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Lamb1 Gene Detail
Summary
  • Symbol
    Lamb1
  • Name
    laminin B1
  • Synonyms
    C80098, C81607, D130003D08Rik, Lamb-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96743
    NCBI Gene: 16777
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:31315233-31379643 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 13.39 cM
  • Mapping Data
    25 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2078 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96743
 protein coding gene Chr12:31315230-31379643 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019658
 protein coding gene Chr12:29200547-29264877 (+)
A/J MGP_AJ_G0019625
 protein coding gene Chr12:28382380-28446694 (+)
AKR/J MGP_AKRJ_G0019596
 protein coding gene Chr12:29294568-29358924 (+)
BALB/cJ MGP_BALBcJ_G0019602
 protein coding gene Chr12:28606903-28671546 (+)
C3H/HeJ MGP_C3HHeJ_G0019406
 protein coding gene Chr12:29154089-29218412 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020049
 protein coding gene Chr12:30106032-30170250 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017674
 protein coding gene Chr12:27676065-27742108 (+)
CAST/EiJ MGP_CASTEiJ_G0018961
 protein coding gene Chr12:24149854-24218075 (+)
CBA/J MGP_CBAJ_G0019377
 protein coding gene Chr12:31072653-31138603 (+)
DBA/2J MGP_DBA2J_G0019491
 protein coding gene Chr12:28213454-28278177 (+)
FVB/NJ MGP_FVBNJ_G0019482
 protein coding gene Chr12:28008240-28072660 (+)
LP/J MGP_LPJ_G0019561
 protein coding gene Chr12:29300891-29365155 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019517
 protein coding gene Chr12:30731451-30799464 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020089
 protein coding gene Chr12:28806091-28873921 (+)
PWK/PhJ MGP_PWKPhJ_G0018728
 protein coding gene Chr12:22939811-23004621 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018516
 protein coding gene Chr12:23409694-23476134 (+)
WSB/EiJ MGP_WSBEiJ_G0019011
 protein coding gene Chr12:29047901-29114085 (+)



Homology
more
  • Human Ortholog
    LAMB1, laminin subunit beta 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAMB1, laminin subunit beta 1
  • Synonyms
    CLM, LIS5
  • Links
    NCBI Gene ID: 3912
    neXtProt AC: NX_P07942
    UniProt: P07942

  • Chr Location
    7q31.1; chr7:107923799-108003213 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human LAMB1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Embryos homozygous for a gene trapped allele lack basement membranes and fail to survive past E5.5. Mice heterozygous for a spontaneous mutation exhibit dystonis with impaired neuron firing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    61
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1295
  • Tissues
    293
  • cDNA Data
    27
  • Literature Summary
    110
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000002900 Ensembl Gene Model | MGI Sequence Detail 64411 C57BL/6J ±  kb
    transcript ENSMUST00000239496 Ensembl | MGI Sequence Detail 5778 Not Applicable  
    polypeptide ENSMUSP00000159366 Ensembl | MGI Sequence Detail 1834 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 47
      Genomic 1
      cDNA 30
      Primer pair 9
      Other 7

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11734, MGD-MRK-11737, MGI:2145087, MGI:2145103, MGI:2145114
    References
    more
    • Summaries
      All 228
      Developmental Gene Expression 110
      Gene Ontology 35
      Phenotypes 17
    • Earliest
      J:24442 Kurkinen M, et al., In vitro synthesis of laminin and entactin polypeptides. J Biol Chem. 1983 May 25;258(10):6543-8
    • Latest
      J:354189 Miao L, et al., beta1 integrins regulate cellular behaviour and cardiomyocyte organization during ventricular wall formation. Cardiovasc Res. 2024 Sep 21;120(11):1279-1294
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory