dehydrogenase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IMPDH1, inosine monophosphate dehydrogenase 1
  • Synonyms
    IMPD, IMPD1, IMPDH-I, LCA11, RP10, sWSS2608
  • Links
    NCBI Gene ID: 3614
    neXtProt AC: NX_P20839
    UniProt: P20839

  • Chr Location
    7q32.1; chr7:128392277-128409986 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human IMPDH1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mic homozygous for disruptions of this gene display abnormalities in T cell proliferation. Mice homozygous for an ENU-induced mutation exhibit reduced thickness of the outer nuclear layer and total retina thickness.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    2
  • cDNA Data
    7
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 23917 NCBI Gene Model | MGI Sequence Detail 15929 C57BL/6J ±  kb
    transcript NM_001302933 RefSeq | MGI Sequence Detail 2620 Not Specified  
    polypeptide P50096 UniProt | EBI | MGI Sequence Detail 514 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 8
      cDNA 8

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11401, MGI:2444863
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:308551 Astrin KH, et al., Mutants of purine metabolism in cultured mouse and hamster cells. Arch Biochem Biophys. 1976 Oct;176(2):397-410
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory