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Slc3a2 Gene Detail
Summary
  • Symbol
    Slc3a2
  • Name
    solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2
  • Synonyms
    4F2HC, Cd98, Ly-10, Ly-m10, Mdu1, Mgp-2hc
  • Feature Type
    protein coding gene
  • IDs
    MGI:96955
    NCBI Gene: 17254
  • Alliance
    gene page
  • Transcription Start Sites
    29 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8684931-8700733 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 5.44 cM
  • Mapping Data
    38 experiments
Strain
Comparison
more
  • SNPs within 2kb
    407 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96955
 protein coding gene Chr19:8684246-8700733 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024803
 protein coding gene Chr19:5975067-5991625 (-)
A/J MGP_AJ_G0024771
 protein coding gene Chr19:5658969-5674908 (-)
AKR/J MGP_AKRJ_G0024746
 protein coding gene Chr19:5741029-5760961 (-)
BALB/cJ MGP_BALBcJ_G0024771
 protein coding gene Chr19:5761467-5777070 (-)
C3H/HeJ MGP_C3HHeJ_G0024537
 protein coding gene Chr19:5828814-5844251 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025218
 protein coding gene Chr19:6092958-6111947 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022647
 protein coding gene Chr19:5899742-5915452 (-)
CAST/EiJ MGP_CASTEiJ_G0024010
 protein coding gene Chr19:5475490-5492054 (-)
CBA/J MGP_CBAJ_G0024511
 protein coding gene Chr19:6206756-6224523 (-)
DBA/2J MGP_DBA2J_G0024638
 protein coding gene Chr19:5483955-5505013 (-)
FVB/NJ MGP_FVBNJ_G0024605
 protein coding gene Chr19:5565325-5580720 (-)
LP/J MGP_LPJ_G0024725
 protein coding gene Chr19:5865117-5882800 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024632
 protein coding gene Chr19:6084471-6099941 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025267
 protein coding gene Chr19:5785835-5804372 (-)
PWK/PhJ MGP_PWKPhJ_G0023755
 protein coding gene Chr19:5152683-5170727 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023560
 protein coding gene Chr19:5389112-5404088 (-)
WSB/EiJ MGP_WSBEiJ_G0024072
 protein coding gene Chr19:5753201-5769451 (-)



Homology
more
  • Human Ortholog
    SLC3A2, solute carrier family 3 member 2
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC3A2, solute carrier family 3 member 2
  • Synonyms
    4F2, 4F2HC, 4T2HC, CD98, CD98HC, MDU1, NACAE
  • Links
    NCBI Gene ID: 6520
    neXtProt AC: NX_P08195
    UniProt: P08195

  • Chr Location
    11q12.3; chr11:62856004-62888880 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human SLC3A2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    24 phenotypes from 4 alleles in 5 genetic backgrounds
    4 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice display embryonic lethality. Mice homozygous for a conditional allele activated in the intestinal epithelia exhibit resistance to decreased susceptibility to induced colitis and colitis-associated cancer.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    83
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1055
  • Tissues
    66
  • cDNA Data
    379
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17254 NCBI Gene Model | MGI Sequence Detail 15803 C57BL/6J ±  kb
    transcript NM_001161413 RefSeq | MGI Sequence Detail 2128 C57BL/6  
    polypeptide P10852 UniProt | EBI | MGI Sequence Detail 526 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000001851 amino acid transporter heavy chain SLC3A2
      (term hierarchy)
    • PDB
      6I9Q, 6SUA
    • InterPro Domains
      IPR042280 Amino acid transporter heavy chain SLC3A2
      IPR017853 Glycoside hydrolase superfamily
      IPR013780 Glycosyl hydrolase, all-beta
      IPR006047 Glycosyl hydrolase, family 13, catalytic domain
      IPR031984 Solute carrier family 3 member 2, N-terminal domain
    • GlyGen
      P10852 9 sites, 11 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 383
      cDNA 379
      Primer pair 3
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11948, MGD-MRK-12009, MGD-MRK-12016, MGD-MRK-12179, MGD-MRK-12223, MGD-MRK-35053, MGI:106597, MGI:2147500
    References
    more
    • Summaries
      All 111
      Developmental Gene Expression 9
      Gene Ontology 13
      Phenotypes 32
    • Earliest
      J:4451 Kimura S, et al., A new lymphocyte alloantigen (Ly-10) controlled by a gene linked to the Lyt-1 locus. Immunogenetics. 1980;10(4):363-72
    • Latest
      J:346995 Huang N, et al., Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation. Nat Commun. 2024 Mar 22;15(1):2598
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory