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Mbl2 Gene Detail
Summary
  • Symbol
    Mbl2
  • Name
    mannose-binding lectin (protein C) 2
  • Synonyms
    MBL, MBL-C, MBP-C
  • Feature Type
    protein coding gene
  • IDs
    MGI:96924
    NCBI Gene: 17195
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:30210342-30217087 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 25.14 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    320 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96924
 protein coding gene Chr19:30210306-30217087 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025033
 protein coding gene Chr19:28739568-28749772 (+)
A/J MGP_AJ_G0025010
 protein coding gene Chr19:27311136-27318459 (+)
AKR/J MGP_AKRJ_G0024978
 protein coding gene Chr19:28280536-28289267 (+)
BALB/cJ MGP_BALBcJ_G0025009
 protein coding gene Chr19:27344983-27351854 (+)
C3H/HeJ MGP_C3HHeJ_G0024765
 protein coding gene Chr19:28248068-28255830 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025450
 protein coding gene Chr19:29513659-29520941 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022869
 protein coding gene Chr19:27286435-27293128 (+)
CAST/EiJ MGP_CASTEiJ_G0024235
 protein coding gene Chr19:28123480-28129805 (+)
CBA/J MGP_CBAJ_G0024743
 protein coding gene Chr19:30917536-30928567 (+)
DBA/2J MGP_DBA2J_G0024875
 protein coding gene Chr19:27257323-27263887 (+)
FVB/NJ MGP_FVBNJ_G0024837
 protein coding gene Chr19:27083997-27090629 (+)
LP/J MGP_LPJ_G0024960
 protein coding gene Chr19:28737133-28747360 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024864
 protein coding gene Chr19:30820036-30827921 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025505
 protein coding gene Chr19:28294971-28301696 (+)
PWK/PhJ MGP_PWKPhJ_G0023983
 protein coding gene Chr19:26920533-26927529 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023787
 protein coding gene Chr19:27619579-27626130 (+)
WSB/EiJ MGP_WSBEiJ_G0024302
 protein coding gene Chr19:28341413-28348839 (+)



Homology
more
  • Human Ortholog
    MBL2, mannose binding lectin 2
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MBL2, mannose binding lectin 2
  • Synonyms
    COLEC1, HSMBPC, MBL, MBL2D, MBP, MBP1, MBP-C, MBPD
  • Links
    NCBI Gene ID: 4153
    neXtProt AC: NX_P11226
    UniProt: P11226

  • Chr Location
    10q21.1; chr10:52765380-52772784 (-)  GRCh38
Human Diseases
more
  • Diseases
    61 with human MBL2 associations

Human Disease Mouse Models
      
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Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from multigenic genotypes
    66 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    47
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    710
  • Tissues
    3
  • cDNA Data
    43
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024863 Ensembl Gene Model | MGI Sequence Detail 6746 C57BL/6J ±  kb
transcript ENSMUST00000025797 Ensembl | MGI Sequence Detail 1089 Not Applicable  
polypeptide ENSMUSP00000025797 Ensembl | MGI Sequence Detail 244 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 48
    Genomic 3
    cDNA 43
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12125
References
more
  • Summaries
    All 110
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 66
  • Earliest
    J:22454 Sastry K, et al., Molecular characterization of the mouse mannose-binding proteins. The mannose-binding protein A but not C is an acute phase reactant. J Immunol. 1991 Jul 15;147(2):692-7
  • Latest
    J:354496 Stark K, et al., Antibodies and complement are key drivers of thrombosis. Immunity. 2024 Sep 10;57(9):2140-2156.e10
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory