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Smcp Gene Detail
Summary
  • Symbol
    Smcp
  • Name
    sperm mitochondria-associated cysteine-rich protein
  • Synonyms
    Mcsp
  • Feature Type
    protein coding gene
  • IDs
    MGI:96945
    NCBI Gene: 17235
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:92491174-92496304 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 40.14 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    216 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96945
 protein coding gene Chr3:92491173-92496380 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027503
 protein coding gene Chr3:93030095-93035183 (-)
A/J MGP_AJ_G0027470
 protein coding gene Chr3:90105537-90110593 (-)
AKR/J MGP_AKRJ_G0027435
 protein coding gene Chr3:92219709-92224809 (-)
BALB/cJ MGP_BALBcJ_G0027478
 protein coding gene Chr3:89922672-89927782 (-)
C3H/HeJ MGP_C3HHeJ_G0027218
 protein coding gene Chr3:92439881-92444970 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027922
 protein coding gene Chr3:96576410-96581508 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025271
 protein coding gene Chr3:86741381-86746618 (-)
CAST/EiJ MGP_CASTEiJ_G0026665
 protein coding gene Chr3:91850166-91858074 (-)
CBA/J MGP_CBAJ_G0027192
 protein coding gene Chr3:99897410-99902502 (-)
DBA/2J MGP_DBA2J_G0027330
 protein coding gene Chr3:89427164-89432356 (-)
FVB/NJ MGP_FVBNJ_G0027298
 protein coding gene Chr3:87601378-87606454 (-)
LP/J MGP_LPJ_G0027438
 protein coding gene Chr3:94244570-94249716 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027323
 protein coding gene Chr3:106174805-106179922 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027981
 protein coding gene Chr3:91956723-91961891 (-)
PWK/PhJ MGP_PWKPhJ_G0026398
 protein coding gene Chr3:89310498-89316087 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026217
 protein coding gene Chr3:90282818-90287968 (-)
WSB/EiJ MGP_WSBEiJ_G0026748
 protein coding gene Chr3:92332587-92337697 (-)



Homology
more
  • Human Ortholog
    SMCP, sperm mitochondria associated cysteine rich protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SMCP, sperm mitochondria associated cysteine rich protein
  • Synonyms
    HSMCSGEN1, MCS, MCSP
  • Links
    NCBI Gene ID: 4184
    neXtProt AC: NX_P49901
    UniProt: P49901

  • Chr Location
    1q21.3; chr1:152878322-152885047 (+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
On a 129 inbred background, males homozygous for a targeted null mutation produce sperm with reduced motility and capacity to penetrate oocytes resulting in infertility. Noninbred mutant males are normally fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    10
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    1
  • cDNA Data
    83
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000074435 Ensembl Gene Model | MGI Sequence Detail 5131 C57BL/6J ±  kb
    transcript ENSMUST00000194965 Ensembl | MGI Sequence Detail 744 Not Applicable  
    polypeptide ENSMUSP00000142023 Ensembl | MGI Sequence Detail 143 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 85
      Genomic 1
      cDNA 83
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-12159
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 5
      Phenotypes 10
    • Earliest
      J:10296 Kleene KC, et al., Sequence and developmental expression of the mRNA encoding the seleno-protein of the sperm mitochondrial capsule in the mouse. Dev Biol. 1990 Feb;137(2):395-402
    • Latest
      J:302829 Lu J, et al., Mouse models for human hyperuricaemia: a critical review. Nat Rev Rheumatol. 2019 Jul;15(7):413-426
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory