Itk MGI Mouse Gene Detail - MGI:96621 - IL2 inducible T cell kinase

Symbol

Itk
Name

IL2 inducible T cell kinase
Synonyms

Emt, Tcsk, Tsk

Feature Type

protein coding gene
IDs

MGI:96621
NCBI Gene: 16428
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr11:46215977-46280342 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 27.75 cM
Mapping Data

6 experiments

SNPs within 2kb

2247 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96621	protein coding gene	Chr11:46215975-46280342 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0018192	protein coding gene	Chr11:45238981-45306515 (-)
A/J	MGP_AJ_G0018164	protein coding gene	Chr11:43503601-43568648 (-)
AKR/J	MGP_AKRJ_G0018129	protein coding gene	Chr11:44750447-44818999 (-)
BALB/cJ	MGP_BALBcJ_G0018133	protein coding gene	Chr11:43661257-43726199 (-)
C3H/HeJ	MGP_C3HHeJ_G0017947	protein coding gene	Chr11:44796375-44860990 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018587	protein coding gene	Chr11:46583740-46652304 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016242	protein coding gene	Chr11:41480708-41547004 (-)
CAST/EiJ	MGP_CASTEiJ_G0017510	protein coding gene	Chr11:44920027-44987068 (-)
CBA/J	MGP_CBAJ_G0017919	protein coding gene	Chr11:48763944-48831765 (-)
DBA/2J	MGP_DBA2J_G0018029	protein coding gene	Chr11:43247829-43313367 (-)
FVB/NJ	MGP_FVBNJ_G0018023	protein coding gene	Chr11:42924194-42989103 (-)
LP/J	MGP_LPJ_G0018101	protein coding gene	Chr11:45487679-45554259 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018047	protein coding gene	Chr11:50289729-50358429 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018626	protein coding gene	Chr11:44913474-44981074 (-)
PWK/PhJ	MGP_PWKPhJ_G0017290	protein coding gene	Chr11:43334605-43400113 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0017083	protein coding gene	Chr11:44730649-44797223 (-)
WSB/EiJ	MGP_WSBEiJ_G0017560	protein coding gene	Chr11:44613051-44681282 (-)

Human Ortholog

ITK, IL2 inducible T cell kinase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ITK, IL2 inducible T cell kinase
Synonyms

EMT, LPFS1, LYK, PSCTK2
Links

HGNC:6171

NCBI Gene ID: 3702

neXtProt AC: NX_Q08881

UniProt: Q08881
Chr Location

5q33.3; chr5:157142933-157255185 (+) GRCh38

MGI Vertebrate Homology

Itk stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ITK
Gene Tree

Itk

Diseases

1 with human ITK associations

				Human Disease	Mouse Models
				lymphoproliferative syndrome 1 IDs lymphoproliferative syndrome 1 DOID:0060707 ICD10CM:D47.9 OMIM:613011

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

39 phenotypes from 6 alleles in 11 genetic backgrounds
34 phenotypes from multigenic genotypes
90 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Chemically induced (ENU)

2
Chemically induced (other)

1
Endonuclease-mediated

5
Targeted

7
Genomic Mutations

1 involving Itk
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene display decreased percentages of CD4 and CD8 cells, increased percentage of B cells, impaired T cell receptor signaling, and increased susceptibility to Toxoplasma gondii infection.

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All GO Annotations

34
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

17
Literature Summary

1

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN itk

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All Sequences

59
RefSeq

10
UniProt

6
CCDS

CCDS24575.2, CCDS70168.1, CCDS70169.1

Ensembl

ENSMUSG00000020395 (Evidence)
NCBI Gene

16428

			Length	Strain/Species	Flank
genomic	ENSMUSG00000020395	Ensembl Gene Model \| MGI Sequence Detail	64366	C57BL/6J	± kb
transcript	ENSMUST00000109237	Ensembl \| MGI Sequence Detail	4268	Not Applicable
polypeptide	ENSMUSP00000104860	Ensembl \| MGI Sequence Detail	625	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000002111 tyrosine-protein kinase ITK/TSK

(term hierarchy)
PDB

1AWJ, 1LUI, 1LUK, 1LUM, 1LUN, 2ETZ, 2EU0, 2K79, 2K7A, 2RN8, 2RNA, 3S9K
EC

2.7.10.2
InterPro Domains

IPR043539 Grb2-like

IPR050198 Non-receptor tyrosine kinases involved in cell signaling

IPR011993 PH-like domain superfamily

IPR001849 Pleckstrin homology domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR000980 SH2 domain

IPR036860 SH2 domain superfamily

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR035583 Tyrosine-protein kinase ITK, SH3 domain

IPR042785 Tyrosine-protein kinase ITK/TSK, catalytic domain

IPR001562 Zinc finger, Btk motif

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All nucleic 24

Genomic 2

cDNA 21

Primer pair 1

Microarray probesets 5

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MGD-MRK-11504, MGD-MRK-14937

Summaries

All 151

Developmental Gene Expression 1

Gene Ontology 17

Phenotypes 90
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Itk:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr107611	Chr11:46280413-46280418 (-)	-74 bp
Tssr107610	Chr11:46280336-46280352 (-)	-2 bp
Tssr107609	Chr11:46280298-46280332 (-)	27 bp
Tssr107608	Chr11:46280281-46280294 (-)	54 bp
Tssr107607	Chr11:46280252-46280275 (-)	78 bp
Tssr107606	Chr11:46279376-46279415 (-)	946 bp
Tssr107605	Chr11:46277435-46277449 (-)	2,900 bp
Tssr107603	Chr11:46263230-46263270 (-)	17,092 bp
Tssr107602	Chr11:46254649-46254695 (-)	25,670 bp
Tssr107601	Chr11:46248857-46248858 (-)	31,484 bp
Tssr107600	Chr11:46217692-46217724 (-)	62,634 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24