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Itgam Gene Detail
Summary
  • Symbol
    Itgam
  • Name
    integrin alpha M
  • Synonyms
    Cd11b, CD11b/CD18, CD11B (p170), complement component receptor 3 alpha, complement receptor type 3, CR3, F730045J24Rik, Ly-40, Mac-1, Mac-1a, Mac-1 alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:96607
    NCBI Gene: 16409
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:127661812-127717663 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 69.93 cM, cytoband F4
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1476 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96607
 protein coding gene Chr7:127661812-127717663 (+)
129S1/SvImJ ENSMUSG00200021503
 protein coding gene Chr7:114176443-114231747 (+)
A/J ENSMUSG00195037883
 protein coding gene Chr7:118676463-118732392 (+)
AKR/J ENSMUSG00220015939
 protein coding gene Chr7:112130867-112186785 (+)
BALB/cJ ENSMUSG00180012120
 protein coding gene Chr7:115371710-115427624 (+)
C3H/HeJ ENSMUSG00175015818
 protein coding gene Chr7:116098558-116154470 (+)
C57BL/6NJ ENSMUSG00215028179
 protein coding gene Chr7:115371592-115427478 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030536
 protein coding gene Chr7:130090750-130145490 (+)
CAST/EiJ ENSTCUG00005047716
 protein coding gene Chr7:118611756-118667377 (+)
CBA/J ENSMUSG00210023051
 protein coding gene Chr7:115852622-115908449 (+)
DBA/2J ENSMUSG00185039100
 protein coding gene Chr7:120165436-120221305 (+)
FVB/NJ ENSMUSG00205015428
 protein coding gene Chr7:115808526-115864399 (+)
JF1/MsJ no annotation
LP/J ENSMUSG00230051552
 protein coding gene Chr7:126276688-126335741 (+)
NOD/ShiLtJ ENSMUSG00190015173
 protein coding gene Chr7:116001744-116057586 (+)
NZO/HlLtJ ENSMUSG00225010979
 protein coding gene Chr7:124511801-124567708 (+)
PWK/PhJ ENSLUMG00010034748
 protein coding gene Chr7:114349369-114404684 (+)
SPRET/EiJ ENSMSPG00010011313
 protein coding gene Chr7:115605061-115661537 (+)
WSB/EiJ ENSIUOG00005025541
 protein coding gene Chr7:116702939-116758839 (+)



Homology
more
  • Human Ortholog
    ITGAM, integrin subunit alpha M
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGAM, integrin subunit alpha M
  • Synonyms
    CD11B, CR3A, HNA-4, MAC-1, MAC1A, MO1A, SLEB6
  • Links
    NCBI Gene ID: 3684
    UniProt: P11215

  • Chr Location
    16p11.2; chr16:31259967-31332892 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human ITGAM associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    31 phenotypes from 7 alleles in 11 genetic backgrounds
    1 phenotype from multigenic genotypes
    254 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit reduced staphylococcal enterotoxin-induced T cell proliferation, reduced neutrophil adhesion to fibrinogen, and defective homotypic aggregation and reduced degranulation of neutrophils.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    39
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    686
  • Tissues
    48
  • cDNA Data
    38
  • Literature Summary
    93
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16409 NCBI Gene Model | MGI Sequence Detail 55852 C57BL/6J ±  kb
    transcript NM_001082960 RefSeq | MGI Sequence Detail 4682 C57BL/6  
    polypeptide P05555 UniProt | EBI | MGI Sequence Detail 1153 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      14 Sequences
    • Protein Ontology
      PR:000001012 integrin alpha-M
      (term hierarchy)
    • PDB
      6RHV, 9HLL
    • InterPro Domains
      IPR013517 FG-GAP repeat
      IPR013519 Integrin alpha beta-propellor
      IPR000413 Integrin alpha chain
      IPR018184 Integrin alpha chain, C-terminal cytoplasmic region, conserved site
      IPR013649 Integrin alpha, first immunoglubulin-like domain
      IPR028994 Integrin alpha, N-terminal
      IPR048285 Integrin alpha, second immunoglobulin-like domain
      IPR048633 Integrin alpha-X-like, third Ig-like domain
      IPR032695 Integrin domain superfamily
      IPR001854 Large ribosomal subunit protein uL29
      IPR036049 Large ribosomal subunit protein uL29 superfamily
      IPR036465 von Willebrand factor A-like domain superfamily
      IPR002035 von Willebrand factor, type A
    • GlyGen
      P05555 17 sites, 6 N-linked glycans (8 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 3
      cDNA 38
      Primer pair 7
      Antibodies 15

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11486, MGD-MRK-11982, MGD-MRK-12094, MGI:2444489
    References
    more
    • Summaries
      All 531
      Developmental Gene Expression 93
      Gene Ontology 39
      Phenotypes 254
    • Earliest
      J:6186 Springer T, et al., Mac-1: a macrophage differentiation antigen identified by monoclonal antibody. Eur J Immunol. 1979 Apr;9(4):301-6
    • Latest
      J:389881 Lin Y, et al., Integrin CD11b/CD18 reprograms macrophage polarization by suppressing ERK/STAT3 signaling to enhance antitumor immunity in colitis-associated colorectal cancer. J Immunother Cancer. 2026 Jun 18;14(6)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory