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Krt2 Gene Detail
Summary
  • Symbol
    Krt2
  • Name
    keratin 2
  • Synonyms
    Krt2-17, Krt2-2, Krt2e
  • Feature Type
    protein coding gene
  • IDs
    MGI:96699
    NCBI Gene: 16681
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:101719124-101726604 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 57.03 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96699
 protein coding gene Chr15:101719124-101727391 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022388
 protein coding gene Chr15:103946361-103953668 (-)
A/J MGP_AJ_G0022351
 protein coding gene Chr15:99839795-99847094 (-)
AKR/J MGP_AKRJ_G0022326
 protein coding gene Chr15:102873933-102885081 (-)
BALB/cJ MGP_BALBcJ_G0022354
 protein coding gene Chr15:99910646-99917939 (-)
C3H/HeJ MGP_C3HHeJ_G0022121
 protein coding gene Chr15:102949993-102957294 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022803
 protein coding gene Chr15:107807374-107814823 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020326
 protein coding gene Chr15:95646755-95654036 (-)
CAST/EiJ MGP_CASTEiJ_G0021647
 protein coding gene Chr15:103795198-103802650 (-)
CBA/J MGP_CBAJ_G0022090
 protein coding gene Chr15:111562743-111570040 (-)
DBA/2J MGP_DBA2J_G0022221
 protein coding gene Chr15:99151059-99158511 (-)
FVB/NJ MGP_FVBNJ_G0022197
 protein coding gene Chr15:98208201-98215892 (-)
LP/J MGP_LPJ_G0022290
 protein coding gene Chr15:104094329-104101634 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022219
 protein coding gene Chr15:115184915-115192365 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022815
 protein coding gene Chr15:102908277-102915713 (-)
PWK/PhJ MGP_PWKPhJ_G0021387
 protein coding gene Chr15:99294657-99302263 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021219
 protein coding gene Chr15:102738896-102746263 (-)
WSB/EiJ MGP_WSBEiJ_G0021697
 protein coding gene Chr15:103531206-103538500 (-)



Homology
more
  • Human Ortholog
    KRT2, keratin 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KRT2, keratin 2
  • Synonyms
    CK-2e, K2e, KRT2A, KRT2E, KRTE
  • Links
    NCBI Gene ID: 3849
    neXtProt AC: NX_P35908
    UniProt: P35908

  • Chr Location
    12q13.13; chr12:52644558-52652211 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Krt2 mouse models; 2 with human KRT2 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 5 genetic backgrounds
    5 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
ENU-induced mutant mice exhibit scaly skin and increased pigmentation in the tail, ears and feet. Mice homozygous for a knock-out allele show scaly skin, acanthosis, hyperkeratosis, increased water loss, ear skin inflammation, and aberrant aggregation of keratin 10 in suprabasal epidermal keratinocytes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    839
  • Tissues
    29
  • cDNA Data
    9
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064201 Ensembl Gene Model | MGI Sequence Detail 7481 C57BL/6J ±  kb
    transcript ENSMUST00000023712 Ensembl | MGI Sequence Detail 2613 Not Applicable  
    polypeptide ENSMUSP00000023712 Ensembl | MGI Sequence Detail 707 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 16
      Genomic 6
      cDNA 9
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11654, MGI:2146252
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 6
      Phenotypes 39
    • Earliest
      J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory