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Ins1 Gene Detail
Summary
  • Symbol
    Ins1
  • Name
    insulin I
  • Feature Type
    protein coding gene
  • IDs
    MGI:96572
    NCBI Gene: 16333
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
  • Candidate for QTL
    6 QTL
Location &
Maps
more
  • Sequence Map
    Chr19:52252735-52253453 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 46.76 cM
  • Mapping Data
    22 experiments
Strain
Comparison
more
  • SNPs within 2kb
    140 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    5
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96572
 protein coding gene Chr19:52252735-52253914 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025241
 protein coding gene Chr19:52345404-52346535 (+)
A/J MGP_AJ_G0025217
 protein coding gene Chr19:49739360-49740493 (+)
AKR/J MGP_AKRJ_G0025186
 protein coding gene Chr19:51340466-51341599 (+)
BALB/cJ MGP_BALBcJ_G0025212
 protein coding gene Chr19:49822308-49823441 (+)
C3H/HeJ MGP_C3HHeJ_G0024972
 protein coding gene Chr19:51498788-51499921 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025655
 protein coding gene Chr19:53601834-53602967 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023067
 protein coding gene Chr19:48769063-48770197 (+)
CAST/EiJ MGP_CASTEiJ_G0024436
 protein coding gene Chr19:51440203-51441340 (+)
CBA/J MGP_CBAJ_G0024952
 protein coding gene Chr19:56208275-56209408 (+)
DBA/2J MGP_DBA2J_G0025084
 protein coding gene Chr19:49552933-49554066 (+)
FVB/NJ MGP_FVBNJ_G0025045
 protein coding gene Chr19:49266656-49267789 (+)
LP/J MGP_LPJ_G0025170
 protein coding gene Chr19:52167683-52168814 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025076
 protein coding gene Chr19:55736242-55737375 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025713
 protein coding gene Chr19:51482819-51483952 (+)
PWK/PhJ MGP_PWKPhJ_G0024185
 protein coding gene Chr19:49456867-49458003 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023988
 protein coding gene Chr19:50177911-50179040 (+)
WSB/EiJ MGP_WSBEiJ_G0024507
 protein coding gene Chr19:51626851-51627984 (+)



Homology
more
  • Human Ortholog
    INS, insulin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INS, insulin
  • Synonyms
    IDDM, IDDM1, IDDM2, ILPR, IRDN, MODY10, PNDM4
  • Links
    NCBI Gene ID: 3630
    neXtProt AC: NX_P01308
    UniProt: P01308

  • Chr Location
    11p15.5; chr11:2159779-2161221 (-)  GRCh38
Human Diseases
more
  • Diseases
    10 with human INS associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
 View 1 model
IDs
 View 6 models
IDs
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 3 genetic backgrounds
    40 phenotypes from multigenic genotypes
    3 images
    139 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have a somewhat increased pancreatic beta cell mass and a limited amount of hyperplasia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1316
  • Tissues
    99
  • cDNA Data
    105
  • Literature Summary
    506
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16333 NCBI Gene Model | MGI Sequence Detail 719 C57BL/6J ±  kb
transcript NM_008386 RefSeq | MGI Sequence Detail 611 ZRU/MplStud  
polypeptide P01325 UniProt | EBI | MGI Sequence Detail 108 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 134
    Genomic 1
    cDNA 106
    Primer pair 21
    Other 6

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-11410, MGD-MRK-11413, MGD-MRK-11415
References
more
  • Summaries
    All 779
    Developmental Gene Expression 506
    Diseases 4
    Gene Ontology 13
    Phenotypes 139
  • Earliest
    J:4914 Lalley PA, et al., Mapping of mouse insulin genes (Abstracts of meeting presentations: Human gene mapping 7, Los Angeles Conference (1983) Seventh International Workshop on Human Gene Mapping). Cytogenet Cell Genet. 1984;37 (1-4):515 (Abstr.) (399-616)
  • Latest
    J:355694 Davidson RK, et al., The SWI/SNF chromatin remodelling complex regulates pancreatic endocrine cell expansion and differentiation in mice in vivo. Diabetologia. 2024 Oct;67(10):2275-2288
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory