Kin MGI Mouse Gene Detail - MGI:96676 - Kin17 DNA and RNA binding protein

Symbol

Kin
Name

Kin17 DNA and RNA binding protein
Synonyms

antigenic determinant of rec-A protein, Kin17

Feature Type

protein coding gene
IDs

MGI:96676
NCBI Gene: 16588
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:10085397-10097512 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 6.88 cM, cytoband A1-A3
Mapping Data

2 experiments

SNPs within 2kb

541 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96676	protein coding gene	Chr2:10085397-10097617 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025338	protein coding gene	Chr2:7433234-7445447 (+)
A/J	MGP_AJ_G0025315	protein coding gene	Chr2:7099406-7111776 (+)
AKR/J	MGP_AKRJ_G0025284	protein coding gene	Chr2:7333421-7345634 (+)
BALB/cJ	MGP_BALBcJ_G0025311	protein coding gene	Chr2:7102316-7114529 (+)
C3H/HeJ	MGP_C3HHeJ_G0025071	protein coding gene	Chr2:7278908-7291121 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025753	protein coding gene	Chr2:7623613-7635826 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023167	protein coding gene	Chr2:6612757-6625137 (+)
CAST/EiJ	MGP_CASTEiJ_G0024534	protein coding gene	Chr2:7307535-7318616 (+)
CBA/J	MGP_CBAJ_G0025050	protein coding gene	Chr2:7937014-7949227 (+)
DBA/2J	MGP_DBA2J_G0025182	protein coding gene	Chr2:7032224-7044437 (+)
FVB/NJ	MGP_FVBNJ_G0025144	protein coding gene	Chr2:6972979-6985633 (+)
LP/J	MGP_LPJ_G0025268	protein coding gene	Chr2:7310399-7322612 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025176	protein coding gene	Chr2:7915856-7928096 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025811	protein coding gene	Chr2:7278255-7290468 (+)
PWK/PhJ	MGP_PWKPhJ_G0024285	protein coding gene	Chr2:7013658-7027932 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024085	protein coding gene	Chr2:7267069-7278845 (+)
WSB/EiJ	MGP_WSBEiJ_G0024604	protein coding gene	Chr2:7372750-7387980 (+)

Human Ortholog

KIN, Kin17 DNA and RNA binding protein

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIN, Kin17 DNA and RNA binding protein
Synonyms

BTCD, KIN17, Rts2
Links

HGNC:6327

NCBI Gene ID: 22944

neXtProt AC: NX_O60870

UniProt: O60870
Chr Location

10p14; chr10:7750962-7787993 (-) GRCh38

MGI Vertebrate Homology

Kin stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KIN
Gene Tree

Kin

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
6 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Endonuclease-mediated

1
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

23
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

21
cDNA Data

42
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase kin

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All Sequences

40
RefSeq

7
UniProt

1
CCDS

CCDS15676.1

Ensembl

ENSMUSG00000037262 (Evidence)
NCBI Gene

16588

			Length	Strain/Species	Flank
genomic	16588	NCBI Gene Model \| MGI Sequence Detail	12116	C57BL/6J	± kb
transcript	NM_001420344	RefSeq \| MGI Sequence Detail	1518	C57BL/6
polypeptide	Q8K339	UniProt \| EBI \| MGI Sequence Detail	391	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009326 DNA/RNA-binding protein KIN17

(term hierarchy)
InterPro Domains

IPR019447 DNA/RNA-binding protein Kin17, WH-like domain

IPR038254 DNA/RNA-binding protein KIN17, WH-like domain superfamily

IPR041995 Kin17, KOW domain

IPR037321 KIN17-like protein

IPR041330 KN17, SH3-like C-terminal domain

IPR014722 Large ribosomal subunit protein uL2, domain 2

IPR036236 Zinc finger C2H2 superfamily

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All nucleic 44

Genomic 2

cDNA 42

Microarray probesets 3

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MGD-MRK-11587

Summaries

All 45

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 6
Earliest

J:15676 Witkin EM, Ultraviolet mutagenesis and inducible DNA repair in Escherichia coli. Bacteriol Rev. 1976 Dec;40(4):869-907
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Kin:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr16075	Chr2:10084993-10084997 (+)	-402 bp
Tssr16076	Chr2:10085386-10085406 (+)	-1 bp
Tssr16077	Chr2:10085411-10085429 (+)	23 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24