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Mos Gene Detail
Summary
  • Symbol
    Mos
  • Name
    Moloney sarcoma oncogene
  • Synonyms
    c-mos
  • Feature Type
    protein coding gene
  • IDs
    MGI:97052
    NCBI Gene: 17451
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr4:3870658-3872105 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 2.16 cM, cytoband A1-A2
  • Mapping Data
    39 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97052
 protein coding gene Chr4:3870657-3872105 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028025
 protein coding gene Chr4:360335-361783 (-)
A/J MGP_AJ_G0027983
 protein coding gene Chr4:428473-429921 (-)
AKR/J MGP_AKRJ_G0027949
 protein coding gene Chr4:370048-371496 (-)
BALB/cJ MGP_BALBcJ_G0027995
 protein coding gene Chr4:401217-402665 (-)
C3H/HeJ MGP_C3HHeJ_G0027725
 protein coding gene Chr4:531712-533160 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028438
 protein coding gene Chr4:511883-513331 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025782
 protein coding gene Chr4:364679-366133 (-)
CAST/EiJ MGP_CASTEiJ_G0027178
 protein coding gene Chr4:439146-440600 (-)
CBA/J MGP_CBAJ_G0027700
 protein coding gene Chr4:376916-378364 (-)
DBA/2J MGP_DBA2J_G0027840
 protein coding gene Chr4:399441-400889 (-)
FVB/NJ MGP_FVBNJ_G0027807
 protein coding gene Chr4:328865-330313 (-)
LP/J MGP_LPJ_G0027951
 protein coding gene Chr4:407405-408853 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027840
 protein coding gene Chr4:570704-572152 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028497
 protein coding gene Chr4:367599-369047 (-)
PWK/PhJ MGP_PWKPhJ_G0026900
 protein coding gene Chr4:458838-460295 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026730
 protein coding gene Chr4:385644-387096 (-)
WSB/EiJ MGP_WSBEiJ_G0027258
 protein coding gene Chr4:512840-514287 (-)



Homology
more
  • Human Ortholog
    MOS, MOS proto-oncogene, serine/threonine kinase
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MOS, MOS proto-oncogene, serine/threonine kinase
  • Synonyms
    MSV, OZEMA20
  • Links
    NCBI Gene ID: 4342
    neXtProt AC: NX_P00540
    UniProt: P00540

  • Chr Location
    8q12.1; chr8:56112942-56113982 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 4 alleles in 4 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations that inactivate the gene result in female infertility and an increased susceptibility to tumors. Oocytes progress through meiosis II without arrest and undergo spontaneous parthenogenetic activation. Male mice are fertile and show no spermatogenic defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    26
  • cDNA Data
    10
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17451 NCBI Gene Model | MGI Sequence Detail 1448 C57BL/6J ±  kb
    transcript NM_020021 RefSeq | MGI Sequence Detail 1448 ZRU/MplStud  
    polypeptide P00536 UniProt | EBI | MGI Sequence Detail 343 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 39
      Genomic 21
      cDNA 11
      Primer pair 5
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-12357
    References
    more
    • Summaries
      All 128
      Developmental Gene Expression 14
      Gene Ontology 14
      Phenotypes 24
    • Earliest
      J:6268 Oskarsson M, et al., Properties of a normal mouse cell DNA sequence (sarc) homologous to the src sequence of Moloney sarcoma virus. Science. 1980 Mar 14;207(4436):1222-4
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory