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Maf Gene Detail
Summary
  • Symbol
    Maf
  • Name
    MAF bZIP transcription factor
  • Synonyms
    2810401A20Rik, A230108G15Rik, c-maf
  • Feature Type
    protein coding gene
  • IDs
    MGI:96909
    NCBI Gene: 17132
  • Alliance
    gene page
  • Transcription Start Sites
    43 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:116429992-116433633 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 62.61 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    97 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96909
 protein coding gene Chr8:116409681-116434533 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034162
 protein coding gene Chr8:118728440-118755365 (-)
A/J MGP_AJ_G0034142
 protein coding gene Chr8:113902743-113928460 (-)
AKR/J MGP_AKRJ_G0034069
 protein coding gene Chr8:117214010-117240387 (-)
BALB/cJ MGP_BALBcJ_G0034136
 protein coding gene Chr8:114086923-114111765 (-)
C3H/HeJ MGP_C3HHeJ_G0033847
 protein coding gene Chr8:117934462-117959307 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034656
 protein coding gene Chr8:122752795-122777709 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031598
 protein coding gene Chr8:106893426-106899779 (-)
CAST/EiJ MGP_CASTEiJ_G0033174
 protein coding gene Chr8:117689596-117714436 (-)
CBA/J MGP_CBAJ_G0033820
 protein coding gene Chr8:127126990-127157612 (-)
DBA/2J MGP_DBA2J_G0033976
 protein coding gene Chr8:113126905-113151740 (-)
FVB/NJ MGP_FVBNJ_G0033919
 protein coding gene Chr8:112111901-112136745 (-)
LP/J MGP_LPJ_G0034065
 protein coding gene Chr8:118863990-118889516 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033966
 protein coding gene Chr8:129811982-129838230 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034674
 protein coding gene Chr8:117279153-117303947 (-)
PWK/PhJ MGP_PWKPhJ_G0032876
 protein coding gene Chr8:112817178-112842765 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032716
 protein coding gene Chr8:115939053-115967642 (-)
WSB/EiJ MGP_WSBEiJ_G0033290
 protein coding gene Chr8:117988259-118014145 (-)



Homology
more
  • Human Ortholog
    MAF, MAF bZIP transcription factor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAF, MAF bZIP transcription factor
  • Synonyms
    AYGRP, CCA4, c-MAF, CTRCT21
  • Links
    NCBI Gene ID: 4094
    neXtProt AC: NX_O75444
    UniProt: O75444

  • Chr Location
    16q23.2; chr16:79202622-79600737 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Maf mouse models; 3 with human MAF associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
 View 2 models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    72 phenotypes from 10 alleles in 9 genetic backgrounds
    1 phenotype from multigenic genotypes
    2 images
    67 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes show increased mortality at embryonic day 17.5-18.5, low postnatal survival, abnormal differentiation of lens fiber cells causing microphthalmia, defective lens development and impaired IL4 production by CD4+ T cells and natural killer cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1023
  • Tissues
    152
  • cDNA Data
    24
  • Literature Summary
    90
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17132 NCBI Gene Model | MGI Sequence Detail 3642 C57BL/6J ±  kb
    transcript NM_001025577 RefSeq | MGI Sequence Detail 3642 Not Specified  
    polypeptide P54843 UniProt | EBI | MGI Sequence Detail 370 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 26
      Primer pair 7
      Other 6

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-12101, MGI:1925586, MGI:2142746, MGI:2444997
    References
    more
    • Summaries
      All 210
      Developmental Gene Expression 90
      Diseases 2
      Gene Ontology 17
      Phenotypes 67
    • Earliest
      J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
    • Latest
      J:354960 Chang Y, et al., TGF-beta specifies T(FH) versus T(H)17 cell fates in murine CD4(+) T cells through c-Maf. Sci Immunol. 2024 Mar;9(93):eadd4818
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory