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Lcat Gene Detail
Summary
  • Symbol
    Lcat
  • Name
    lecithin cholesterol acyltransferase
  • Synonyms
    D8Wsu61e
  • Feature Type
    protein coding gene
  • IDs
    MGI:96755
    NCBI Gene: 16816
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:106666183-106670014 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.06 cM
  • Mapping Data
    18 experiments
Strain
Comparison
more
  • SNPs within 2kb
    188 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96755
 protein coding gene Chr8:106666183-106670034 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034069
 protein coding gene Chr8:108264710-108268569 (-)
A/J MGP_AJ_G0034050
 protein coding gene Chr8:103937585-103941460 (-)
AKR/J MGP_AKRJ_G0033976
 protein coding gene Chr8:106937316-106941147 (-)
BALB/cJ MGP_BALBcJ_G0034043
 protein coding gene Chr8:104120121-104124505 (-)
C3H/HeJ MGP_C3HHeJ_G0033755
 protein coding gene Chr8:107680120-107683951 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034563
 protein coding gene Chr8:112236330-112240161 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031505
 protein coding gene Chr8:97071003-97074652 (-)
CAST/EiJ MGP_CASTEiJ_G0033081
 protein coding gene Chr8:107199608-107205158 (-)
CBA/J MGP_CBAJ_G0033728
 protein coding gene Chr8:115841906-115845737 (-)
DBA/2J MGP_DBA2J_G0033883
 protein coding gene Chr8:103280828-103284659 (-)
FVB/NJ MGP_FVBNJ_G0033828
 protein coding gene Chr8:102214610-102218441 (-)
LP/J MGP_LPJ_G0033974
 protein coding gene Chr8:108479381-108483212 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033872
 protein coding gene Chr8:119032936-119036574 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034581
 protein coding gene Chr8:106905186-106909025 (-)
PWK/PhJ MGP_PWKPhJ_G0032782
 protein coding gene Chr8:102684837-102688820 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032623
 protein coding gene Chr8:105597454-105601326 (-)
WSB/EiJ MGP_WSBEiJ_G0033197
 protein coding gene Chr8:107591798-107595627 (-)



Homology
more
  • Human Ortholog
    LCAT, lecithin-cholesterol acyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LCAT, lecithin-cholesterol acyltransferase
  • Links
    NCBI Gene ID: 3931
    neXtProt AC: NX_P04180
    UniProt: P04180

  • Chr Location
    16q22.1; chr16:67939750-67944131 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Lcat mouse models; 2 with human LCAT associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 6 genetic backgrounds
    25 phenotypes from multigenic genotypes
    3 images
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes display severe hypoalphalipoproteinemia, variable hypertriglyceridemia, and accumulation of heterogeneous pre-beta HDL, as well as an attenuated increase in apoB-containing lipoproteins in response to dietary cholesterol.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    862
  • Tissues
    111
  • cDNA Data
    88
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000035237 Ensembl Gene Model | MGI Sequence Detail 3832 C57BL/6J ±  kb
    transcript ENSMUST00000038896 Ensembl | MGI Sequence Detail 1342 Not Applicable  
    polypeptide ENSMUSP00000038232 Ensembl | MGI Sequence Detail 438 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 98
      Genomic 3
      cDNA 89
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11757, MGD-MRK-34112, MGI:106418, MGI:2142459
    References
    more
    • Summaries
      All 99
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 11
      Phenotypes 38
    • Earliest
      J:10041 Scherer G, et al., Gene mapping on mouse chromosome 8 by interspecific crosses: new data on a linkage group conserved on human chromosome 16q. Genomics. 1989 Aug;5(2):275-82
    • Latest
      J:305409 Tsujita M, et al., Apolipoprotein A-I in mouse cerebrospinal fluid derives from the liver and intestine via plasma high-density lipoproteins assembled by ABCA1 and LCAT. FEBS Lett. 2021 Mar;595(6):773-788
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory