Lyz2 MGI Mouse Gene Detail - MGI:96897

Symbol

Lyz2
Name

lysozyme 2
Synonyms

Lys, Lysm, Lyzs, Lzm, Lzm-s1, Lzp

Feature Type

protein coding gene
IDs

MGI:96897
NCBI Gene: 17105
Alliance

gene page
Transcription Start Sites

21 TSS

Sequence Map

Chr10:117113446-117118177 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 65.34 cM
Mapping Data

5 experiments

SNPs within 2kb

324 from dbSNP Build 142
Strain Annotations

15

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96897	protein coding gene	Chr10:117113236-117118226 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017757	protein coding gene	Chr10:120164478-120186569 (-)
A/J	MGP_AJ_G0017733	protein coding gene	Chr10:115481562-115487121 (-)
AKR/J	MGP_AKRJ_G0017695	protein coding gene	Chr10:118855540-118860584 (-)
BALB/cJ	MGP_BALBcJ_G0017696	protein coding gene	Chr10:115878197-115883811 (-)
C3H/HeJ	MGP_C3HHeJ_G0017521	protein coding gene	Chr10:119100069-119115936 (-)
C57BL/6NJ	no annotation
CAROLI/EiJ	MGP_CAROLIEiJ_G0015831	protein coding gene	Chr10:110047620-110052290 (-)
CAST/EiJ	no annotation
CBA/J	MGP_CBAJ_G0017490	protein coding gene	Chr10:129225645-129227199 (-)
DBA/2J	MGP_DBA2J_G0017595	protein coding gene	Chr10:114627898-114634914 (-)
FVB/NJ	MGP_FVBNJ_G0017590	protein coding gene	Chr10:113585818-113590041 (-)
LP/J	no annotation
NOD/ShiLtJ	MGP_NODShiLtJ_G0017619	protein coding gene	Chr10:132053455-132060195 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018191	protein coding gene	Chr10:118926170-118932954 (-)
PWK/PhJ	MGP_PWKPhJ_G0016864	protein coding gene	Chr10:114715019-114720961 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016654	protein coding gene	Chr10:117702179-117705892 (-)
WSB/EiJ	MGP_WSBEiJ_G0017143	protein coding gene	Chr10:119109953-119114333 (-)

Human Ortholog

LYZ, lysozyme

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LYZ, lysozyme
Synonyms

AMYLD5, LYZF1, LZM
Links

HGNC:6740

NCBI Gene ID: 4069

neXtProt AC: NX_P61626

UniProt: P61626
Chr Location

12q15; chr12:69348381-69354234 (+) GRCh38

MGI Vertebrate Homology

Lyz2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LYZ
Gene Tree

Lyz2

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Mutations/Alleles

1 with disease annotations

References

5 with disease annotations

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
403 phenotypes from multigenic genotypes
2 images
2762 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

11
Targeted

6
Genomic Mutations

1 involving Lyz2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

40 strains or lines available
Comparison Matrix

Gene Expression + Phenotype
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

Mice homozygous for a reporter allele exhibit increased inflammation in response to Micrococcus luteus and its peptidoglycan, despite partial compensatory expression of lysozyme P in macrophages.

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All GO Annotations

25
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

21
cDNA Data

17
Literature Summary

40

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

39
RefSeq

2
UniProt

2
CCDS

CCDS48694.1

Ensembl

ENSMUSG00000069516 (Evidence)
NCBI Gene

17105

			Length	Strain/Species	Flank
genomic	17105	NCBI Gene Model \| MGI Sequence Detail	4732	C57BL/6J	± kb
transcript	NM_017372	RefSeq \| MGI Sequence Detail	1057	ZRU/MplStud
polypeptide	P08905	UniProt \| EBI \| MGI Sequence Detail	148	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010030 lysozyme C-2

(term hierarchy)
PDB

1IVM
EC

3.2.1.17
InterPro Domains

IPR001916 Glycoside hydrolase, family 22

IPR019799 Glycoside hydrolase family 22 domain

IPR000974 Glycoside hydrolase, family 22, lysozyme

IPR023346 Lysozyme-like domain superfamily

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All nucleic 21

cDNA 17

Primer pair 3

Other 1

Microarray probesets 4

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MGD-MRK-12083, MGD-MRK-12085, MGI:2143581, MGI:96899

Summaries

All 2845

Developmental Gene Expression 40

Diseases 5

Gene Ontology 7

Phenotypes 2762
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:358010 Chen Y, et al., MiR-106a-5p targets PFKFB3 and improves sepsis through regulating macrophage pyroptosis and inflammatory response. J Biol Chem. 2024 Jun;300(6):107334

TSS for Lyz2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99432	Chr10:117118337-117118346 (-)	-165 bp
Tssr99431	Chr10:117118290-117118298 (-)	-117 bp
Tssr99430	Chr10:117118234-117118272 (-)	-76 bp
Tssr99429	Chr10:117118227-117118232 (-)	-53 bp
Tssr99428	Chr10:117118167-117118185 (-)	1 bp
Tssr99427	Chr10:117118148-117118162 (-)	22 bp
Tssr99426	Chr10:117116907-117116910 (-)	1,268 bp
Tssr99425	Chr10:117116685-117116720 (-)	1,474 bp
Tssr99424	Chr10:117116640-117116671 (-)	1,521 bp
Tssr99423	Chr10:117116572-117116609 (-)	1,586 bp
Tssr99422	Chr10:117114810-117114823 (-)	3,360 bp
Tssr99421	Chr10:117114078-117114101 (-)	4,087 bp
Tssr99420	Chr10:117114004-117114025 (-)	4,162 bp
Tssr99419	Chr10:117113932-117113967 (-)	4,227 bp
Tssr99418	Chr10:117113917-117113929 (-)	4,254 bp
Tssr99417	Chr10:117113903-117113910 (-)	4,270 bp
Tssr99416	Chr10:117113791-117113835 (-)	4,364 bp
Tssr99415	Chr10:117113741-117113768 (-)	4,422 bp
Tssr99414	Chr10:117113658-117113708 (-)	4,494 bp
Tssr99413	Chr10:117113569-117113594 (-)	4,595 bp
Tssr99412	Chr10:117113508-117113541 (-)	4,652 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24