Mxd1 MGI Mouse Gene Detail - MGI:96908 - MAX dimerization protein 1

Symbol

Mxd1
Name

MAX dimerization protein 1
Synonyms

Mad, Mad1

Feature Type

protein coding gene
IDs

MGI:96908
NCBI Gene: 17119
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr6:86624026-86646099 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 37.75 cM
Mapping Data

7 experiments

SNPs within 2kb

487 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96908	protein coding gene	Chr6:86624024-86646143 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0030980	protein coding gene	Chr6:87953655-87975400 (-)
A/J	MGP_AJ_G0030946	protein coding gene	Chr6:84553265-84575034 (-)
AKR/J	MGP_AKRJ_G0030877	protein coding gene	Chr6:87000510-87023472 (-)
BALB/cJ	MGP_BALBcJ_G0030959	protein coding gene	Chr6:84564742-84586882 (-)
C3H/HeJ	MGP_C3HHeJ_G0030751	protein coding gene	Chr6:97441087-97462856 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0031416	protein coding gene	Chr6:90334972-90356803 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028600	protein coding gene	Chr6:82734789-82757206 (-)
CAST/EiJ	MGP_CASTEiJ_G0030068	protein coding gene	Chr6:87072630-87094531 (-)
CBA/J	MGP_CBAJ_G0030643	protein coding gene	Chr6:93886306-93908164 (-)
DBA/2J	MGP_DBA2J_G0030799	protein coding gene	Chr6:83870755-83892506 (-)
FVB/NJ	MGP_FVBNJ_G0030752	protein coding gene	Chr6:83054072-83075869 (-)
LP/J	MGP_LPJ_G0030876	protein coding gene	Chr6:87984647-88006345 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030785	protein coding gene	Chr6:98003902-98026398 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031443	protein coding gene	Chr6:86839786-86861431 (-)
PWK/PhJ	MGP_PWKPhJ_G0029783	protein coding gene	Chr6:82812569-82834346 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0029611	protein coding gene	Chr6:85677742-85699289 (-)
WSB/EiJ	MGP_WSBEiJ_G0030149	protein coding gene	Chr6:87306427-87328076 (-)

Human Ortholog

MXD1, MAX dimerization protein 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MXD1, MAX dimerization protein 1
Synonyms

BHLHC58, MAD, MAD1
Links

HGNC:6761

NCBI Gene ID: 4084

neXtProt AC: NX_Q05195

UniProt: Q05195
Chr Location

2p13.3; chr2:69897688-69942945 (+) GRCh38

MGI Vertebrate Homology

Mxd1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MXD1
Gene Tree

Mxd1

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Spontaneous

1
Targeted

3
Genomic Mutations

1 involving Mxd1
Find Mice (IMSR)

17 strains or lines available

Mice homozygous for a knock-out allele exhibit altered myelopoiesis, increased proliferative potential of bone marrow granulocytic precursors, increased sensitivity of myeloid cells to apoptosis-inducing stimuli, and inhibited cell cycle withdrawal during a late stage of granulocyte differentiation.

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All GO Annotations

17
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

917
Tissues

199
cDNA Data

21
Literature Summary

13

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MXD1

Xenbase mxd1

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All Sequences

57
RefSeq

5
UniProt

6
CCDS

CCDS51835.1

Ensembl

ENSMUSG00000001156 (Evidence)
NCBI Gene

17119

			Length	Strain/Species	Flank
genomic	17119	NCBI Gene Model \| MGI Sequence Detail	22074	C57BL/6J	± kb
transcript	NR_176938	RefSeq \| MGI Sequence Detail	4685	ZRU/MplStud
polypeptide	P50538	UniProt \| EBI \| MGI Sequence Detail	227	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000010790 max dimerization protein 1

(term hierarchy)
InterPro Domains

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR040157 Max dimerization protein 1, basic Helix-Loop-Helix-zipper domain

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

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All nucleic 27

cDNA 24

Primer pair 2

Other 1

Microarray probesets 6

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MGD-MRK-12100, MGI:2141648

Summaries

All 62

Developmental Gene Expression 13

Gene Ontology 6

Phenotypes 11
Earliest

J:19396 Ayer DE, et al., Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity. Cell. 1993 Jan 29;72(2):211-22
Latest

J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)

TSS for Mxd1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr61832	Chr6:86646118-86646146 (-)	-33 bp
Tssr61831	Chr6:86646092-86646107 (-)	-1 bp
Tssr61830	Chr6:86627142-86627155 (-)	18,950 bp
Tssr61829	Chr6:86626911-86626964 (-)	19,161 bp
Tssr61828	Chr6:86626408-86626411 (-)	19,689 bp
Tssr61827	Chr6:86626021-86626024 (-)	20,076 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24