Itgam MGI Mouse Gene Detail - MGI:96607

Symbol

Itgam
Name

integrin alpha M
Synonyms

Cd11b, CD11b/CD18, CD11B (p170), complement component receptor 3 alpha, complement receptor type 3, CR3, F730045J24Rik, Ly-40, Mac-1, Mac-1a, Mac-1 alpha

Feature Type

protein coding gene
IDs

MGI:96607
NCBI Gene: 16409
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr7:127661812-127717663 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 69.93 cM, cytoband F4
Mapping Data

3 experiments

SNPs within 2kb

1476 from dbSNP Build 142
Strain Annotations

18
PCR

2
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96607	protein coding gene	Chr7:127661812-127717663 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033070	protein coding gene	Chr7:132464519-132526061 (+)
A/J	MGP_AJ_G0033053	protein coding gene	Chr7:128908509-128963130 (+)
AKR/J	MGP_AKRJ_G0032985	protein coding gene	Chr7:132260880-132323867 (+)
BALB/cJ	MGP_BALBcJ_G0033054	protein coding gene	Chr7:128567456-128627107 (+)
C3H/HeJ	MGP_C3HHeJ_G0032768	protein coding gene	Chr7:132153468-132215646 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033564	protein coding gene	Chr7:137621345-137685831 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030536	protein coding gene	Chr7:130090750-130145490 (+)
CAST/EiJ	MGP_CASTEiJ_G0032097	protein coding gene	Chr7:123945852-124004522 (+)
CBA/J	MGP_CBAJ_G0032741	protein coding gene	Chr7:142304584-142374775 (+)
DBA/2J	MGP_DBA2J_G0032893	protein coding gene	Chr7:126891506-126945722 (+)
FVB/NJ	MGP_FVBNJ_G0032846	protein coding gene	Chr7:126749290-126810905 (+)
LP/J	MGP_LPJ_G0032987	protein coding gene	Chr7:133934814-133996034 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032878	protein coding gene	Chr7:143369067-143429668 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033583	protein coding gene	Chr7:131238709-131297422 (+)
PWK/PhJ	MGP_PWKPhJ_G0031804	protein coding gene	Chr7:119895228-119952819 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031650	protein coding gene	Chr7:118047935-118098342 (+)
WSB/EiJ	MGP_WSBEiJ_G0032209	protein coding gene	Chr7:132206824-132269089 (+)

Human Ortholog

ITGAM, integrin subunit alpha M

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ITGAM, integrin subunit alpha M
Synonyms

CD11B, CR3A, MAC-1, MAC1A, MO1A, SLEB6
Links

HGNC:6149

NCBI Gene ID: 3684

neXtProt AC: NX_P11215

UniProt: P11215
Chr Location

16p11.2; chr16:31259967-31332892 (+) GRCh38

MGI Vertebrate Homology

Itgam stringent orthology
1 human;1 mouse;2 zebrafish
HCOP

vertebrate homology predictions: ITGAM
Gene Tree

Itgam

Diseases

3 with human ITGAM associations

				Human Disease	Mouse Models
				lupus nephritis IDs lupus nephritis DOID:0080162 MESH:D008181
				persistent fetal circulation syndrome IDs persistent fetal circulation syndrome DOID:13042 ICD10CM:P29.3 ICD9CM:747.83 MESH:D010547 NCI:C85006 OMIM:265380 UMLS_CUI:C0031190
				pre-eclampsia IDs pre-eclampsia DOID:10591 DOID:12684 ICD10CM:O14 MESH:D011225 NCI:C85021 OMIM:189800 OMIM:609402 OMIM:609403 OMIM:609404 OMIM:614592 ORDO:275555 UMLS_CUI:C0032914

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

31 phenotypes from 7 alleles in 11 genetic backgrounds
1 phenotype from multigenic genotypes
234 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Chemically induced (ENU)

3
Endonuclease-mediated

6
Gene trapped

1
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

48 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Homozygous null mice exhibit reduced staphylococcal enterotoxin-induced T cell proliferation, reduced neutrophil adhesion to fibrinogen, and defective homotypic aggregation and reduced degranulation of neutrophils.

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All GO Annotations

61
GO References

37

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

767
Tissues

32
cDNA Data

38
Literature Summary

88

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

53
RefSeq

4
UniProt

1
CCDS

CCDS21889.1, CCDS40149.1

Ensembl

ENSMUSG00000030786 (Evidence)
NCBI Gene

16409

			Length	Strain/Species	Flank
genomic	16409	NCBI Gene Model \| MGI Sequence Detail	55852	C57BL/6J	± kb
transcript	NM_001082960	RefSeq \| MGI Sequence Detail	4682	C57BL/6
polypeptide	P05555	UniProt \| EBI \| MGI Sequence Detail	1153	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000001012 integrin alpha-M

(term hierarchy)
GlyGen

P05555 16 sites, 6 N-linked glycans (8 sites)

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All nucleic 48

Genomic 3

cDNA 38

Primer pair 7

Microarray probesets 3

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MGD-MRK-11486, MGD-MRK-11982, MGD-MRK-12094, MGI:2444489

Summaries

All 481

Developmental Gene Expression 88

Gene Ontology 37

Phenotypes 234
Earliest

J:6186 Springer T, et al., Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol. 1979 Apr;9(4):301-6
Latest

J:354496 Stark K, et al., Antibodies and complement are key drivers of thrombosis. Immunity. 2024 Sep 10;57(9):2140-2156.e10

TSS for Itgam:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr69335	Chr7:127661807-127661818 (+)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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