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Lhx2 Gene Detail
Summary
  • Symbol
    Lhx2
  • Name
    LIM homeobox protein 2
  • Synonyms
    ap, apterous, Lh-2, LH2A
  • Feature Type
    protein coding gene
  • IDs
    MGI:96785
    NCBI Gene: 16870
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:38229293-38259745 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 24.31 cM, cytoband B
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    534 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96785
 protein coding gene Chr2:38229282-38259747 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025701
 protein coding gene Chr2:37086076-37117411 (+)
A/J MGP_AJ_G0025678
 protein coding gene Chr2:35560748-35591623 (+)
AKR/J MGP_AKRJ_G0025648
 protein coding gene Chr2:36739364-36771172 (+)
BALB/cJ MGP_BALBcJ_G0025673
 protein coding gene Chr2:35614892-35645968 (+)
C3H/HeJ MGP_C3HHeJ_G0025434
 protein coding gene Chr2:36653694-36685039 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026119
 protein coding gene Chr2:38121222-38151344 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023524
 protein coding gene Chr2:34216444-34246697 (+)
CAST/EiJ MGP_CASTEiJ_G0024897
 protein coding gene Chr2:36597805-36629097 (+)
CBA/J MGP_CBAJ_G0025413
 protein coding gene Chr2:39554888-39585177 (+)
DBA/2J MGP_DBA2J_G0025545
 protein coding gene Chr2:35309099-35339512 (+)
FVB/NJ MGP_FVBNJ_G0025507
 protein coding gene Chr2:35176157-35206713 (+)
LP/J MGP_LPJ_G0025632
 protein coding gene Chr2:36969796-37001060 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025538
 protein coding gene Chr2:39170611-39200810 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026177
 protein coding gene Chr2:36628457-36659873 (+)
PWK/PhJ MGP_PWKPhJ_G0024639
 protein coding gene Chr2:35208906-35239323 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024444
 protein coding gene Chr2:36739367-36769249 (+)
WSB/EiJ MGP_WSBEiJ_G0024965
 protein coding gene Chr2:36791955-36826432 (+)



Homology
more
  • Human Ortholog
    LHX2, LIM homeobox 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LHX2, LIM homeobox 2
  • Synonyms
    hLhx2, LH2
  • Links
    NCBI Gene ID: 9355
    neXtProt AC: NX_P50458
    UniProt: P50458

  • Chr Location
    9q33.3; chr9:124001670-124033301 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 8 alleles in 14 genetic backgrounds
    3 phenotypes from multigenic genotypes
    3 images
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit lethality during fetal development and the perinatal period with abnormal liver, telencephalon, olfactory bulb, basal ganglion, and eye morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    27
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1646
  • Tissues
    439
  • cDNA Data
    46
  • Literature Summary
    346
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000247 Ensembl Gene Model | MGI Sequence Detail 30453 C57BL/6J ±  kb
    transcript ENSMUST00000000253 Ensembl | MGI Sequence Detail 2840 Not Applicable  
    polypeptide ENSMUSP00000000253 Ensembl | MGI Sequence Detail 406 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 85
      cDNA 52
      Primer pair 7
      Other 26

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11805
    References
    more
    • Summaries
      All 411
      Developmental Gene Expression 346
      Gene Ontology 27
      Phenotypes 77
    • Earliest
      J:3610 Xu Y, et al., LH-2: a LIM/homeodomain gene expressed in developing lymphocytes and neural cells. Proc Natl Acad Sci U S A. 1993 Jan 1;90(1):227-31
    • Latest
      J:354197 Dumoulin A, et al., A cell-autonomous role for primary cilium-mediated signaling in long-range commissural axon guidance. Development. 2024 Sep 1;151(17)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory