Lyb3 Gene Detail

Summary

• Symbol
  Lyb3
• Name
  B-lymphocyte antigen 3
• Synonyms
  Lyb-3

• Feature Type
  heritable phenotypic marker
• IDs
  MGI:96886
  NCBI Gene: 104258
• Alliance
  gene page

Location &
Maps

• Sequence Map
  Genome coordinates not available from the current reference assembly.

• Genetic Map
  Chromosome Unknown

Mutations,
Alleles, and
Phenotypes

This locus encodes an antigen on late maturing splenic B cells and may be involved in B cell terminal differentiation. Antigen is present in all tested strains except CBA/N. This lack of antigen is attributed to a Btk mutation (xid) carried by CBA/N.

Sequences &
Gene Models

• NCBI Gene
  104258

Other
Accession IDs

MGD-MRK-12055, MGD-MRK-12061

References

• Summaries
  All 5
• Earliest
  J:5743 Huber B, et al., Identification of a B-cell surface structure involved in antigen-dependent triggering: absence of this structure on B cells from CBA/N mutant mice. J Exp Med. 1977 Jan 1;145(1):10-20
• Latest
  J:6941 Kemp JD, et al., Lyb3: a B cell surface antigen associated with triggering secretory differentiation. Immunol Rev. 1982;69:127-40