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Mep1b Gene Detail
Summary
  • Symbol
    Mep1b
  • Name
    meprin 1 beta
  • Synonyms
    Mep-1b, meprin beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:96964
    NCBI Gene: 17288
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:21205401-21233256 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 11.81 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    753 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96964
 protein coding gene Chr18:21194980-21233256 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024187
 protein coding gene Chr18:18698904-18726703 (+)
A/J MGP_AJ_G0024151
 protein coding gene Chr18:18199882-18227919 (+)
AKR/J MGP_AKRJ_G0024120
 protein coding gene Chr18:18763591-18791164 (+)
BALB/cJ MGP_BALBcJ_G0024151
 protein coding gene Chr18:18260477-18288175 (+)
C3H/HeJ MGP_C3HHeJ_G0023919
 protein coding gene Chr18:18704011-18733127 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024593
 protein coding gene Chr18:19589680-19617819 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022035
 protein coding gene Chr18:17318189-17346806 (+)
CAST/EiJ MGP_CASTEiJ_G0023392
 protein coding gene Chr18:18482412-18513322 (+)
CBA/J MGP_CBAJ_G0023887
 protein coding gene Chr18:20093758-20129319 (+)
DBA/2J MGP_DBA2J_G0024019
 protein coding gene Chr18:17907646-17935991 (+)
FVB/NJ MGP_FVBNJ_G0023985
 protein coding gene Chr18:17688270-17716416 (+)
LP/J MGP_LPJ_G0024100
 protein coding gene Chr18:18858079-18885814 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024013
 protein coding gene Chr18:20975599-21007607 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024641
 protein coding gene Chr18:18533736-18563685 (+)
PWK/PhJ MGP_PWKPhJ_G0023137
 protein coding gene Chr18:18014076-18042795 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022946
 protein coding gene Chr18:18721916-18754338 (+)
WSB/EiJ MGP_WSBEiJ_G0023457
 protein coding gene Chr18:18451188-18480780 (+)



Homology
more
  • Human Ortholog
    MEP1B, meprin A subunit beta
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MEP1B, meprin A subunit beta
  • Links
    NCBI Gene ID: 4225
    neXtProt AC: NX_Q16820
    UniProt: Q16820

  • Chr Location
    18q12.1; chr18:32185069-32220404 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 4 genetic backgrounds
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit 50% prenatal lethality; survivors have reduced birth weight and show altered renal gene expression, but otherwise are apparently normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    12
  • cDNA Data
    41
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17288 NCBI Gene Model | MGI Sequence Detail 27856 C57BL/6J ±  kb
    transcript NM_008586 RefSeq | MGI Sequence Detail 2286 Not Specified  
    polypeptide Q61847 UniProt | EBI | MGI Sequence Detail 704 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 45
      Genomic 1
      cDNA 44

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-12195, MGD-MRK-12198
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 1
      Gene Ontology 8
      Phenotypes 32
    • Earliest
      J:17708 Gorbea CM, et al., Homo- and heterotetrameric forms of the membrane-bound metalloendopeptidases meprin A and B. Arch Biochem Biophys. 1991 Nov 1;290(2):549-53
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory