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Jak2 Gene Detail
Summary
  • Symbol
    Jak2
  • Name
    Janus kinase 2
  • Synonyms
    C81284
  • Feature Type
    protein coding gene
  • IDs
    MGI:96629
    NCBI Gene: 16452
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:29229228-29290480 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 23.73 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1745 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96629
 protein coding gene Chr19:29229006-29290495 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025018
 protein coding gene Chr19:27695387-27758792 (+)
A/J MGP_AJ_G0024995
 protein coding gene Chr19:26298794-26364935 (+)
AKR/J MGP_AKRJ_G0024963
 protein coding gene Chr19:27254101-27315050 (+)
BALB/cJ MGP_BALBcJ_G0024994
 protein coding gene Chr19:26351185-26412729 (+)
C3H/HeJ MGP_C3HHeJ_G0024750
 protein coding gene Chr19:27230909-27295836 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025435
 protein coding gene Chr19:28470673-28534010 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022854
 protein coding gene Chr19:26277749-26340039 (+)
CAST/EiJ MGP_CASTEiJ_G0024220
 protein coding gene Chr19:27058761-27122582 (+)
CBA/J MGP_CBAJ_G0024728
 protein coding gene Chr19:29807916-29877360 (+)
DBA/2J MGP_DBA2J_G0024860
 protein coding gene Chr19:26260991-26322291 (+)
FVB/NJ MGP_FVBNJ_G0024822
 protein coding gene Chr19:26106603-26179652 (+)
LP/J MGP_LPJ_G0024945
 protein coding gene Chr19:27692690-27758903 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024849
 protein coding gene Chr19:29755613-29826431 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025490
 protein coding gene Chr19:27276450-27337295 (+)
PWK/PhJ MGP_PWKPhJ_G0023968
 protein coding gene Chr19:25932959-25994750 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023772
 protein coding gene Chr19:26551665-26615284 (+)
WSB/EiJ MGP_WSBEiJ_G0024287
 protein coding gene Chr19:27321180-27385854 (+)



Homology
more
  • Human Ortholog
    JAK2, Janus kinase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JAK2, Janus kinase 2
  • Synonyms
    JTK10
  • Links
    NCBI Gene ID: 3717
    neXtProt AC: NX_O60674
    UniProt: O60674

  • Chr Location
    9p24.1; chr9:4984390-5129948 (+)  GRCh38
Human Diseases
more
  • Diseases
    4 with Jak2 mouse models; 20 with human JAK2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 2 models
IDs
 View 6 models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    7 with disease annotations
  • References
    7 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    104 phenotypes from 15 alleles in 18 genetic backgrounds
    39 phenotypes from multigenic genotypes
    138 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for null mutations die during midgestation due to a failure of erythropoieses. Mice expressing a conditional allele activated in mammary tissue exhibit lactation deficiency due to impaired alveologenesis. Mice homozygous for a knock-in allele exhibit myeloproliferative neoplasm.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    244
  • GO References
    60
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1028
  • Tissues
    83
  • cDNA Data
    89
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024789 Ensembl Gene Model | MGI Sequence Detail 61253 C57BL/6J ±  kb
    transcript ENSMUST00000065796 Ensembl | MGI Sequence Detail 5030 Not Applicable  
    polypeptide ENSMUSP00000064394 Ensembl | MGI Sequence Detail 1132 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      Genomic 2
      cDNA 89
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11517, MGI:2147569, MGI:2147795
    References
    more
    • Summaries
      All 379
      Developmental Gene Expression 20
      Diseases 7
      Gene Ontology 60
      Phenotypes 138
    • Earliest
      J:22689 Wilks AF, et al., The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. Gene. 1989 Dec 21;85(1):67-74
    • Latest
      J:354893 Fidler TP, et al., Suppression of IL-1beta promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis. Nat Cardiovasc Res. 2024 Jan;3(1):60-75
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory