Ir2 Gene Detail

Summary

• Symbol
  Ir2
• Name
  immune response 2
• Synonyms
  Ir-2

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:96584
  NCBI Gene: 109687
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 2, Syntenic
• Mapping Data
  5 experiments

Mutations,
Alleles, and
Phenotypes

This locus controls ability to produce agglutinating antibodies to Ea1 antigens in crosses between YBR strain (b allele causing non-responsiveness) and either BALB or CBA (a allele causing responsiveness). Ir2 is unusual in that responsiveness is recessive.

Sequences &
Gene Models

• NCBI Gene
  109687

Other
Accession IDs

MGD-MRK-11448, MGD-MRK-11456

References

• Summaries
  All 9
• Earliest
  J:5119 Gasser DL, Genetic control of the immune response in mice. I. Segregation data and localization to the fifth linkage group of a gene affecting antibody production. J Immunol. 1969 Jul;103(1):66-70
• Latest
  J:94125 Rhee SD, et al., Fine localization of Nefl and Nef3 and its exclusion as candidate gene for lens rupture 2(lr2). Exp Anim. 2004 Jul;53(4):295-301