Lse Cytogenetic Marker Detail

Summary

• Symbol
  Lse
• Name
  low set ears

• Feature Type
  chromosomal duplication
• IDs
  MGI:96831
  NCBI Gene: 103996

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 7, Syntenic

Human Diseases

• Diseases
  1 with Lse mouse models

Human Disease

Mouse Models

chromosomal duplication syndrome

IDs

chromosomal duplication syndrome      

DOID:0060429

View 1 model

Mouse Models

Human Disease Modeled: chromosomal duplication syndrome

Allelic Composition	Genetic Background	Reference	Phenotypes
Lse/Lse+	B6C3Fe a/a-Lse/J	J:338204	View

Click on a disease name to see all genes associated with that disease.

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  29 phenotypes from 1 allele in 1 genetic background
  7 phenotypes from multigenic genotypes
  3 phenotype references
  

• All Mutations and Alleles
  1
• Spontaneous
  1
• Find Mice (IMSR)
  1 strains or lines available

Mutations in this gene affect external ear formation and eye development, and result in retarded growth and shortened life span.

Sequences &
Gene Models

• NCBI Gene
  103996

Other
Accession IDs

MGD-MRK-11890

References

• Summaries
  All 5

  Diseases 1

  Phenotypes 3
• Earliest
  J:8618 Theiler K, et al., Low set ears (Lse), a new mutation of the house mouse. Anat Embryol (Berl). 1986;175(2):241-6
• Latest
  J:338204 Luzzio A, et al., The spontaneous mouse mutant low set ears (Lse) is caused by tandem duplication of Fgf3 and Fgf4. Mamm Genome. 2023 Jun 21;