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Max Gene Detail
Summary
  • Symbol
    Max
  • Name
    Max protein
  • Synonyms
    bHLHd4, bHLHd5, bHLHd6, bHLHd7, bHLHd8
  • Feature Type
    protein coding gene
  • IDs
    MGI:96921
    NCBI Gene: 17187
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:76984043-77008975 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 33.78 cM, cytoband D1-D3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    569 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96921
 protein coding gene Chr12:76984043-77009123 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019867
 protein coding gene Chr12:77085199-77112907 (-)
A/J MGP_AJ_G0019825
 protein coding gene Chr12:74141873-74166834 (-)
AKR/J MGP_AKRJ_G0019800
 protein coding gene Chr12:76395364-76420302 (-)
BALB/cJ MGP_BALBcJ_G0019804
 protein coding gene Chr12:74617556-74644181 (-)
C3H/HeJ MGP_C3HHeJ_G0019610
 protein coding gene Chr12:76858609-76883744 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020256
 protein coding gene Chr12:79432063-79457338 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017874
 protein coding gene Chr12:71475763-71498178 (-)
CAST/EiJ MGP_CASTEiJ_G0019161
 protein coding gene Chr12:71665281-71691701 (-)
CBA/J MGP_CBAJ_G0019580
 protein coding gene Chr12:82517697-82545711 (-)
DBA/2J MGP_DBA2J_G0019696
 protein coding gene Chr12:74008342-74033493 (-)
FVB/NJ MGP_FVBNJ_G0019683
 protein coding gene Chr12:72830502-72855576 (-)
LP/J MGP_LPJ_G0019768
 protein coding gene Chr12:77059355-77084276 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019722
 protein coding gene Chr12:85494500-85519492 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020292
 protein coding gene Chr12:75874050-75898985 (-)
PWK/PhJ MGP_PWKPhJ_G0018927
 protein coding gene Chr12:68360488-68385644 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018721
 protein coding gene Chr12:70366408-70391122 (-)
WSB/EiJ MGP_WSBEiJ_G0019213
 protein coding gene Chr12:76485148-76510168 (-)



Homology
more
  • Human Ortholog
    MAX, MYC associated factor X
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAX, MYC associated factor X
  • Synonyms
    bHLHd4, PDMCS
  • Links
    NCBI Gene ID: 4149
    neXtProt AC: NX_P61244
    UniProt: P61244

  • Chr Location
    14q23.3; chr14:65006101-65102695 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human MAX associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation die between E5.5 and 6.5 displaying a generalized developmental arrest of both embryonic and extraembryonic tissues. These defects are not associated with inappropriate apoptosis, but rather with a failure of cellsto divide.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    845
  • Tissues
    88
  • cDNA Data
    9
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059436 Ensembl Gene Model | MGI Sequence Detail 24933 C57BL/6J ±  kb
    transcript ENSMUST00000110395 Ensembl | MGI Sequence Detail 1942 Not Applicable  
    polypeptide ENSMUSP00000106025 Ensembl | MGI Sequence Detail 160 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 11
      Primer pair 5
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-12121, MGI:2144751, MGI:2144915
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 15
      Gene Ontology 17
      Phenotypes 14
    • Earliest
      J:19399 Blackwood EM, et al., Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc. Science. 1991 Mar 8;251(4998):1211-7
    • Latest
      J:345877 Suzuki A, et al., MAX controls meiotic entry in sexually undifferentiated germ cells. Sci Rep. 2024 Mar 4;14(1):5236
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory