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Cd47 Gene Detail
Summary
  • Symbol
    Cd47
  • Name
    CD47 antigen (Rh-related antigen, integrin-associated signal transducer)
  • Synonyms
    9130415E20Rik, B430305P08Rik, IAP, integrin-associated protein, Itgp
  • Feature Type
    protein coding gene
  • IDs
    MGI:96617
    NCBI Gene: 16423
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:49671691-49732799 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 31.23 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1481 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96617
 protein coding gene Chr16:49620896-49735373 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022874
 protein coding gene Chr16:48739547-48806548 (+)
A/J MGP_AJ_G0022841
 protein coding gene Chr16:46601229-46662708 (+)
AKR/J MGP_AKRJ_G0022813
 protein coding gene Chr16:48156699-48218311 (+)
BALB/cJ MGP_BALBcJ_G0022841
 protein coding gene Chr16:46673057-46733475 (+)
C3H/HeJ MGP_C3HHeJ_G0022604
 protein coding gene Chr16:48226930-48288684 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023289
 protein coding gene Chr16:49991813-50054221 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020801
 protein coding gene Chr16:46680827-46740506 (+)
CAST/EiJ MGP_CASTEiJ_G0022130
 protein coding gene Chr16:48551841-48616952 (+)
CBA/J MGP_CBAJ_G0022577
 protein coding gene Chr16:51955997-52020372 (+)
DBA/2J MGP_DBA2J_G0022709
 protein coding gene Chr16:46339378-46399134 (+)
FVB/NJ MGP_FVBNJ_G0022684
 protein coding gene Chr16:46205063-46264677 (+)
LP/J MGP_LPJ_G0022776
 protein coding gene Chr16:48530375-48592005 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022702
 protein coding gene Chr16:51710136-51775214 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023304
 protein coding gene Chr16:48198325-48261941 (+)
PWK/PhJ MGP_PWKPhJ_G0021870
 protein coding gene Chr16:46683823-46745543 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021700
 protein coding gene Chr16:48021951-48088744 (+)
WSB/EiJ MGP_WSBEiJ_G0022175
 protein coding gene Chr16:48216629-48279941 (+)



Homology
more
  • Human Ortholog
    CD47, CD47 molecule
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD47, CD47 molecule
  • Synonyms
    IAP, MER6, OA3
  • Links
    NCBI Gene ID: 961
    neXtProt AC: NX_Q08722
    UniProt: Q08722

  • Chr Location
    3q13.12; chr3:108043091-108091862 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 1 allele in 5 genetic backgrounds
    7 phenotypes from multigenic genotypes
    128 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in a reduced CD3+ fraction of peripheral lymphocytes and inability to clear infection by E.coli. Mutant animals are otherwise normal in appearance, survival, and fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    943
  • Tissues
    87
  • cDNA Data
    17
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16423 NCBI Gene Model | MGI Sequence Detail 61109 C57BL/6J ±  kb
    transcript NM_001368416 RefSeq | MGI Sequence Detail 2710 C57BL/6  
    polypeptide Q61735 UniProt | EBI | MGI Sequence Detail 303 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 1
      cDNA 17
      Primer pair 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-11496, MGI:1918837, MGI:1925789, MGI:2146333, MGI:2146503, MGI:2146621
    References
    more
    • Summaries
      All 215
      Developmental Gene Expression 12
      Gene Ontology 12
      Phenotypes 128
    • Earliest
      J:3170 Morse HC 3rd, Genetic nomenclature for loci controlling surface antigens of mouse hemopoietic cells [published erratum appears in J Immunol 1993 Mar 15;150(6):2563]. J Immunol. 1992 Nov 15;149(10):3129-34
    • Latest
      J:361531 Jain A, et al., Nociceptor-immune interactomes reveal insult-specific immune signatures of pain. Nat Immunol. 2024 Jul;25(7):1296-1305
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory