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Junb Gene Detail
Summary
  • Symbol
    Junb
  • Name
    jun B proto-oncogene
  • Feature Type
    protein coding gene
  • IDs
    MGI:96647
    NCBI Gene: 16477
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:85703538-85705377 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 41.41 cM, cytoband C2-D1
  • Mapping Data
    30 experiments
Strain
Comparison
more
  • SNPs within 2kb
    96 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96647
 protein coding gene Chr8:85701113-85705377 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033884
 protein coding gene Chr8:85920944-85922784 (-)
A/J MGP_AJ_G0033867
 protein coding gene Chr8:82524615-82526455 (-)
AKR/J MGP_AKRJ_G0033793
 protein coding gene Chr8:84968380-84970220 (-)
BALB/cJ MGP_BALBcJ_G0033860
 protein coding gene Chr8:82656297-82658137 (-)
C3H/HeJ MGP_C3HHeJ_G0033570
 protein coding gene Chr8:85595253-85597092 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034380
 protein coding gene Chr8:89205616-89207455 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031321
 protein coding gene Chr8:76323582-76325420 (-)
CAST/EiJ MGP_CASTEiJ_G0032900
 protein coding gene Chr8:85026213-85028052 (-)
CBA/J MGP_CBAJ_G0033546
 protein coding gene Chr8:92223310-92225150 (-)
DBA/2J MGP_DBA2J_G0033699
 protein coding gene Chr8:82164441-82166281 (-)
FVB/NJ MGP_FVBNJ_G0033647
 protein coding gene Chr8:81118697-81120537 (-)
LP/J MGP_LPJ_G0033791
 protein coding gene Chr8:86021733-86023573 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033689
 protein coding gene Chr8:94799169-94801009 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034397
 protein coding gene Chr8:84958306-84960145 (-)
PWK/PhJ MGP_PWKPhJ_G0032604
 protein coding gene Chr8:81411425-81413263 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032440
 protein coding gene Chr8:83769928-83771767 (-)
WSB/EiJ MGP_WSBEiJ_G0033013
 protein coding gene Chr8:85392208-85394048 (-)



Homology
more
  • Human Ortholog
    JUNB, JunB proto-oncogene, AP-1 transcription factor subunit
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JUNB, JunB proto-oncogene, AP-1 transcription factor subunit
  • Synonyms
    AP-1
  • Links
    NCBI Gene ID: 3726
    neXtProt AC: NX_P17275
    UniProt: P17275

  • Chr Location
    19p13.13; chr19:12791486-12793315 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Junb mouse models; 2 with human JUNB associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    48 phenotypes from 2 alleles in 4 genetic backgrounds
    27 phenotypes from multigenic genotypes
    94 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die between embryonic day 8.5-10 due to impaired placental development. Embryos are severely growth retarded, but cell proliferation is normal, reflecting a failure to establish vascular interactions with the maternal circulation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    103
  • cDNA Data
    148
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16477 NCBI Gene Model | MGI Sequence Detail 1840 C57BL/6J ±  kb
    transcript NM_008416 RefSeq | MGI Sequence Detail 1840 ZRU/MplStud  
    polypeptide P09450 UniProt | EBI | MGI Sequence Detail 344 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 161
      Genomic 5
      cDNA 152
      Primer pair 3
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-11539
    References
    more
    • Summaries
      All 211
      Developmental Gene Expression 24
      Diseases 2
      Gene Ontology 18
      Phenotypes 94
    • Earliest
      J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory