Lyl1 MGI Mouse Gene Detail - MGI:96891 - lymphoblastomic leukemia 1

Symbol

Lyl1
Name

lymphoblastomic leukemia 1
Synonyms

bHLHa18, Lyl-1

Feature Type

protein coding gene
IDs

MGI:96891
NCBI Gene: 17095
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr8:85428078-85431569 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 41.02 cM
Mapping Data

14 experiments

SNPs within 2kb

99 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96891	protein coding gene	Chr8:85428051-85432876 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033868	protein coding gene	Chr8:85614232-85617489 (+)
A/J	MGP_AJ_G0033851	protein coding gene	Chr8:82243916-82247173 (+)
AKR/J	MGP_AKRJ_G0033777	protein coding gene	Chr8:84677787-84681044 (+)
BALB/cJ	MGP_BALBcJ_G0033844	protein coding gene	Chr8:82366571-82369828 (+)
C3H/HeJ	MGP_C3HHeJ_G0033554	protein coding gene	Chr8:85299356-85302613 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034364	protein coding gene	Chr8:88906466-88909724 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031306	protein coding gene	Chr8:76036562-76039817 (+)
CAST/EiJ	MGP_CASTEiJ_G0032884	protein coding gene	Chr8:84722456-84725695 (+)
CBA/J	MGP_CBAJ_G0033530	protein coding gene	Chr8:91949423-91952676 (+)
DBA/2J	MGP_DBA2J_G0033683	protein coding gene	Chr8:81884808-81888065 (+)
FVB/NJ	MGP_FVBNJ_G0033631	protein coding gene	Chr8:80822184-80825441 (+)
LP/J	MGP_LPJ_G0033775	protein coding gene	Chr8:85728589-85731846 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033673	protein coding gene	Chr8:94494564-94497821 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034381	protein coding gene	Chr8:84667589-84670847 (+)
PWK/PhJ	MGP_PWKPhJ_G0032588	protein coding gene	Chr8:81127352-81130610 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032424	protein coding gene	Chr8:83478645-83481895 (+)
WSB/EiJ	MGP_WSBEiJ_G0032997	protein coding gene	Chr8:85098366-85101623 (+)

Human Ortholog

LYL1, LYL1 basic helix-loop-helix family member

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LYL1, LYL1 basic helix-loop-helix family member
Synonyms

bHLHa18
Links

HGNC:6734

NCBI Gene ID: 4066

neXtProt AC: NX_P12980

UniProt: P12980
Chr Location

19p13.13; chr19:13099033-13103161 (-) GRCh38

MGI Vertebrate Homology

Lyl1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LYL1
Gene Tree

Lyl1

Diseases

1 with human LYL1 associations

				Human Disease	Mouse Models
				T-cell acute lymphoblastic leukemia IDs T-cell acute lymphoblastic leukemia DOID:5603 MESH:D015458 UMLS_CUI:C0023492

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

7 phenotypes from 2 alleles in 2 genetic backgrounds
52 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

2
Radiation induced

1
Targeted

4
Transgenic

1
Genomic Mutations

2 involving Lyl1
Incidental Mutations

APF
Find Mice (IMSR)

10 strains or lines available

Mice with mutation of this gene are vaible and fertile. Defects in production and differentiation of progenitor cells are observed, along with impaired ability of fetal liver or bone marrow cells in reconstituting B and T lineages after transplant.

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

789
Tissues

38
cDNA Data

33
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase lyl1

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All Sequences

47
RefSeq

6
UniProt

4
CCDS

CCDS22476.1

Ensembl

ENSMUSG00000034041 (Evidence)
NCBI Gene

17095

			Length	Strain/Species	Flank
genomic	ENSMUSG00000034041	Ensembl Gene Model \| MGI Sequence Detail	3492	C57BL/6J	± kb
transcript	ENSMUST00000037165	Ensembl \| MGI Sequence Detail	1714	Not Applicable
polypeptide	ENSMUSP00000046010	Ensembl \| MGI Sequence Detail	278	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010001 protein lyl-1

(term hierarchy)
InterPro Domains

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR040238 Helix-loop-helix protein TAL-like

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
GlyGen

P27792 1 site, 1 O-linked glycan (1 site)

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All nucleic 38

Genomic 5

cDNA 33

Microarray probesets 4

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MGD-MRK-12067, MGD-MRK-12068

Summaries

All 95

Developmental Gene Expression 9

Gene Ontology 6

Phenotypes 52
Earliest

J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
Latest

J:348117 Okuma H, et al., N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on alpha-dystroglycan and prevents muscular dystrophy. Elife. 2023 Feb 1;12

TSS for Lyl1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78433	Chr8:85428059-85428126 (+)	15 bp
Tssr78434	Chr8:85428391-85428398 (+)	317 bp
Tssr78435	Chr8:85428400-85428427 (+)	336 bp
Tssr78436	Chr8:85428432-85428456 (+)	366 bp
Tssr78437	Chr8:85428501-85428511 (+)	428 bp
Tssr78438	Chr8:85428536-85428539 (+)	460 bp
Tssr78439	Chr8:85430020-85430044 (+)	1,954 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24