Lalba MGI Mouse Gene Detail - MGI:96742

Symbol

Lalba
Name

lactalbumin, alpha
Synonyms

lactalbumin alpha

Feature Type

protein coding gene
IDs

MGI:96742
NCBI Gene: 16770
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr15:98378281-98380602 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 54.48 cM
Mapping Data

1 experiment

SNPs within 2kb

184 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96742	protein coding gene	Chr15:98378281-98380827 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022298	protein coding gene	Chr15:100205713-100207983 (-)
A/J	MGP_AJ_G0022257	protein coding gene	Chr15:96257191-96259477 (-)
AKR/J	MGP_AKRJ_G0022231	protein coding gene	Chr15:99192197-99194477 (-)
BALB/cJ	MGP_BALBcJ_G0022263	protein coding gene	Chr15:96452969-96455262 (-)
C3H/HeJ	MGP_C3HHeJ_G0022032	protein coding gene	Chr15:99251002-99253353 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022708	protein coding gene	Chr15:103910642-103912999 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020233	protein coding gene	Chr15:92171937-92174806 (-)
CAST/EiJ	MGP_CASTEiJ_G0021554	protein coding gene	Chr15:100111972-100114252 (-)
CBA/J	MGP_CBAJ_G0022000	protein coding gene	Chr15:107427637-107429937 (-)
DBA/2J	MGP_DBA2J_G0022126	protein coding gene	Chr15:95703754-95706208 (-)
FVB/NJ	MGP_FVBNJ_G0022106	protein coding gene	Chr15:94675842-94678128 (-)
LP/J	MGP_LPJ_G0022198	protein coding gene	Chr15:100350816-100353147 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022126	protein coding gene	Chr15:111465197-111467477 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022723	protein coding gene	Chr15:99294627-99298762 (-)
PWK/PhJ	MGP_PWKPhJ_G0021296	protein coding gene	Chr15:95821838-95824129 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021130	protein coding gene	Chr15:99117831-99126733 (-)
WSB/EiJ	MGP_WSBEiJ_G0021604	protein coding gene	Chr15:99828899-99831216 (-)

Human Ortholog

LALBA, lactalbumin alpha

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LALBA, lactalbumin alpha
Synonyms

HAMLET, LYZG
Links

HGNC:6480

NCBI Gene ID: 3906

neXtProt AC: NX_P00709

UniProt: P00709
Chr Location

12q13.11; chr12:48567684-48571845 (-) GRCh38

MGI Vertebrate Homology

Lalba stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: LALBA
Gene Tree

Lalba

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Lalba
Incidental Mutations

APF
Find Mice (IMSR)

8 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null females are unable to nurse their offspring and have increased milk viscosity.

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All GO Annotations

11
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

899
Tissues

145
cDNA Data

163
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

35
RefSeq

4
UniProt

2
CCDS

CCDS27795.1

Ensembl

ENSMUSG00000022991 (Evidence)
NCBI Gene

16770

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022991	Ensembl Gene Model \| MGI Sequence Detail	2322	C57BL/6J	± kb
transcript	ENSMUST00000023726	Ensembl \| MGI Sequence Detail	771	Not Applicable
polypeptide	ENSMUSP00000023726	Ensembl \| MGI Sequence Detail	143	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009649 alpha-lactalbumin

(term hierarchy)
PDB

1NF5, 1NHE, 1NKH, 1NMM, 1NQI, 1NWG, 1O23, 1OQM, 1PZY, 1YRO, 2FYC, 2FYD
InterPro Domains

IPR001916 Glycoside hydrolase, family 22

IPR019799 Glycoside hydrolase family 22 domain

IPR000545 Lactalbumin

IPR023346 Lysozyme-like domain superfamily
GlyGen

P29752 1 site

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All nucleic 170

Genomic 4

cDNA 163

Primer pair 1

Other 2

Microarray probesets 3

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MGD-MRK-11732, MGI:2146204

Summaries

All 58

Developmental Gene Expression 5

Diseases 1

Gene Ontology 10

Phenotypes 24
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:285676 Suzuki A, et al., Genes and microRNAs associated with mouse cleft palate: A systematic review and bioinformatics analysis. Mech Dev. 2018 Apr;150:21-27

TSS for Lalba:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr136239	Chr15:98380658-98380665 (-)	-60 bp
Tssr136238	Chr15:98380612-98380623 (-)	-16 bp
Tssr136237	Chr15:98380567-98380586 (-)	25 bp
Tssr136236	Chr15:98380088-98380112 (-)	502 bp
Tssr136235	Chr15:98380064-98380074 (-)	533 bp
Tssr136234	Chr15:98379848-98379851 (-)	752 bp
Tssr136233	Chr15:98378544-98378561 (-)	2,049 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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