Lsr1 QTL Detail

Summary

• Symbol
  Lsr1
• Name
  listeria resistance
• Synonyms
  Lr-1, Lsr-1

• Feature Type
  QTL
• IDs
  MGI:96833
  NCBI Gene: 109745

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome 2, cM position of peak correlated region/marker: Syntenic
• Mapping Data
  3 experiments

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  2 phenotypes from 2 alleles in 1 genetic background
  1 phenotype reference
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

This locus controls resistance to Listeria monocytogenes infection. C57BL/6, C57BL/10, NZB and SJL are resistant; BALB/c, CBA, DBA/1, DBA/2, A/J, LP, RIII, WB, 129 and C3H are susceptible. Heterozygotes are resistant. Lsr1 and Ack have the same strain distribution and may be identical.

Sequences &
Gene Models

• NCBI Gene
  109745

Other
Accession IDs

MGD-MRK-11885, MGD-MRK-11894, MGD-MRK-11895

References

• Summaries
  All 11

  Phenotypes 1
• Earliest
  J:5965 Cheers C, et al., Resistance and susceptibility of mice to bacterial infection: genetics of listeriosis. Infect Immun. 1978 Mar;19(3):755-62
• Latest
  J:7932 Czuprynski CJ, et al., Genetically determined resistance to listeriosis is associated with increased accumulation of inflammatory neutrophils and macrophages which have enhanced listericidal activity. Immunology. 1985 Jul;55(3):511-8