Krt4 MGI Mouse Gene Detail - MGI:96701

Symbol

Krt4
Name

keratin 4
Synonyms

K4, Krt-2.4, Krt2-4

Feature Type

protein coding gene
IDs

MGI:96701
NCBI Gene: 16682
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr15:101826970-101833170 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 57.13 cM
Mapping Data

3 experiments

SNPs within 2kb

248 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96701	protein coding gene	Chr15:101826970-101833170 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022392	protein coding gene	Chr15:104051670-104057896 (-)
A/J	MGP_AJ_G0022355	protein coding gene	Chr15:99956404-99962603 (-)
AKR/J	MGP_AKRJ_G0022330	protein coding gene	Chr15:102992191-102998390 (-)
BALB/cJ	MGP_BALBcJ_G0022358	protein coding gene	Chr15:100018799-100025025 (-)
C3H/HeJ	MGP_C3HHeJ_G0022125	protein coding gene	Chr15:103060125-103066324 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022807	protein coding gene	Chr15:107921354-107927553 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020330	protein coding gene	Chr15:95753800-95760089 (-)
CAST/EiJ	MGP_CASTEiJ_G0021651	protein coding gene	Chr15:103916531-103922728 (-)
CBA/J	MGP_CBAJ_G0022094	protein coding gene	Chr15:111676498-111682697 (-)
DBA/2J	MGP_DBA2J_G0022225	protein coding gene	Chr15:99258066-99264265 (-)
FVB/NJ	MGP_FVBNJ_G0022201	protein coding gene	Chr15:98316129-98322328 (-)
LP/J	MGP_LPJ_G0022294	protein coding gene	Chr15:104206430-104212656 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022223	protein coding gene	Chr15:115299191-115305390 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022819	protein coding gene	Chr15:103017667-103023889 (-)
PWK/PhJ	MGP_PWKPhJ_G0021391	protein coding gene	Chr15:99405400-99411599 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021223	protein coding gene	Chr15:102849929-102856173 (-)
WSB/EiJ	MGP_WSBEiJ_G0021701	protein coding gene	Chr15:103640218-103646416 (-)

Human Ortholog

KRT4, keratin 4

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KRT4, keratin 4
Synonyms

CK-4, CK4, CYK4, K4, WSN1
Links

HGNC:6441

NCBI Gene ID: 3851

neXtProt AC: NX_P19013

UniProt: P19013
Chr Location

12q13.13; chr12:52806549-52814116 (-) GRCh38

MGI Vertebrate Homology

Krt4 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: KRT4
Gene Tree

Krt4

Diseases

1 with Krt4 mouse models; 1 with human KRT4 associations

Human Disease

Mouse Models

white sponge nevus

IDs

View 2 models

white sponge nevus 1

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

15 phenotypes from 2 alleles in 2 genetic backgrounds
2 images
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (ENU)

1
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

2
Targeted

3
Genomic Mutations

4 involving Krt4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

19 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for disruptions in this gene display hyperplasia throughout the epithelium of the esophagus and tongue. Mice homozygous or heterozygous for a dominant mutation display oral leukoplakia and homozygotes display postnatal growth retardation.

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All GO Annotations

13
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

876
Tissues

60
cDNA Data

24
Literature Summary

20

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KRT4

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All Sequences

32
RefSeq

2
UniProt

1
CCDS

CCDS37222.1

Ensembl

ENSMUSG00000059668 (Evidence)
NCBI Gene

16682

			Length	Strain/Species	Flank
genomic	16682	NCBI Gene Model \| MGI Sequence Detail	6201	C57BL/6J	± kb
transcript	NM_008475	RefSeq \| MGI Sequence Detail	2147	ZRU/MplStud
polypeptide	P07744	UniProt \| EBI \| MGI Sequence Detail	525	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009479 keratin, type II cytoskeletal 4

(term hierarchy)
InterPro Domains

IPR018039 Intermediate filament protein, conserved site

IPR039008 Intermediate filament, rod domain

IPR003054 Keratin, type II

IPR032444 Keratin type II head
GlyGen

P07744 1 site, 1 O-linked glycan (1 site)

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All nucleic 31

Genomic 4

cDNA 26

Primer pair 1

Microarray probesets 4

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MGD-MRK-11636, MGD-MRK-11656, MGD-MRK-38408, MGI:109363, MGI:2146191

Summaries

All 80

Developmental Gene Expression 20

Diseases 2

Gene Ontology 4

Phenotypes 30
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:328556 Sunny SS, et al., Multiple roles of Pax6 in postnatal cornea development. Dev Biol. 2022 Aug 29;491:1-12

TSS for Krt4:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136640	Chr15:101833160-101833177 (-)	1 bp
Tssr136639	Chr15:101827235-101827254 (-)	5,925 bp
Tssr136638	Chr15:101827014-101827025 (-)	6,150 bp
Tssr136637	Chr15:101827003-101827013 (-)	6,162 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24