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Kras Gene Detail
Summary
  • Symbol
    Kras
  • Name
    Kirsten rat sarcoma viral oncogene homolog
  • Synonyms
    Ki-ras, K-ras, Kras-2, Kras2
  • Feature Type
    protein coding gene
  • IDs
    MGI:96680
    NCBI Gene: 16653
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr6:145162425-145195965 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 77.37 cM, cytoband G2
  • Mapping Data
    78 experiments
Strain
Comparison
more
  • SNPs within 2kb
    248 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    13
  • RFLP
    17
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96680
 protein coding gene Chr6:145162425-145197631 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031479
 protein coding gene Chr6:150200815-150234355 (-)
A/J MGP_AJ_G0031454
 protein coding gene Chr6:144255543-144289120 (-)
AKR/J MGP_AKRJ_G0031382
 protein coding gene Chr6:148552327-148588897 (-)
BALB/cJ MGP_BALBcJ_G0031461
 protein coding gene Chr6:144011812-144045679 (-)
C3H/HeJ MGP_C3HHeJ_G0031183
 protein coding gene Chr6:148586022-148620929 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031923
 protein coding gene Chr6:154252306-154292275 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029047
 protein coding gene Chr6:143007831-143041361 (-)
CAST/EiJ MGP_CASTEiJ_G0030551
 protein coding gene Chr6:148208644-148246097 (-)
CBA/J MGP_CBAJ_G0031143
 protein coding gene Chr6:160111128-160148907 (-)
DBA/2J MGP_DBA2J_G0031300
 protein coding gene Chr6:143059915-143093394 (-)
FVB/NJ MGP_FVBNJ_G0031251
 protein coding gene Chr6:141790626-141824838 (-)
LP/J MGP_LPJ_G0031384
 protein coding gene Chr6:150302729-150339974 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031291
 protein coding gene Chr6:163899977-163935853 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031955
 protein coding gene Chr6:148385446-148419959 (-)
PWK/PhJ MGP_PWKPhJ_G0030278
 protein coding gene Chr6:141564021-141598256 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030102
 protein coding gene Chr6:146541686-146576792 (-)
WSB/EiJ MGP_WSBEiJ_G0030644
 protein coding gene Chr6:148983430-149016977 (-)



Homology
more
  • Human Ortholog
    KRAS, KRAS proto-oncogene, GTPase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRAS, KRAS proto-oncogene, GTPase
  • Synonyms
    CFC2, c-Ki-ras, c-Ki-ras2, 'C-K-RAS, C-K-RAS, KI-RAS, K-Ras, KRAS1, K-Ras 2, KRAS2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, NS, NS3, OES, RALD, RASK2
  • Links
    NCBI Gene ID: 3845
    neXtProt AC: NX_P01116
    UniProt: P01116

  • Chr Location
    12p12.1; chr12:25205246-25250936 (-)  GRCh38
Human Diseases
more
  • Diseases
    8 with Kras mouse models; 28 with human KRAS associations

Human Disease Mouse Models
      
IDs
 View 2 models
IDs
 View 4 models
IDs
 View 19 models
IDs
 View 1 model
      
IDs
 View 1 model
IDs
 View 3 models
IDs
 View 13 models
IDs
 View 4 models
      
IDs
IDs
 View 1 "NOT" model
IDs
IDs
 View 1 model
IDs
IDs
IDs
 View 3 models
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    10 with disease annotations
  • References
    57 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    211 phenotypes from 15 alleles in 52 genetic backgrounds
    264 phenotypes from multigenic genotypes
    7 images
    1786 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality, decreased fetal growth, pericardial edema, anemia, and liver hypoplasia. Mice heterozygous for various knock-in alleles exhibit increased tumorigenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    59
  • GO References
    26
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1208
  • Tissues
    141
  • cDNA Data
    16
  • Literature Summary
    24
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030265 Ensembl Gene Model | MGI Sequence Detail 33541 C57BL/6J ±  kb
    transcript ENSMUST00000111710 Ensembl | MGI Sequence Detail 1194 Not Applicable  
    polypeptide ENSMUSP00000107339 Ensembl | MGI Sequence Detail 189 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      Genomic 10
      cDNA 19
      Primer pair 17
      Other 6

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-11597, MGD-MRK-11601, MGI:2141518
    References
    more
    • Summaries
      All 2070
      Developmental Gene Expression 24
      Diseases 57
      Gene Ontology 26
      Phenotypes 1786
    • Earliest
      J:6226 Scolnick EM, et al., Guanine nucleotide-binding activity as an assay for src protein of rat-derived murine sarcoma viruses. Proc Natl Acad Sci U S A. 1979 Oct;76(10):5355-9
    • Latest
      J:358843 Xue Y, et al., TET2-STAT3-CXCL5 nexus promotes neutrophil lipid transfer to fuel lung adeno-to-squamous transition. J Exp Med. 2024 Jul 1;221(7)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory