Me1 MGI Mouse Gene Detail - MGI:97043 - malic enzyme 1, NADP(+)-dependent, cytosolic

Symbol

Me1
Name

malic enzyme 1, NADP(+)-dependent, cytosolic
Synonyms

D9Ertd267e, Mdh-1, Mod-1, Mod1

Feature Type

protein coding gene
IDs

MGI:97043
NCBI Gene: 17436
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr9:86463416-86577967 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 46.58 cM
Mapping Data

149 experiments

SNPs within 2kb

3530 from dbSNP Build 142
Strain Annotations

18
PCR

4
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97043	protein coding gene	Chr9:86463416-86578006 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0035098	protein coding gene	Chr9:87412182-87541982 (-)
A/J	MGP_AJ_G0035079	protein coding gene	Chr9:84366205-84484083 (-)
AKR/J	MGP_AKRJ_G0035007	protein coding gene	Chr9:86360979-86493084 (-)
BALB/cJ	MGP_BALBcJ_G0035067	protein coding gene	Chr9:84005804-84127254 (-)
C3H/HeJ	MGP_C3HHeJ_G0034779	protein coding gene	Chr9:86823772-86952771 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0035591	protein coding gene	Chr9:89768088-89904185 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0032498	protein coding gene	Chr9:83126895-83256223 (-)
CAST/EiJ	MGP_CASTEiJ_G0034097	protein coding gene	Chr9:87296694-87418312 (-)
CBA/J	MGP_CBAJ_G0034752	protein coding gene	Chr9:92957449-93070322 (-)
DBA/2J	MGP_DBA2J_G0034910	protein coding gene	Chr9:83924213-84042740 (-)
FVB/NJ	MGP_FVBNJ_G0034853	protein coding gene	Chr9:83013903-83127615 (-)
LP/J	MGP_LPJ_G0034991	protein coding gene	Chr9:87625233-87753293 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034895	protein coding gene	Chr9:94547503-94682601 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0035611	protein coding gene	Chr9:86472015-86598073 (-)
PWK/PhJ	MGP_PWKPhJ_G0033801	protein coding gene	Chr9:84091462-84209680 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0033637	protein coding gene	Chr9:86677760-86794517 (-)
WSB/EiJ	MGP_WSBEiJ_G0034214	protein coding gene	Chr9:86505683-86634324 (-)

Human Ortholog

ME1, malic enzyme 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ME1, malic enzyme 1
Synonyms

HUMNDME, MES
Links

HGNC:6983

NCBI Gene ID: 4199

neXtProt AC: NX_P48163

UniProt: P48163
Chr Location

6q14.2; chr6:83210402-83431051 (-) GRCh38

MGI Vertebrate Homology

Me1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ME1
Protein SuperFamily

ME
Gene Tree

Me1

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Phenotype Summary

8 phenotypes from 2 alleles in 3 genetic backgrounds
18 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

14
Chemically induced (other)

1
Endonuclease-mediated

6
Gene trapped

3
Spontaneous

1
Targeted

3
Genomic Mutations

1 involving Me1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

28 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a spontaneous allele exhibit decreased body weight on a medium fat diet, altered cytoplasmic malic enzyme activity, and a male-specific reduction in food intake on a high fat diet.

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All GO Annotations

41
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

887
Tissues

133
cDNA Data

182
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase me1

ZFIN me1

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All Sequences

63
RefSeq

6
UniProt

6
CCDS

CCDS23383.1, CCDS81047.1

Ensembl

ENSMUSG00000032418 (Evidence)
NCBI Gene

17436

			Length	Strain/Species	Flank
genomic	17436	NCBI Gene Model \| MGI Sequence Detail	114552	C57BL/6J	± kb
transcript	NM_001198933	RefSeq \| MGI Sequence Detail	3335	ZRU/MplStud
polypeptide	P06801	UniProt \| EBI \| MGI Sequence Detail	572	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000010273 NADP-dependent malic enzyme

(term hierarchy)
EC

1.1.1.39, 1.1.1.40
InterPro Domains

IPR046346 Aminoacid dehydrogenase-like, N-terminal domain superfamily

IPR015884 Malic enzyme, conserved site

IPR012302 Malic enzyme, NAD-binding

IPR012301 Malic enzyme, N-terminal domain

IPR037062 Malic enzyme, N-terminal domain superfamily

IPR001891 Malic oxidoreductase

IPR036291 NAD(P)-binding domain superfamily
GlyGen

P06801 1 site, 1 O-linked glycan (1 site)

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All nucleic 188

cDNA 182

Primer pair 5

Other 1

Microarray probesets 5

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MGD-MRK-12164, MGD-MRK-12341, MGD-MRK-12345, MGI:1098755

Summaries

All 182

Developmental Gene Expression 7

Gene Ontology 11

Phenotypes 18
Earliest

J:20246 Henderson NS, Isozymes and genetic control of NADP-malate dehydrogenase in mice. Arch Biochem Biophys. 1966 Oct;117(1):28-33
Latest

J:351089 Alektiar JM, et al., Malic enzyme 1 knockout has no deleterious phenotype and is favored in the male germline under standard laboratory conditions. PLoS One. 2024;19(6):e0303577

TSS for Me1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr90790	Chr9:86577950-86578011 (-)	-14 bp
Tssr90789	Chr9:86577891-86577907 (-)	68 bp
Tssr90788	Chr9:86577824-86577842 (-)	134 bp
Tssr90787	Chr9:86577723-86577731 (-)	240 bp
Tssr90786	Chr9:86577693-86577709 (-)	266 bp
Tssr90785	Chr9:86469666-86469672 (-)	108,298 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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