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Mgmt Gene Detail
Summary
  • Symbol
    Mgmt
  • Name
    O-6-methylguanine-DNA methyltransferase
  • Synonyms
    Agat, AGT
  • Feature Type
    protein coding gene
  • IDs
    MGI:96977
    NCBI Gene: 17314
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:136496343-136731995 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 82.07 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6726 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96977
 protein coding gene Chr7:136496315-136732001 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033137
 protein coding gene Chr7:141815322-142055169 (+)
A/J MGP_AJ_G0033119
 protein coding gene Chr7:137842362-138077419 (+)
AKR/J MGP_AKRJ_G0033051
 protein coding gene Chr7:141550797-141786077 (+)
BALB/cJ MGP_BALBcJ_G0033120
 protein coding gene Chr7:137588853-137823448 (+)
C3H/HeJ MGP_C3HHeJ_G0032834
 protein coding gene Chr7:141398826-141634148 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033631
 protein coding gene Chr7:147135905-147372908 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030604
 protein coding gene Chr7:139041353-139274000 (+)
CAST/EiJ MGP_CASTEiJ_G0032164
 protein coding gene Chr7:133567782-133811460 (+)
CBA/J MGP_CBAJ_G0032807
 protein coding gene Chr7:152089529-152325995 (+)
DBA/2J MGP_DBA2J_G0032959
 protein coding gene Chr7:135832865-136067195 (+)
FVB/NJ MGP_FVBNJ_G0032912
 protein coding gene Chr7:135687029-135925118 (+)
LP/J MGP_LPJ_G0033053
 protein coding gene Chr7:143355960-143590637 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032944
 protein coding gene Chr7:152879653-153120258 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033651
 protein coding gene Chr7:140575762-140812302 (+)
PWK/PhJ MGP_PWKPhJ_G0031870
 protein coding gene Chr7:128975107-129213522 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031715
 protein coding gene Chr7:127323961-127566829 (+)
WSB/EiJ MGP_WSBEiJ_G0032275
 protein coding gene Chr7:141459129-141697742 (+)



Homology
more
  • Human Ortholog
    MGMT, O-6-methylguanine-DNA methyltransferase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MGMT, O-6-methylguanine-DNA methyltransferase
  • Links
    NCBI Gene ID: 4255
    neXtProt AC: NX_P16455
    UniProt: P16455

  • Chr Location
    10q26.3; chr10:129467190-129770983 (+)  GRCh38
Human Diseases
more
  • Diseases
    12 with human MGMT associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for targeted knock-out mutations of this gene display increased sensitivity to various alkylating agents.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    4
  • cDNA Data
    21
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000054612 Ensembl Gene Model | MGI Sequence Detail 235653 C57BL/6J ±  kb
    transcript ENSMUST00000081510 Ensembl | MGI Sequence Detail 2894 Not Applicable  
    polypeptide ENSMUSP00000080224 Ensembl | MGI Sequence Detail 211 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000010388 methylated-DNA--protein-cysteine methyltransferase
      (term hierarchy)
    • EC
      2.1.1.63
    • InterPro Domains
      IPR036217 Methylated DNA-protein cysteine methyltransferase, DNA binding domain
      IPR036631 Methylated DNA-protein cysteine methyltransferase domain superfamily
      IPR001497 Methylated-DNA-[protein]-cysteine S-methyltransferase, active site
      IPR014048 Methylated-DNA-[protein]-cysteine S-methyltransferase, DNA binding
      IPR008332 Methylguanine DNA methyltransferase, ribonuclease-like domain
      IPR036388 Winged helix-like DNA-binding domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 6
      cDNA 21

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-1181, MGD-MRK-12222, MGI:2141895, MGI:87956
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 1
      Gene Ontology 11
      Phenotypes 33
    • Earliest
      J:519 Rouleau J, et al., The mouse DNA methyltransferase 5'-region. A unique housekeeping gene promoter. J Biol Chem. 1992 Apr 15;267(11):7368-77
    • Latest
      J:351214 Benjaskulluecha S, et al., O(6)-methylguanine DNA methyltransferase regulates beta-glucan-induced trained immunity of macrophages via farnesoid X receptor and AMPK. iScience. 2024 Jan 19;27(1):108733
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory