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Jup Gene Detail
Summary
  • Symbol
    Jup
  • Name
    junction plakoglobin
  • Synonyms
    Ctnng, D930025P04Rik, gamma-catenin, PG, plakoglobin
  • Feature Type
    protein coding gene
  • IDs
    MGI:96650
    NCBI Gene: 16480
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:100259784-100288589 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 63.47 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    830 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96650
 protein coding gene Chr11:100259682-100288639 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019152
 protein coding gene Chr11:103127571-103156093 (-)
A/J MGP_AJ_G0019120
 protein coding gene Chr11:98815804-98845629 (-)
AKR/J MGP_AKRJ_G0019089
 protein coding gene Chr11:101859473-101888337 (-)
BALB/cJ MGP_BALBcJ_G0019094
 protein coding gene Chr11:99297411-99326017 (-)
C3H/HeJ MGP_C3HHeJ_G0018903
 protein coding gene Chr11:102059919-102089967 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019543
 protein coding gene Chr11:106324875-106359856 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017169
 protein coding gene Chr11:96232630-96262320 (-)
CAST/EiJ MGP_CASTEiJ_G0018457
 protein coding gene Chr11:103023920-103058986 (-)
CBA/J MGP_CBAJ_G0018872
 protein coding gene Chr11:110753465-110784810 (-)
DBA/2J MGP_DBA2J_G0018984
 protein coding gene Chr11:98355656-98384236 (-)
FVB/NJ MGP_FVBNJ_G0018974
 protein coding gene Chr11:97886216-97914971 (-)
LP/J MGP_LPJ_G0019053
 protein coding gene Chr11:103669682-103699071 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019005
 protein coding gene Chr11:110370954-110400490 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019581
 protein coding gene Chr11:102205625-102235307 (-)
PWK/PhJ MGP_PWKPhJ_G0018220
 protein coding gene Chr11:99391281-99420822 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018012
 protein coding gene Chr11:101923728-101952885 (-)
WSB/EiJ MGP_WSBEiJ_G0018506
 protein coding gene Chr11:102190471-102221540 (-)



Homology
more
  • Human Ortholog
    JUP, junction plakoglobin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    JUP, junction plakoglobin
  • Synonyms
    CTNNG, DP3, DPIII, PDGB, PG, PKGB
  • Links
    NCBI Gene ID: 3728
    neXtProt AC: NX_P14923
    UniProt: P14923

  • Chr Location
    17q21.2; chr17:41754604-41786931 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Jup mouse models; 7 with human JUP associations

Human Disease Mouse Models
      
IDs
 View 4 models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    5 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    94 phenotypes from 10 alleles in 11 genetic backgrounds
    11 phenotypes from multigenic genotypes
    4 images
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die with severe heart defects at embryonic day 10.5-16, depending on genetic background. Mutants that survive to birth exhibit skin blistering and subcorneal acantholysis associated with reduced number of desmosomes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    94
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1136
  • Tissues
    166
  • cDNA Data
    14
  • Literature Summary
    63
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000001552 Ensembl Gene Model | MGI Sequence Detail 28806 C57BL/6J ±  kb
    transcript ENSMUST00000107403 Ensembl | MGI Sequence Detail 2386 Not Applicable  
    polypeptide ENSMUSP00000103026 Ensembl | MGI Sequence Detail 745 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11544, MGI:2144342, MGI:2144558
    References
    more
    • Summaries
      All 173
      Developmental Gene Expression 63
      Diseases 4
      Gene Ontology 24
      Phenotypes 54
    • Earliest
      J:37381 Cowin P, et al., Plakoglobin: a protein common to different kinds of intercellular adhering junctions. Cell. 1986 Sep 26;46(7):1063-73
    • Latest
      J:350920 Hung M, et al., Cadherin-dependent adhesion is required for muscle stem cell niche anchorage and maintenance. Development. 2024 Apr 1;151(7):dev202387
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory