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Mcc Gene Detail
Summary
  • Symbol
    Mcc
  • Name
    mutated in colorectal cancers
  • Synonyms
    D18Ertd451e
  • Feature Type
    protein coding gene
  • IDs
    MGI:96930
    NCBI Gene: 328949
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:44558127-44945249 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 23.74 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    12173 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96930
 protein coding gene Chr18:44558127-44945573 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024401
 protein coding gene Chr18:43166087-43575333 (-)
A/J MGP_AJ_G0024368
 protein coding gene Chr18:41621557-42013518 (-)
AKR/J MGP_AKRJ_G0024337
 protein coding gene Chr18:42795621-43193735 (-)
BALB/cJ MGP_BALBcJ_G0024368
 protein coding gene Chr18:41715147-42109261 (-)
C3H/HeJ MGP_C3HHeJ_G0024135
 protein coding gene Chr18:42822180-43237514 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024812
 protein coding gene Chr18:44660601-45069596 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022247
 protein coding gene Chr18:41413009-41789229 (-)
CAST/EiJ MGP_CASTEiJ_G0023609
 protein coding gene Chr18:42820482-43225306 (-)
CBA/J MGP_CBAJ_G0024104
 protein coding gene Chr18:45881231-46307045 (-)
DBA/2J MGP_DBA2J_G0024234
 protein coding gene Chr18:41241956-41613583 (-)
FVB/NJ MGP_FVBNJ_G0024200
 protein coding gene Chr18:40837272-41221420 (-)
LP/J MGP_LPJ_G0024318
 protein coding gene Chr18:43195975-43622470 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024231
 protein coding gene Chr18:47252471-47664613 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024859
 protein coding gene Chr18:42668307-43077841 (-)
PWK/PhJ MGP_PWKPhJ_G0023353
 protein coding gene Chr18:41429778-41814498 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023157
 protein coding gene Chr18:42809553-43286558 (-)
WSB/EiJ MGP_WSBEiJ_G0023672
 protein coding gene Chr18:42589907-42986554 (-)



Homology
more
  • Human Ortholog
    MCC, MCC regulator of WNT signaling pathway
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MCC, MCC regulator of WNT signaling pathway
  • Synonyms
    MCC1
  • Links
    NCBI Gene ID: 4163
    neXtProt AC: NX_P23508
    UniProt: P23508

  • Chr Location
    5q22.2; chr5:113022106-113488823 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human MCC associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 4 alleles in 3 genetic backgrounds
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for hypomorphic or null mutations are viable and fertile with no gross abnormalities. Conditional knockout in colonic and intestinal epithelial cells exacerbates inflammation-associated carcinogenesis in the colon. Constitutive KO affects DNA repair.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1019
  • Tissues
    102
  • cDNA Data
    9
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071856 Ensembl Gene Model | MGI Sequence Detail 387123 C57BL/6J ±  kb
    transcript ENSMUST00000089874 Ensembl | MGI Sequence Detail 7858 Not Applicable  
    polypeptide ENSMUSP00000087318 Ensembl | MGI Sequence Detail 1003 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • InterPro Domains
      IPR018247 EF-Hand 1, calcium-binding site
      IPR002048 EF-hand domain
      IPR011992 EF-hand domain pair
      IPR040171 Harmonin-binding protein USHBP1-like
      IPR019536 Harmonin-binding protein USHBP1, PDZ-binding domain
    • GlyGen
      G3UW40 3 sites, 3 N-linked glycans (3 sites)
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 1
      cDNA 9
      Primer pair 8
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12132, MGI:1196414
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 2
      Gene Ontology 2
      Phenotypes 9
    • Earliest
      J:15307 Kinzler KW, et al., Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers [see comments]. Science. 1991 Mar 15;251(4999):1366-70
    • Latest
      J:294342 Currey N, et al., Mouse Model of Mutated in Colorectal Cancer Gene Deletion Reveals Novel Pathways in Inflammation and Cancer. Cell Mol Gastroenterol Hepatol. 2019;7(4):819-839
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory