Krt9 MGI Mouse Gene Detail - MGI:96696

Symbol

Krt9
Name

keratin 9
Synonyms

K9, Krt1-9

Feature Type

protein coding gene
IDs

MGI:96696
NCBI Gene: 107656
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr11:100077607-100084072 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 63.43 cM
Mapping Data

1 experiment

SNPs within 2kb

289 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96696	protein coding gene	Chr11:100077607-100084072 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019144	protein coding gene	Chr11:102937319-102945199 (-)
A/J	MGP_AJ_G0019112	protein coding gene	Chr11:98594609-98600792 (-)
AKR/J	MGP_AKRJ_G0019081	protein coding gene	Chr11:101636901-101643204 (-)
BALB/cJ	MGP_BALBcJ_G0019086	protein coding gene	Chr11:99108327-99115243 (-)
C3H/HeJ	MGP_C3HHeJ_G0018895	protein coding gene	Chr11:101841830-101849486 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0019535	protein coding gene	Chr11:106104764-106112645 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017162	protein coding gene	Chr11:96046613-96052895 (-)
CAST/EiJ	MGP_CASTEiJ_G0018449	protein coding gene	Chr11:102823543-102830127 (-)
CBA/J	MGP_CBAJ_G0018864	protein coding gene	Chr11:110539187-110545538 (-)
DBA/2J	MGP_DBA2J_G0018977	protein coding gene	Chr11:98167943-98174318 (-)
FVB/NJ	MGP_FVBNJ_G0018966	protein coding gene	Chr11:97670383-97676702 (-)
LP/J	MGP_LPJ_G0019045	protein coding gene	Chr11:103477133-103485463 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018997	protein coding gene	Chr11:110162301-110168466 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019573	protein coding gene	Chr11:102014134-102020461 (-)
PWK/PhJ	MGP_PWKPhJ_G0018212	protein coding gene	Chr11:99195626-99202141 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018004	protein coding gene	Chr11:101722674-101729316 (-)
WSB/EiJ	MGP_WSBEiJ_G0018498	protein coding gene	Chr11:101982323-101988669 (-)

Human Ortholog

KRT9, keratin 9

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KRT9, keratin 9
Synonyms

CK-9, EPPK, EPPK1, K9
Links

HGNC:6447

NCBI Gene ID: 3857

neXtProt AC: NX_P35527

UniProt: P35527
Chr Location

17q21.2; chr17:41565836-41572059 (-) GRCh38

MGI Vertebrate Homology

Krt9 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KRT9
Gene Tree

Krt9

Diseases

1 with human KRT9 associations

				Human Disease	Mouse Models
				epidermolytic palmoplantar keratoderma 1 IDs epidermolytic palmoplantar keratoderma 1 DOID:0070552 OMIM:144200

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

17 phenotypes from 2 alleles in 2 genetic backgrounds
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Genomic Mutations

2 involving Krt9
Incidental Mutations

APF
Find Mice (IMSR)

50 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit hyperpigmented calluses on the footpad with acanthosis, hyperkeratosis, thick epidermis and increased keratinocyte proliferation.

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All GO Annotations

14
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

727
Tissues

13
cDNA Data

3
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

26
RefSeq

2
UniProt

1
CCDS

CCDS25412.1

Ensembl

ENSMUSG00000051617 (Evidence)
NCBI Gene

107656

			Length	Strain/Species	Flank
genomic	107656	NCBI Gene Model \| MGI Sequence Detail	6466	C57BL/6J	± kb
transcript	NM_201255	RefSeq \| MGI Sequence Detail	2580	Not Specified
polypeptide	Q6RHW0	UniProt \| EBI \| MGI Sequence Detail	743	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009503 keratin, type I cytoskeletal 9

(term hierarchy)
InterPro Domains

IPR039008 Intermediate filament, rod domain

IPR002957 Keratin, type I

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All nucleic 3

cDNA 3

Microarray probesets 1

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MGD-MRK-11651

Summaries

All 44

Developmental Gene Expression 8

Gene Ontology 7

Phenotypes 15
Earliest

J:51113 Powell BC, et al., The role of keratin proteins and their genes in the growth, structure and properties of hair. EXS. 1997;78:59-148
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Krt9:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr110761	Chr11:100084079-100084082 (-)	-9 bp
Tssr110760	Chr11:100083925-100083929 (-)	145 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24