Lus QTL Detail

Summary

• Symbol
  Lus
• Name
  lymphoid cytostasis suppressor

• Feature Type
  QTL
• IDs
  MGI:96852
  NCBI Gene: 107487

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  1 phenotype from multigenic genotypes
  2 phenotype references
  

• All Mutations and Alleles
  2
• QTL
  2
• Find Mice (IMSR)
  0 strains or lines available

Lus induces sensitization of T- and B-cells that cause cytostasis of target tumor cells. The dominant B10.D2 allele suppresses production of the effector cells; the BALB/c allele enhances production. Lus interacts with an Arp mutant to produce an autoimmune lymphoid/erythroid hyperplastic disorder.

Sequences &
Gene Models

• NCBI Gene
  107487

Other
Accession IDs

MGD-MRK-11930

References

• Summaries
  All 3

  Phenotypes 2
• Earliest
  J:6122 De Giorgi L, et al., Modification of the anti-tumour immune response by suppressor gene products of lymphoid cells. Immunology. 1979 Apr;36(4):711-8
• Latest
  J:7273 Matossian-Rogers A, et al., Alloimmune interactions of a lymphoproliferative disease-inducer gene Arp and linkage to Pep-7. Immunogenetics. 1983;18(6):639-48