Inha MGI Mouse Gene Detail - MGI:96569

Symbol

Inha
Name

inhibin alpha

Feature Type

protein coding gene
IDs

MGI:96569
NCBI Gene: 16322
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr1:75483872-75487010 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 39.16 cM, cytoband C5
Mapping Data

23 experiments

SNPs within 2kb

140 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96569	protein coding gene	Chr1:75483721-75487010 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016192	protein coding gene	Chr1:76086481-76089769 (+)
A/J	MGP_AJ_G0016175	protein coding gene	Chr1:73432401-73435690 (+)
AKR/J	MGP_AKRJ_G0016132	protein coding gene	Chr1:75469092-75472379 (+)
BALB/cJ	MGP_BALBcJ_G0016130	protein coding gene	Chr1:73494299-73497588 (+)
C3H/HeJ	MGP_C3HHeJ_G0015961	protein coding gene	Chr1:75798166-75801455 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016583	protein coding gene	Chr1:79040653-79043942 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014304	protein coding gene	Chr1:68990250-68993789 (+)
CAST/EiJ	MGP_CASTEiJ_G0015545	protein coding gene	Chr1:75144986-75148283 (+)
CBA/J	MGP_CBAJ_G0015934	protein coding gene	Chr1:81623578-81626867 (+)
DBA/2J	MGP_DBA2J_G0016035	protein coding gene	Chr1:72750448-72753736 (+)
FVB/NJ	MGP_FVBNJ_G0016038	protein coding gene	Chr1:71958189-71961475 (+)
LP/J	MGP_LPJ_G0016107	protein coding gene	Chr1:77214221-77217509 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016058	protein coding gene	Chr1:84955737-84959023 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016630	protein coding gene	Chr1:75535534-75538822 (+)
PWK/PhJ	MGP_PWKPhJ_G0015332	protein coding gene	Chr1:72226938-72230227 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015110	protein coding gene	Chr1:74891155-74894463 (+)
WSB/EiJ	MGP_WSBEiJ_G0015607	protein coding gene	Chr1:75346020-75349308 (+)

Human Ortholog

INHA, inhibin subunit alpha

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

INHA, inhibin subunit alpha
Links

HGNC:6065

NCBI Gene ID: 3623

neXtProt AC: NX_P05111

UniProt: P05111
Chr Location

2q35; chr2:219569162-219575711 (+) GRCh38

MGI Vertebrate Homology

Inha stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: INHA
Protein SuperFamily

Inhibin_alpha_subunit
Gene Tree

Inha

Diseases

1 with human INHA associations

				Human Disease	Mouse Models
				prostate carcinoma IDs prostate carcinoma DOID:10286 EFO:0001663 KEGG:05215 NCI:C4863 UMLS_CUI:C0600139

Click on a disease name to see all genes associated with that disease.

References

1 with disease annotations

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Phenotype Summary

40 phenotypes from 2 alleles in 4 genetic backgrounds
31 phenotypes from multigenic genotypes
2 images
70 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

6
Radiation induced

2
Spontaneous

1
Targeted

1
Genomic Mutations

4 involving Inha
Incidental Mutations

APF
Find Mice (IMSR)

9 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mutant mice develop gonadal sex cord-stromal tumors with nearly 100% penetrance and develop cachexia-like symptoms. The wasting syndrome is not observed in gonadectomized mutant mice, which develop adrenal tumors. Homozygous inhibition of inhibin activity leads to increased ovulation but reduced embryo/fetal/newborn survival of offspring of affected mothers, while heterozygote mothers show increased fecundity.

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All GO Annotations

38
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

833
Tissues

86
cDNA Data

33
Literature Summary

33

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase inha

ZFIN inha

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All Sequences

38
RefSeq

6
UniProt

1
CCDS

CCDS15078.1

Ensembl

ENSMUSG00000032968 (Evidence)
NCBI Gene

16322

			Length	Strain/Species	Flank
genomic	16322	NCBI Gene Model \| MGI Sequence Detail	3139	C57BL/6J	± kb
transcript	NM_001329843	RefSeq \| MGI Sequence Detail	2275	ZRU/MplStud
polypeptide	Q04997	UniProt \| EBI \| MGI Sequence Detail	366	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001730 inhibin alpha chain

(term hierarchy)
InterPro Domains

IPR029034 Cystine-knot cytokine

IPR017175 Inhibin, alpha subunit

IPR017948 Transforming growth factor beta, conserved site

IPR001839 Transforming growth factor-beta, C-terminal

IPR015615 Transforming growth factor-beta-related
GlyGen

Q04997 2 sites

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All nucleic 50

Genomic 3

cDNA 38

Primer pair 5

Other 4

Microarray probesets 3

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MGD-MRK-11406, MGI:2138616

Summaries

All 169

Developmental Gene Expression 33

Diseases 1

Gene Ontology 7

Phenotypes 70
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:342617 Dali O, et al., Transgenerational epigenetic effects imposed by neonicotinoid thiacloprid exposure. Life Sci Alliance. 2024 Feb;7(2)

TSS for Inha:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr7541	Chr1:75482233-75482272 (+)	-1,619 bp
Tssr7542	Chr1:75482273-75482319 (+)	-1,576 bp
Tssr7543	Chr1:75482382-75482393 (+)	-1,484 bp
Tssr7544	Chr1:75483811-75483828 (+)	-52 bp
Tssr7545	Chr1:75483834-75483845 (+)	-32 bp
Tssr7546	Chr1:75483863-75483888 (+)	4 bp
Tssr7547	Chr1:75484058-75484099 (+)	207 bp
Tssr7548	Chr1:75486391-75486413 (+)	2,530 bp
Tssr7549	Chr1:75486676-75486678 (+)	2,805 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24