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Irf2 Gene Detail
Summary
  • Symbol
    Irf2
  • Name
    interferon regulatory factor 2
  • Synonyms
    9830146E22Rik, Irf-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96591
    NCBI Gene: 16363
  • Alliance
    gene page
  • Transcription Start Sites
    40 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:47192767-47300493 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 26.42 cM, cytoband B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3377 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96591
 protein coding gene Chr8:47192751-47300493 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033592
 protein coding gene Chr8:45862532-45979117 (+)
A/J MGP_AJ_G0033574
 protein coding gene Chr8:44093514-44203846 (+)
AKR/J MGP_AKRJ_G0033499
 protein coding gene Chr8:45378866-45487537 (+)
BALB/cJ MGP_BALBcJ_G0033571
 protein coding gene Chr8:44264391-44373019 (+)
C3H/HeJ MGP_C3HHeJ_G0033280
 protein coding gene Chr8:45911511-46026537 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034087
 protein coding gene Chr8:47591795-47708659 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031036
 protein coding gene Chr8:40329948-40437791 (+)
CAST/EiJ MGP_CASTEiJ_G0032606
 protein coding gene Chr8:45356842-45475206 (+)
CBA/J MGP_CBAJ_G0033259
 protein coding gene Chr8:49496730-49624885 (+)
DBA/2J MGP_DBA2J_G0033412
 protein coding gene Chr8:43887995-43996148 (+)
FVB/NJ MGP_FVBNJ_G0033353
 protein coding gene Chr8:43363652-43470417 (+)
LP/J MGP_LPJ_G0033500
 protein coding gene Chr8:45868874-45983843 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033398
 protein coding gene Chr8:49577761-49695421 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034105
 protein coding gene Chr8:45541864-45653025 (+)
PWK/PhJ MGP_PWKPhJ_G0032314
 protein coding gene Chr8:43410935-43520472 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032150
 protein coding gene Chr8:44708572-44823102 (+)
WSB/EiJ MGP_WSBEiJ_G0032722
 protein coding gene Chr8:45802306-45919690 (+)



Homology
more
  • Human Ortholog
    IRF2, interferon regulatory factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IRF2, interferon regulatory factor 2
  • Synonyms
    IRF-2
  • Links
    NCBI Gene ID: 3660
    neXtProt AC: NX_P14316
    UniProt: P14316

  • Chr Location
    4q35.1; chr4:184385702-184474558 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormalities in B lymphopoiesis and hematopoiesis, often die prematurely, show increased mortality following lymphocytic choriomeningitis virus infection, and develop an inflammatory skin disease involving CD8+ Tcells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    4
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    747
  • Tissues
    27
  • cDNA Data
    40
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031627 Ensembl Gene Model | MGI Sequence Detail 107727 C57BL/6J ±  kb
    transcript ENSMUST00000034041 Ensembl | MGI Sequence Detail 2497 Not Applicable  
    polypeptide ENSMUSP00000034041 Ensembl | MGI Sequence Detail 349 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 42
      cDNA 41
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-11466, MGI:2142602, MGI:2443654
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 5
      Gene Ontology 4
      Phenotypes 36
    • Earliest
      J:17557 Harada H, et al., Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. Cell. 1989 Aug 25;58(4):729-39
    • Latest
      J:333822 Lukhele S, et al., The transcription factor IRF2 drives interferon-mediated CD8(+) T cell exhaustion to restrict anti-tumor immunity. Immunity. 2022 Dec 13;55(12):2369-2385.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory