Maff MGI Mouse Gene Detail - MGI:96910 - Maf bZIP transcription factor F

Symbol

Maff
Name

Maf bZIP transcription factor F

Feature Type

protein coding gene
IDs

MGI:96910
NCBI Gene: 17133
Alliance

genome feature page
Transcription Start Sites

13 TSS

Sequence Map

Chr15:79230821-79243276 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 37.70 cM
Mapping Data

1 experiment

SNPs within 2kb

355 from dbSNP Build 142
Strain Annotations

19
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96910	protein coding gene	Chr15:79230813-79243278 (+)
129S1/SvImJ	ENSMUSG00200050113	protein coding gene	Chr15:76342528-76354979 (+)
A/J	ENSMUSG00195046932	protein coding gene	Chr15:76285322-76297776 (+)
AKR/J	ENSMUSG00220050866	protein coding gene	Chr15:76328717-76341171 (+)
BALB/cJ	ENSMUSG00180049414	protein coding gene	Chr15:76162305-76174759 (+)
C3H/HeJ	ENSMUSG00175048770	protein coding gene	Chr15:76473546-76486000 (+)
C57BL/6NJ	ENSMUSG00215052573	protein coding gene	Chr15:76241182-76253637 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020012	protein coding gene	Chr15:73347718-73359115 (+)
CAST/EiJ	ENSTCUG00005041523	protein coding gene	Chr15:75784929-75797386 (+)
CBA/J	ENSMUSG00210038395	protein coding gene	Chr15:76248689-76261143 (+)
DBA/2J	ENSMUSG00185039579	protein coding gene	Chr15:76258574-76271028 (+)
FVB/NJ	ENSMUSG00205024945	protein coding gene	Chr15:75978411-75990865 (+)
JF1/MsJ	ENSUMUG00000053592	protein coding gene	Chr15:75837329-75849772 (+)
LP/J	ENSMUSG00230051578	protein coding gene	Chr15:79590963-79603414 (+)
NOD/ShiLtJ	ENSMUSG00190040719	protein coding gene	Chr15:76268416-76280867 (+)
NZO/HlLtJ	ENSMUSG00225052096	protein coding gene	Chr15:79920628-79933087 (+)
PWK/PhJ	ENSLUMG00010051897	protein coding gene	Chr15:76057128-76069587 (+)
SPRET/EiJ	ENSMSPG00010041370	protein coding gene	Chr15:77718806-77731146 (+)
WSB/EiJ	ENSIUOG00005039727	protein coding gene	Chr15:76324954-76337413 (+)

Human Ortholog

MAFF, MAF bZIP transcription factor F

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAFF, MAF bZIP transcription factor F
Synonyms

hMafF, U-MAF
Links

HGNC:6780

NCBI Gene ID: 23764

UniProt: Q9ULX9
Chr Location

22q13.1; chr22:38200767-38216511 (+) GRCh38

MGI Vertebrate Homology

Maff stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAFF
Gene Tree

Maff

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References

1 with disease annotations

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Phenotype Summary

1 phenotype from 2 alleles in 1 genetic background
36 phenotype references

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

4
Gene trapped

4
Radiation induced

2
Targeted

6
Genomic Mutations

3 involving Maff
Find Mice (IMSR)

7 strains or lines available

Homozygous null mice are viable and fertile and show no obvious functional deficiencies.

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All GO Annotations

27
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

777
Tissues

172
cDNA Data

24
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MAFF

ZFIN maff

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All Sequences

57
RefSeq

14
UniProt

5
CCDS

CCDS27638.1

Ensembl

ENSMUSG00000042622 (Evidence)
NCBI Gene

17133

			Length	Strain/Species	Flank
genomic	ENSMUSG00000042622	Ensembl Gene Model \| MGI Sequence Detail	12456	C57BL/6J	± kb
transcript	ENSMUST00000163691	Ensembl \| MGI Sequence Detail	1902	Not Applicable
polypeptide	ENSMUSP00000131628	Ensembl \| MGI Sequence Detail	156	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000010049 transcription factor MafF

(term hierarchy)
InterPro Domains

IPR004827 Basic-leucine zipper domain

IPR004826 Basic leucine zipper domain, Maf-type

IPR046347 Basic-leucine zipper domain superfamily

IPR024874 Transcription factor Maf family

IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily

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All nucleic 28

Genomic 1

cDNA 24

Primer pair 3

Microarray probesets 4

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MGD-MRK-12102

Summaries

All 71

Developmental Gene Expression 10

Diseases 1

Gene Ontology 7

Phenotypes 36
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:387680 Ahn B, et al., Disorganization of Transcriptional Regulation and Alteration of Keratin Family Gene Expression in Hairy Ear Mice. Genes (Basel). 2026 Jan 31;17(2)

TSS for Maff:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132083	Chr15:79230808-79230817 (+)	-8 bp
Tssr132084	Chr15:79231734-79231756 (+)	924 bp
Tssr132085	Chr15:79231767-79231778 (+)	952 bp
Tssr132086	Chr15:79231783-79231798 (+)	970 bp
Tssr132087	Chr15:79231799-79231814 (+)	986 bp
Tssr132088	Chr15:79231830-79231844 (+)	1,016 bp
Tssr132089	Chr15:79232137-79232230 (+)	1,363 bp
Tssr132090	Chr15:79232329-79232354 (+)	1,521 bp
Tssr132091	Chr15:79232591-79232607 (+)	1,778 bp
Tssr132092	Chr15:79232621-79232632 (+)	1,806 bp
Tssr132093	Chr15:79242059-79242070 (+)	11,244 bp
Tssr132094	Chr15:79242590-79242595 (+)	11,772 bp
Tssr132095	Chr15:79242640-79242653 (+)	11,826 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24