Ly6d MGI Mouse Gene Detail - MGI:96881 - lymphocyte antigen 6 family member D

Symbol

Ly6d
Name

lymphocyte antigen 6 family member D
Synonyms

Ly-61, Ly61, Thb

Feature Type

protein coding gene
IDs

MGI:96881
NCBI Gene: 17068
Member of

Ly6 cluster
Alliance

gene page
Transcription Start Sites

2 TSS

Sequence Map

Chr15:74633905-74635416 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 34.27 cM
Mapping Data

12 experiments

SNPs within 2kb

108 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96881	protein coding gene	Chr15:74633905-74635469 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0021937	protein coding gene	Chr15:74548003-74549574 (-)
A/J	MGP_AJ_G0021896	protein coding gene	Chr15:71890561-71892125 (-)
AKR/J	MGP_AKRJ_G0021878	protein coding gene	Chr15:73727633-73729197 (-)
BALB/cJ	MGP_BALBcJ_G0021903	protein coding gene	Chr15:71896794-71898358 (-)
C3H/HeJ	MGP_C3HHeJ_G0021676	protein coding gene	Chr15:73880909-73882473 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022343	protein coding gene	Chr15:77358739-77360303 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019879	protein coding gene	Chr15:68293453-68295009 (-)
CAST/EiJ	MGP_CASTEiJ_G0021195	protein coding gene	Chr15:74701360-74702931 (-)
CBA/J	MGP_CBAJ_G0021642	protein coding gene	Chr15:79897577-79899141 (-)
DBA/2J	MGP_DBA2J_G0021767	protein coding gene	Chr15:71481345-71482909 (-)
FVB/NJ	MGP_FVBNJ_G0021749	protein coding gene	Chr15:70530376-70531940 (-)
LP/J	MGP_LPJ_G0021839	protein coding gene	Chr15:74604404-74605968 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021772	protein coding gene	Chr15:85208982-85210546 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022364	protein coding gene	Chr15:74116836-74118400 (-)
PWK/PhJ	MGP_PWKPhJ_G0020936	protein coding gene	Chr15:71591986-71593557 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0020777	protein coding gene	Chr15:74000606-74002178 (-)
WSB/EiJ	MGP_WSBEiJ_G0021247	protein coding gene	Chr15:74126159-74127723 (-)

Human Ortholog

LY6D, lymphocyte antigen 6 family member D

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LY6D, lymphocyte antigen 6 family member D
Synonyms

E48, Ly-6D
Links

HGNC:13348

NCBI Gene ID: 8581

neXtProt AC: NX_Q14210

UniProt: Q14210
Chr Location

8q24.3; chr8:142784882-142786539 (-) GRCh38

MGI Vertebrate Homology

Ly6d stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LY6D
Gene Tree

Ly6d

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
30 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

3
Endonuclease-mediated

4
Radiation induced

2
Targeted

2
Genomic Mutations

5 involving Ly6d
Find Mice (IMSR)

11 strains or lines available

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All GO Annotations

7
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

750
Tissues

10
cDNA Data

47
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

28
RefSeq

2
UniProt

1
CCDS

CCDS27531.1

Ensembl

ENSMUSG00000034634 (Evidence)
NCBI Gene

17068

			Length	Strain/Species	Flank
genomic	17068	NCBI Gene Model \| MGI Sequence Detail	1512	C57BL/6J	± kb
transcript	NM_010742	RefSeq \| MGI Sequence Detail	694	ZRU/MplStud
polypeptide	P35459	UniProt \| EBI \| MGI Sequence Detail	127	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000009988 lymphocyte antigen 6D

(term hierarchy)
InterPro Domains

IPR018363 CD59 antigen, conserved site

IPR016054 Ly-6 antigen/uPA receptor-like

IPR042339 Lymphocyte antigen 6D

IPR045860 Snake toxin-like superfamily

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All nucleic 52

Genomic 3

cDNA 47

Primer pair 1

Other 1

Microarray probesets 3

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MGD-MRK-12003, MGD-MRK-12046, MGD-MRK-15080

Summaries

All 70

Developmental Gene Expression 7

Diseases 1

Gene Ontology 5

Phenotypes 30
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Ly6d:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr134746	Chr15:74635553-74635597 (-)	-159 bp
Tssr134745	Chr15:74635423-74635437 (-)	-14 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24