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Lipe Gene Detail
Summary
  • Symbol
    Lipe
  • Name
    lipase, hormone sensitive
  • Synonyms
    4933403G17Rik, HSL
  • Feature Type
    protein coding gene
  • IDs
    MGI:96790
    NCBI Gene: 16890
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:25078952-25097911 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 13.78 cM, cytoband A3
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    477 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96790
 protein coding gene Chr7:25078952-25098135 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031865
 protein coding gene Chr7:23846833-23865894 (-)
A/J MGP_AJ_G0031844
 protein coding gene Chr7:23227249-23246941 (-)
AKR/J MGP_AKRJ_G0031773
 protein coding gene Chr7:23775275-23794259 (-)
BALB/cJ MGP_BALBcJ_G0031851
 protein coding gene Chr7:23440961-23460396 (-)
C3H/HeJ MGP_C3HHeJ_G0031570
 protein coding gene Chr7:24206901-24227581 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032313
 protein coding gene Chr7:24645372-24666020 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029368
 protein coding gene Chr7:24649615-24668724 (-)
CAST/EiJ MGP_CASTEiJ_G0030910
 protein coding gene Chr7:17696277-17717684 (-)
CBA/J MGP_CBAJ_G0031535
 protein coding gene Chr7:25558817-25577869 (-)
DBA/2J MGP_DBA2J_G0031689
 protein coding gene Chr7:23129462-23149052 (-)
FVB/NJ MGP_FVBNJ_G0031642
 protein coding gene Chr7:23131737-23150888 (-)
LP/J MGP_LPJ_G0031768
 protein coding gene Chr7:24145209-24164378 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031679
 protein coding gene Chr7:25259938-25279034 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032345
 protein coding gene Chr7:23480982-23500011 (-)
PWK/PhJ MGP_PWKPhJ_G0030634
 protein coding gene Chr7:18077114-18096763 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030465
 protein coding gene Chr7:14800716-14821476 (-)
WSB/EiJ MGP_WSBEiJ_G0031013
 protein coding gene Chr7:23665337-23686354 (-)



Homology
more
  • Human Ortholog
    LIPE, lipase E, hormone sensitive type
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LIPE, lipase E, hormone sensitive type
  • Synonyms
    AOMS4, FPLD6, HSL, LHS, REH
  • Links
    NCBI Gene ID: 3991
    neXtProt AC: NX_Q05469
    UniProt: Q05469

  • Chr Location
    19q13.2; chr19:42401514-42427388 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human LIPE associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    72 phenotypes from 6 alleles in 10 genetic backgrounds
    6 phenotypes from multigenic genotypes
    6 images
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations of this locus result in abnormal lipid homeostasis and, in some lines, defects in spermatogenesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    21
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    772
  • Tissues
    10
  • cDNA Data
    9
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16890 NCBI Gene Model | MGI Sequence Detail 18960 C57BL/6J ±  kb
    transcript NM_010719 RefSeq | MGI Sequence Detail 3221 ZRU/MplStud  
    polypeptide P54310 UniProt | EBI | MGI Sequence Detail 759 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 3
      cDNA 10
      Primer pair 1
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11812, MGI:1918310
    References
    more
    • Summaries
      All 169
      Developmental Gene Expression 13
      Gene Ontology 21
      Phenotypes 83
    • Earliest
      J:13548 Clamp PA, et al., Linkage relationships between ALPL, ENO1, GPI, PGD, and TGFB1 on porcine chromosome 6. Genomics. 1993 Aug;17(2):324-9
    • Latest
      J:357400 Yu HC, et al., p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL. Nat Metab. 2024 Jan;6(1):94-112
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory