Mmp2 MGI Mouse Gene Detail - MGI:97009 - matrix metallopeptidase 2

Symbol

Mmp2
Name

matrix metallopeptidase 2
Synonyms

72kDa gelatinase, 72kDa type IV collagenase, Clg4a, GelA, gelatinase A, MMP-2

Feature Type

protein coding gene
IDs

MGI:97009
NCBI Gene: 17390
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr8:93553920-93580049 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 44.99 cM
Mapping Data

4 experiments

SNPs within 2kb

833 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97009	protein coding gene	Chr8:93553919-93580049 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033936	protein coding gene	Chr8:94142333-94170213 (+)
A/J	MGP_AJ_G0033919	protein coding gene	Chr8:90430669-90456397 (+)
AKR/J	MGP_AKRJ_G0033845	protein coding gene	Chr8:92973187-92999586 (+)
BALB/cJ	MGP_BALBcJ_G0033911	protein coding gene	Chr8:90585431-90611787 (+)
C3H/HeJ	MGP_C3HHeJ_G0033621	protein coding gene	Chr8:93688247-93714915 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034432	protein coding gene	Chr8:97609424-97637355 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031373	protein coding gene	Chr8:84354184-84384521 (+)
CAST/EiJ	MGP_CASTEiJ_G0032953	protein coding gene	Chr8:93245083-93273704 (+)
CBA/J	MGP_CBAJ_G0033597	protein coding gene	Chr8:100852692-100884038 (+)
DBA/2J	MGP_DBA2J_G0033751	protein coding gene	Chr8:89974556-90001366 (+)
FVB/NJ	MGP_FVBNJ_G0033698	protein coding gene	Chr8:88914194-88940563 (+)
LP/J	MGP_LPJ_G0033843	protein coding gene	Chr8:94256075-94290857 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033740	protein coding gene	Chr8:103212607-103237412 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034450	protein coding gene	Chr8:93089605-93116905 (+)
PWK/PhJ	MGP_PWKPhJ_G0032655	protein coding gene	Chr8:89325032-89351636 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032492	protein coding gene	Chr8:91938960-91966060 (+)
WSB/EiJ	MGP_WSBEiJ_G0033065	protein coding gene	Chr8:93551082-93577894 (+)

Human Ortholog

MMP2, matrix metallopeptidase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MMP2, matrix metallopeptidase 2
Synonyms

CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1
Links

HGNC:7166

NCBI Gene ID: 4313

neXtProt AC: NX_P08253

UniProt: P08253
Chr Location

16q12.2; chr16:55389700-55506691 (+) GRCh38

MGI Vertebrate Homology

Mmp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MMP2
Protein SuperFamily

Peptidase_M10A_matrix
Gene Tree

Mmp2

Diseases

11 with human MMP2 associations

				Human Disease	Mouse Models
				arteriosclerosis IDs arteriosclerosis DOID:2349 ICD10CM:I70 MESH:D001161 NCI:C34398 UMLS_CUI:C0003850
				carotid artery disease IDs carotid artery disease DOID:3407 MESH:D002340 NCI:C84476 UMLS_CUI:C0007273
				diabetic retinopathy IDs diabetic retinopathy DOID:8947 ICD9CM:362.0 MESH:D003930 NCI:C34538 UMLS_CUI:C0011884
				hypertension IDs hypertension DOID:10763 EFO:0000537 ICD10CM:I10 ICD9CM:401-405.99 ICD9CM:997.91 MESH:D006973 NCI:C3117 UMLS_CUI:C0020538
				intracranial aneurysm IDs intracranial aneurysm DOID:10941 EFO:0003870 MESH:D002532 NCI:C34458 UMLS_CUI:C0007766
				macular degeneration IDs macular degeneration DOID:4448 MESH:D008268 NCI:C123330 ORDO:279 UMLS_CUI:C0024437
				myopia IDs myopia DOID:11830 ICD10CM:H52.1 ICD9CM:367.1 MESH:D009216 NCI:C102533 OMIM:160700 OMIM:255500 OMIM:300613 OMIM:310460 OMIM:603221 OMIM:608367 OMIM:608474 OMIM:608908 OMIM:609256 OMIM:609257 OMIM:609258 OMIM:609259 OMIM:609994 OMIM:609995 OMIM:610320 OMIM:612554 OMIM:612717 OMIM:613959 OMIM:613969 OMIM:614166 OMIM:614167 OMIM:615420 OMIM:615431 OMIM:615946 UMLS_CUI:C0027092
				pseudoxanthoma elasticum IDs pseudoxanthoma elasticum DOID:2738 MESH:D011561 NCI:C85036 OMIM:177850 OMIM:264800 ORDO:758 UMLS_CUI:C0033847
				pterygium IDs pterygium DOID:0002116 ICD9CM:372.4 ICD9CM:372.40 UMLS_CUI:C0033999
				retinal vein occlusion IDs retinal vein occlusion DOID:1727 MESH:D012170 NCI:C34981 UMLS_CUI:C0035328
				temporal arteritis IDs temporal arteritis DOID:13375 ICD9CM:446.5 MESH:D013700 NCI:C35065 OMIM:187360 ORDO:397 UMLS_CUI:C0039483

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

58 phenotypes from 2 alleles in 6 genetic backgrounds
19 phenotypes from multigenic genotypes
1 images
139 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

3
Targeted

1
Incidental Mutations

APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit slightly delayed growth, reduced neovascularization, retarded tumor progression, an exaggerated asthma response to allergens, and impaired branching morphogenesis of the mammary gland.

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All GO Annotations

94
GO References

19

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1011
Tissues

177
cDNA Data

174
Literature Summary

122

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MMP2

Xenbase mmp2

ZFIN mmp2

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All Sequences

103
RefSeq

4
UniProt

4
CCDS

CCDS22523.1

Ensembl

ENSMUSG00000031740 (Evidence)
NCBI Gene

17390

			Length	Strain/Species	Flank
genomic	17390	NCBI Gene Model \| MGI Sequence Detail	26130	C57BL/6J	± kb
transcript	NM_008610	RefSeq \| MGI Sequence Detail	3078	ZRU/MplStud
polypeptide	P33434	UniProt \| EBI \| MGI Sequence Detail	662	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010479 72 kDa type IV collagenase

(term hierarchy)
EC

3.4.24.24
InterPro Domains

IPR000562 Fibronectin type II domain

IPR036943 Fibronectin type II domain superfamily

IPR018486 Hemopexin, conserved site

IPR000585 Hemopexin-like domain

IPR036375 Hemopexin-like domain superfamily

IPR018487 Hemopexin-like repeats

IPR013806 Kringle-like fold

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR021190 Peptidase M10A

IPR033739 Peptidase M10A, catalytic domain

IPR021158 Peptidase M10A, cysteine switch, zinc binding site

IPR001818 Peptidase M10, metallopeptidase

IPR006026 Peptidase, metallopeptidase

IPR036365 PGBD-like superfamily
GlyGen

P33434 2 sites

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All nucleic 198

cDNA 174

Primer pair 17

Other 7

Microarray probesets 3

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MGD-MRK-12279, MGD-MRK-2013

Summaries

All 408

Developmental Gene Expression 122

Gene Ontology 19

Phenotypes 139
Earliest

J:218 Bennett D, Brain hernia, a new recessive mutation in the mouse. J Hered. 1959;50(6):265-8
Latest

J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584

TSS for Mmp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78752	Chr8:93552885-93552902 (+)	-1,026 bp
Tssr78753	Chr8:93553901-93554023 (+)	42 bp
Tssr78754	Chr8:93554024-93554057 (+)	121 bp
Tssr78755	Chr8:93554062-93554067 (+)	145 bp
Tssr78756	Chr8:93554076-93554085 (+)	161 bp
Tssr78757	Chr8:93557392-93557435 (+)	3,494 bp
Tssr78758	Chr8:93566790-93566803 (+)	12,877 bp
Tssr78759	Chr8:93566851-93566863 (+)	12,937 bp
Tssr78760	Chr8:93567060-93567085 (+)	13,153 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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