Lgals1 MGI Mouse Gene Detail - MGI:96777 - lectin, galactose binding, soluble 1

Symbol

Lgals1
Name

lectin, galactose binding, soluble 1
Synonyms

Gal-1, Galbp, galectin-1, L14, Lect14

Feature Type

protein coding gene
IDs

MGI:96777
NCBI Gene: 16852
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr15:78810925-78814665 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.70 cM, cytoband E
Mapping Data

7 experiments

SNPs within 2kb

189 from dbSNP Build 142
Strain Annotations

18
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96777	protein coding gene	Chr15:78810925-78814665 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022057	protein coding gene	Chr15:79166782-79170177 (+)
A/J	MGP_AJ_G0022018	protein coding gene	Chr15:76439651-76443229 (+)
AKR/J	MGP_AKRJ_G0021993	protein coding gene	Chr15:78555463-78559158 (+)
BALB/cJ	MGP_BALBcJ_G0022024	protein coding gene	Chr15:76408425-76411994 (+)
C3H/HeJ	MGP_C3HHeJ_G0021795	protein coding gene	Chr15:78559834-78563173 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022467	protein coding gene	Chr15:82280160-82285038 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019997	protein coding gene	Chr15:72925506-72929225 (+)
CAST/EiJ	MGP_CASTEiJ_G0021316	protein coding gene	Chr15:79249305-79252876 (+)
CBA/J	MGP_CBAJ_G0021760	protein coding gene	Chr15:84821397-84827771 (+)
DBA/2J	MGP_DBA2J_G0021889	protein coding gene	Chr15:75920734-75924507 (+)
FVB/NJ	MGP_FVBNJ_G0021867	protein coding gene	Chr15:74937062-74940825 (+)
LP/J	MGP_LPJ_G0021957	protein coding gene	Chr15:79359055-79364132 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021887	protein coding gene	Chr15:89989991-89994698 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022481	protein coding gene	Chr15:78576202-78580472 (+)
PWK/PhJ	MGP_PWKPhJ_G0021058	protein coding gene	Chr15:75918569-75923033 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020895	protein coding gene	Chr15:78361532-78365101 (+)
WSB/EiJ	MGP_WSBEiJ_G0021368	protein coding gene	Chr15:78948135-78953432 (+)

Human Ortholog

LGALS1, galectin 1

Vertebrate Orthologs

5

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LGALS1, galectin 1
Synonyms

GAL1, GBP
Links

HGNC:6561

NCBI Gene ID: 3956

neXtProt AC: NX_P09382

UniProt: P09382
Chr Location

22q13.1; chr22:37675636-37679802 (+) GRCh38

MGI Vertebrate Homology

Lgals1 stringent orthology
1 human;1 mouse;1 rat;3 zebrafish
HCOP

vertebrate homology predictions: LGALS1
Gene Tree

Lgals1

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References

1 with disease annotations

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Phenotype Summary

20 phenotypes from 1 allele in 3 genetic backgrounds
7 phenotypes from multigenic genotypes
113 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

68
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

58
Radiation induced

2
Targeted

4
Genomic Mutations

3 involving Lgals1
Incidental Mutations

CvDC
Find Mice (IMSR)

20 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal sensory neurons, altered immune system and delayed muscle development.

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All GO Annotations

39
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1078
Tissues

146
cDNA Data

331
Literature Summary

30

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA LGALS1A

Xenbase lgals1, lgals1.2, lgals1.3

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All Sequences

43
RefSeq

2
UniProt

2
CCDS

CCDS27628.1

Ensembl

ENSMUSG00000068220 (Evidence)
NCBI Gene

16852

			Length	Strain/Species	Flank
genomic	16852	NCBI Gene Model \| MGI Sequence Detail	3741	C57BL/6J	± kb
transcript	NM_008495	RefSeq \| MGI Sequence Detail	817	ZRU/MplStud
polypeptide	P16045	UniProt \| EBI \| MGI Sequence Detail	135	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000009766 galectin-1

(term hierarchy)
PDB

4LBQ
InterPro Domains

IPR013320 Concanavalin A-like lectin/glucanase domain superfamily

IPR001079 Galectin, carbohydrate recognition domain

IPR044156 Galectin-like
GlyGen

P16045 1 site, 1 O-linked glycan (1 site)

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All nucleic 338

Genomic 3

cDNA 332

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-11781, MGD-MRK-11796, MGD-MRK-9961, MGI:2145905

Summaries

All 207

Developmental Gene Expression 30

Diseases 1

Gene Ontology 15

Phenotypes 113
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:353339 Butts JC, et al., A single-cell transcriptomic map of the developing Atoh1 lineage identifies neural fate decisions and neuronal diversity in the hindbrain. Dev Cell. 2024 Aug 19;59(16):2171-2188.e7

TSS for Lgals1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132016	Chr15:78810920-78810935 (+)	3 bp
Tssr132017	Chr15:78812568-78812599 (+)	1,659 bp
Tssr132018	Chr15:78813376-78813408 (+)	2,467 bp
Tssr132019	Chr15:78813844-78813886 (+)	2,940 bp
Tssr132020	Chr15:78814351-78814370 (+)	3,436 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24