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Tlr4 Gene Detail
Summary
  • Symbol
    Tlr4
  • Name
    toll-like receptor 4
  • Synonyms
    lipopolysaccharide response, Lps, Rasl2-8
  • Feature Type
    protein coding gene
  • IDs
    MGI:96824
    NCBI Gene: 21898
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:66745788-66765338 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 34.66 cM
  • Mapping Data
    32 experiments
Strain
Comparison
more
  • SNPs within 2kb
    703 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96824
 protein coding gene Chr4:66745788-66848521 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028379
 protein coding gene Chr4:65942018-66043001 (+)
A/J MGP_AJ_G0028340
 protein coding gene Chr4:63573802-63677117 (+)
AKR/J MGP_AKRJ_G0028289
 protein coding gene Chr4:65260927-65374494 (+)
BALB/cJ MGP_BALBcJ_G0028360
 protein coding gene Chr4:63770131-63868385 (+)
C3H/HeJ MGP_C3HHeJ_G0028075
 protein coding gene Chr4:65858790-65961712 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028800
 protein coding gene Chr4:68196565-68300432 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026103
 protein coding gene Chr4:60672374-60766344 (+)
CAST/EiJ MGP_CASTEiJ_G0027517
 protein coding gene Chr4:63777108-63880084 (+)
CBA/J MGP_CBAJ_G0028044
 protein coding gene Chr4:70504539-70609901 (+)
DBA/2J MGP_DBA2J_G0028193
 protein coding gene Chr4:63391919-63493347 (+)
FVB/NJ MGP_FVBNJ_G0028159
 protein coding gene Chr4:62619516-62718626 (+)
LP/J MGP_LPJ_G0028292
 protein coding gene Chr4:66197336-66306777 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028188
 protein coding gene Chr4:73730862-73837176 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028836
 protein coding gene Chr4:65411174-65516917 (+)
PWK/PhJ MGP_PWKPhJ_G0027243
 protein coding gene Chr4:61912187-62011437 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027069
 protein coding gene Chr4:62855382-62956142 (+)
WSB/EiJ MGP_WSBEiJ_G0027593
 protein coding gene Chr4:65450926-65554785 (+)



Homology
more
  • Human Ortholog
    TLR4, toll like receptor 4
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TLR4, toll like receptor 4
  • Synonyms
    ARMD10, CD284, TLR-4, TOLL
  • Links
    NCBI Gene ID: 7099
    neXtProt AC: NX_O00206
    UniProt: O00206

  • Chr Location
    9q33.1; chr9:117704175-117724735 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tlr4 mouse models; 35 with human TLR4 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
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Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    136 phenotypes from 18 alleles in 29 genetic backgrounds
    33 phenotypes from multigenic genotypes
    1527 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for spontaneous or targeted mutations are hyporesponsive to bacterial lipopolysaccharide (LPS) and more susceptible to infection by gram negative bacteria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    229
  • GO References
    56
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    781
  • Tissues
    45
  • cDNA Data
    27
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21898 NCBI Gene Model | MGI Sequence Detail 19551 C57BL/6J ±  kb
    transcript NM_021297 RefSeq | MGI Sequence Detail 7891 ZRU/MplStud  
    polypeptide Q9QUK6 UniProt | EBI | MGI Sequence Detail 835 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      Genomic 4
      cDNA 28
      Primer pair 8

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11879, MGD-MRK-26042
    References
    more
    • Summaries
      All 2254
      Developmental Gene Expression 28
      Diseases 1
      Gene Ontology 56
      Phenotypes 1527
    • Earliest
      J:5087 Sultzer BM, Genetic control of leucocyte responses to endotoxin. Nature. 1968 Sep 21;219(160):1253-4
    • Latest
      J:352411 Wei C, et al., Brain endothelial GSDMD activation mediates inflammatory BBB breakdown. Nature. 2024 May;629(8013):893-900
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory