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Kcna5 Gene Detail
Summary
  • Symbol
    Kcna5
  • Name
    potassium voltage-gated channel, shaker-related subfamily, member 5
  • Synonyms
    Kv1.5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96662
    NCBI Gene: 16493
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:126509514-126512375 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 61.35 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96662
 protein coding gene Chr6:126509514-126512518 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031302
 protein coding gene Chr6:129979413-129982278 (-)
A/J MGP_AJ_G0031273
 protein coding gene Chr6:125036108-125038969 (-)
AKR/J MGP_AKRJ_G0031201
 protein coding gene Chr6:128425949-128428810 (-)
BALB/cJ MGP_BALBcJ_G0031280
 protein coding gene Chr6:124614755-124617616 (-)
C3H/HeJ MGP_C3HHeJ_G0031004
 protein coding gene Chr6:128552324-128555185 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031737
 protein coding gene Chr6:133364099-133366960 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028885
 protein coding gene Chr6:122227218-122230081 (-)
CAST/EiJ MGP_CASTEiJ_G0030385
 protein coding gene Chr6:128744964-128747835 (-)
CBA/J MGP_CBAJ_G0030965
 protein coding gene Chr6:138492727-138495588 (-)
DBA/2J MGP_DBA2J_G0031121
 protein coding gene Chr6:123942223-123945084 (-)
FVB/NJ MGP_FVBNJ_G0031070
 protein coding gene Chr6:122865391-122868252 (-)
LP/J MGP_LPJ_G0031201
 protein coding gene Chr6:130099163-130102024 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031109
 protein coding gene Chr6:142486543-142489502 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031772
 protein coding gene Chr6:128379637-128382502 (-)
PWK/PhJ MGP_PWKPhJ_G0030100
 protein coding gene Chr6:122194039-122196907 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029929
 protein coding gene Chr6:126450681-126453551 (-)
WSB/EiJ MGP_WSBEiJ_G0030470
 protein coding gene Chr6:128738041-128740903 (-)



Homology
more
  • Human Ortholog
    KCNA5, potassium voltage-gated channel subfamily A member 5
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNA5, potassium voltage-gated channel subfamily A member 5
  • Synonyms
    ATFB7, HCK1, HK2, HPCN1, KV1.5, PCN1
  • Links
    NCBI Gene ID: 3741
    neXtProt AC: NX_P22460
    UniProt: P22460

  • Chr Location
    12p13.32; chr12:5043879-5046788 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human KCNA5 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal microglial proliferation and nitric oxide release after LPS treatment or facial nerve lesion. Mice homozygous for a knock-in allele exhibit impaired hypoxic pulmonary vasoconstriction, and resistance to drug-induced cardiac QT prolongation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    107
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    943
  • Tissues
    45
  • cDNA Data
    12
  • Literature Summary
    14
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000045534 Ensembl Gene Model | MGI Sequence Detail 2862 C57BL/6J ±  kb
transcript ENSMUST00000060972 Ensembl | MGI Sequence Detail 2862 Not Applicable  
polypeptide ENSMUSP00000055673 Ensembl | MGI Sequence Detail 602 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    Genomic 6
    cDNA 14
    Primer pair 4
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-11566
References
more
  • Summaries
    All 69
    Developmental Gene Expression 14
    Gene Ontology 15
    Phenotypes 11
  • Earliest
    J:2710 Lesage F, et al., Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells. FEBS Lett. 1992 Sep 28;310(2):162-6
  • Latest
    J:354242 Wu Y, et al., Transcriptome analysis reveals EBF1 ablation-induced injuries in cardiac system. Theranostics. 2024;14(12):4894-4915
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory