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Kcna6 Gene Detail
Summary
  • Symbol
    Kcna6
  • Name
    potassium voltage-gated channel, shaker-related, subfamily, member 6
  • Synonyms
    Kv1.6, MK1.6
  • Feature Type
    protein coding gene
  • IDs
    MGI:96663
    NCBI Gene: 16494
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:126685292-126717610 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 61.72 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1013 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96663
 protein coding gene Chr6:126685292-126717637 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031304
 protein coding gene Chr6:130165214-130197164 (-)
A/J MGP_AJ_G0031275
 protein coding gene Chr6:125214079-125246741 (-)
AKR/J MGP_AKRJ_G0031203
 protein coding gene Chr6:128605692-128639353 (-)
BALB/cJ MGP_BALBcJ_G0031282
 protein coding gene Chr6:124790918-124824526 (-)
C3H/HeJ MGP_C3HHeJ_G0031006
 protein coding gene Chr6:128730801-128762760 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031739
 protein coding gene Chr6:133555726-133590944 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028887
 protein coding gene Chr6:122410373-122443281 (-)
CAST/EiJ MGP_CASTEiJ_G0030387
 protein coding gene Chr6:128932151-128965661 (-)
CBA/J MGP_CBAJ_G0030967
 protein coding gene Chr6:138691576-138728641 (-)
DBA/2J MGP_DBA2J_G0031123
 protein coding gene Chr6:124118946-124151250 (-)
FVB/NJ MGP_FVBNJ_G0031072
 protein coding gene Chr6:123044258-123078896 (-)
LP/J MGP_LPJ_G0031203
 protein coding gene Chr6:130279891-130314975 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031111
 protein coding gene Chr6:142674912-142709474 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031774
 protein coding gene Chr6:128562065-128595685 (-)
PWK/PhJ MGP_PWKPhJ_G0030102
 protein coding gene Chr6:122374500-122408742 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029931
 protein coding gene Chr6:126635880-126668256 (-)
WSB/EiJ MGP_WSBEiJ_G0030472
 protein coding gene Chr6:128923459-128957785 (-)



Homology
more
  • Human Ortholog
    KCNA6, potassium voltage-gated channel subfamily A member 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNA6, potassium voltage-gated channel subfamily A member 6
  • Synonyms
    HBK2, KV1.6, PPP1R96
  • Links
    NCBI Gene ID: 3742
    neXtProt AC: NX_P17658
    UniProt: P17658

  • Chr Location
    12p13.32; chr12:4809334-4851112 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in an increased thermal nociceptive threshold and in females an increase in circulating triglyceride levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    930
  • Tissues
    31
  • cDNA Data
    5
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16494 NCBI Gene Model | MGI Sequence Detail 32319 C57BL/6J ±  kb
    transcript NM_001410072 RefSeq | MGI Sequence Detail 5924 ZRU/MplStud  
    polypeptide Q61923 UniProt | EBI | MGI Sequence Detail 529 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000000813 voltage-gated potassium channel subunit KCNA6
      (term hierarchy)
    • InterPro Domains
      IPR000210 BTB/POZ domain
      IPR005821 Ion transport domain
      IPR003131 Potassium channel tetramerisation-type BTB domain
      IPR003968 Potassium channel, voltage dependent, Kv
      IPR003972 Potassium channel, voltage dependent, Kv1
      IPR004053 Potassium voltage-gated channel subfamily A member 6
      IPR046988 Potassium voltage-gated channel subfamily A member 6, BTB/POZ domain
      IPR011333 SKP1/BTB/POZ domain superfamily
      IPR027359 Voltage-dependent channel domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 5
      cDNA 7
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11567
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 7
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:2710 Lesage F, et al., Developmental expression of voltage-sensitive K+ channels in mouse skeletal muscle and C2C12 cells. FEBS Lett. 1992 Sep 28;310(2):162-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory