Clec10a MGI Mouse Gene Detail - MGI:96975 - C-type lectin domain family 10, member A

Symbol

Clec10a
Name

C-type lectin domain family 10, member A
Synonyms

CD301a, Mgl1

Feature Type

protein coding gene
IDs

MGI:96975
NCBI Gene: 17312
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr11:70057449-70061662 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 42.99 cM
Mapping Data

3 experiments

SNPs within 2kb

87 from dbSNP Build 142
Strain Annotations

15
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96975	protein coding gene	Chr11:70047023-70061662 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018583	protein coding gene	Chr11:70675868-70685635 (+)
A/J	MGP_AJ_G0018551	protein coding gene	Chr11:67992607-67998085 (+)
AKR/J	MGP_AKRJ_G0018520	protein coding gene	Chr11:70027151-70033138 (+)
BALB/cJ	MGP_BALBcJ_G0018523	protein coding gene	Chr11:68320165-68324516 (+)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0018974	protein coding gene	Chr11:72758124-72789445 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016619	protein coding gene	Chr11:64915420-64921817 (+)
CAST/EiJ	MGP_CASTEiJ_G0017891	protein coding gene	Chr11:70283436-70315525 (+)
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0018418	protein coding gene	Chr11:67573403-67578621 (+)
FVB/NJ	MGP_FVBNJ_G0018408	protein coding gene	Chr11:67227544-67231925 (+)
LP/J	MGP_LPJ_G0018488	protein coding gene	Chr11:71249992-71253864 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0019016	protein coding gene	Chr11:70296455-70300103 (+)
PWK/PhJ	MGP_PWKPhJ_G0017665	protein coding gene	Chr11:68202121-68231318 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017455	protein coding gene	Chr11:70092599-70097035 (+)
WSB/EiJ	MGP_WSBEiJ_G0017945	protein coding gene	Chr11:69960071-69964610 (+)

Human Ortholog

CLEC10A, C-type lectin domain containing 10A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CLEC10A, C-type lectin domain containing 10A
Synonyms

CD301, CLECSF13, CLECSF14, HML, HML2, MGL
Links

HGNC:16916

NCBI Gene ID: 10462

neXtProt AC: NX_Q8IUN9

UniProt: Q8IUN9
Chr Location

17p13.1; chr17:7074537-7080307 (-) GRCh38

MGI Vertebrate Homology

Clec10a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CLEC10A
Gene Tree

Clec10a

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
1 phenotype from multigenic genotypes
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Endonuclease-mediated

5
Spontaneous

1
Targeted

5
Transgenic

1
Genomic Mutations

3 involving Clec10a
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit elevated red blood cell counts but appear to be otherwise normal. Homozygosity for the p.Q236* mutation affects cell surface expression and leads to hypersensitivity to house dust mites.

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All GO Annotations

9
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

754
Tissues

41
cDNA Data

26
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase clec10a

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All Sequences

53
RefSeq

4
UniProt

8
CCDS

CCDS24936.1, CCDS56784.1

Ensembl

ENSMUSG00000000318 (Evidence)
NCBI Gene

17312

			Length	Strain/Species	Flank
genomic	17312	NCBI Gene Model \| MGI Sequence Detail	4214	C57BL/6J	± kb
transcript	NM_001204252	RefSeq \| MGI Sequence Detail	1501	ZRU/MplStud
polypeptide	P49300	UniProt \| EBI \| MGI Sequence Detail	304	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000001410 C-type lectin domain family 10 member A

(term hierarchy)
InterPro Domains

IPR033989 CD209-like, C-type lectin-like domain

IPR050111 C-type lectin and snaclec domain-containing protein

IPR018378 C-type lectin, conserved site

IPR016187 C-type lectin fold

IPR001304 C-type lectin-like

IPR016186 C-type lectin-like/link domain superfamily

IPR051379 C-type Lectin Receptor Immune Modulators
GlyGen

P49300 2 sites

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All nucleic 28

cDNA 27

Primer pair 1

Microarray probesets 3

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MGD-MRK-12220

Summaries

All 63

Developmental Gene Expression 3

Gene Ontology 4

Phenotypes 31
Earliest

J:5439 Bannerman RM, et al., Hereditary disorders of the red cell in animals. Prog Hematol. 1973;8:131-79
Latest

J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Clec10a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102659	Chr11:70057474-70057489 (+)	33 bp
Tssr102660	Chr11:70057522-70057533 (+)	79 bp
Tssr102661	Chr11:70057592-70057610 (+)	152 bp
Tssr102662	Chr11:70058010-70058024 (+)	568 bp
Tssr102663	Chr11:70058028-70058048 (+)	589 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24