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Itga1 Gene Detail
Summary
  • Symbol
    Itga1
  • Name
    integrin alpha 1
  • Synonyms
    CD49A, E130012M19Rik, Vla1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96599
    NCBI Gene: 109700
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:115094615-115238500 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 64.61 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5442 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96599
 protein coding gene Chr13:115089632-115238500 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020959
 protein coding gene Chr13:117707112-117868022 (-)
A/J MGP_AJ_G0020909
 protein coding gene Chr13:112925709-113076535 (-)
AKR/J MGP_AKRJ_G0020884
 protein coding gene Chr13:116325002-116471272 (-)
BALB/cJ MGP_BALBcJ_G0020909
 protein coding gene Chr13:113648010-113797220 (-)
C3H/HeJ MGP_C3HHeJ_G0020698
 protein coding gene Chr13:116155957-116308153 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021345
 protein coding gene Chr13:121136839-121295330 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018914
 protein coding gene Chr13:108194682-108342535 (-)
CAST/EiJ MGP_CASTEiJ_G0020217
 protein coding gene Chr13:115829379-115991033 (-)
CBA/J MGP_CBAJ_G0020660
 protein coding gene Chr13:125765915-125938827 (-)
DBA/2J MGP_DBA2J_G0020783
 protein coding gene Chr13:112637214-112785238 (-)
FVB/NJ MGP_FVBNJ_G0020767
 protein coding gene Chr13:111285087-111432616 (-)
LP/J MGP_LPJ_G0020859
 protein coding gene Chr13:117696763-117849677 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020795
 protein coding gene Chr13:126038452-126194619 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021381
 protein coding gene Chr13:115816206-115973175 (-)
PWK/PhJ MGP_PWKPhJ_G0019970
 protein coding gene Chr13:111425023-111579731 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019792
 protein coding gene Chr13:112158742-112296723 (-)
WSB/EiJ MGP_WSBEiJ_G0020275
 protein coding gene Chr13:116451918-116606099 (-)



Homology
more
  • Human Ortholog
    ITGA1, integrin subunit alpha 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGA1, integrin subunit alpha 1
  • Synonyms
    CD49a, VLA1
  • Links
    NCBI Gene ID: 3672
    neXtProt AC: NX_P56199
    UniProt: P56199

  • Chr Location
    5q11.2; chr5:52787916-52959209 (+)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    18 phenotypes from multigenic genotypes
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are essentially normal although their kidneys are smaller and more succeptible to injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    725
  • Tissues
    13
  • cDNA Data
    38
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109700 NCBI Gene Model | MGI Sequence Detail 143886 C57BL/6J ±  kb
    transcript NM_001033228 RefSeq | MGI Sequence Detail 5984 ZRU/MplStud  
    polypeptide Q3V3R4 UniProt | EBI | MGI Sequence Detail 1179 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000001007 integrin alpha-1
      (term hierarchy)
    • InterPro Domains
      IPR050525 Extracellular Matrix Assembly and Organization
      IPR013517 FG-GAP repeat
      IPR013519 Integrin alpha beta-propellor
      IPR000413 Integrin alpha chain
      IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
      IPR013649 Integrin alpha, first immunoglubulin-like domain
      IPR028994 Integrin alpha, N-terminal
      IPR048285 Integrin alpha, second immunoglobulin-like domain
      IPR048286 Integrin alpha, third immunoglobulin-like domain
      IPR032695 Integrin domain superfamily
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR002035 von Willebrand factor, type A
    • GlyGen
      Q3V3R4 25 sites, 18 N-linked glycans (15 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 1
      cDNA 44
      Primer pair 2
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11478, MGD-MRK-19432, MGI:2444353
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 18
      Diseases 1
      Gene Ontology 15
      Phenotypes 37
    • Earliest
      J:10663 Eicher EM, et al., The NXSM recombinant inbred strains of mice: genetic profile for 58 loci including the Mtv proviral loci. Genetics. 1990 Jun;125(2):431-46
    • Latest
      J:334526 Ray AT, et al., FGF signaling regulates salivary gland branching morphogenesis by modulating cell adhesion. Development. 2023 Mar 15;150(6):dev201293
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory