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Mt2 Gene Detail
Summary
  • Symbol
    Mt2
  • Name
    metallothionein 2
  • Synonyms
    Mt-2, MT-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:97172
    NCBI Gene: 17750
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:94899292-94900196 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 46.32 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    4
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97172
 protein coding gene Chr8:94899246-94900196 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033956
 protein coding gene Chr8:95574416-95575365 (+)
A/J MGP_AJ_G0033939
 protein coding gene Chr8:91854956-91855905 (+)
AKR/J MGP_AKRJ_G0033865
 protein coding gene Chr8:94375029-94375978 (+)
BALB/cJ MGP_BALBcJ_G0033931
 protein coding gene Chr8:91945113-91946062 (+)
C3H/HeJ MGP_C3HHeJ_G0033641
 protein coding gene Chr8:95076774-95077723 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034452
 protein coding gene Chr8:99069642-99070591 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031393
 protein coding gene Chr8:85662010-85662957 (+)
CAST/EiJ MGP_CASTEiJ_G0032973
 protein coding gene Chr8:94668233-94669182 (+)
CBA/J MGP_CBAJ_G0033617
 protein coding gene Chr8:102359221-102360170 (+)
DBA/2J MGP_DBA2J_G0033771
 protein coding gene Chr8:91324898-91325847 (+)
FVB/NJ MGP_FVBNJ_G0033718
 protein coding gene Chr8:90290897-90291846 (+)
LP/J MGP_LPJ_G0033863
 protein coding gene Chr8:95725833-95726782 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033760
 protein coding gene Chr8:104659150-104660099 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034470
 protein coding gene Chr8:94531982-94532931 (+)
PWK/PhJ MGP_PWKPhJ_G0032675
 protein coding gene Chr8:90688202-90689138 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032512
 protein coding gene Chr8:93357658-93358607 (+)
WSB/EiJ MGP_WSBEiJ_G0033085
 protein coding gene Chr8:95050402-95051351 (+)



Homology
more
  • Human Ortholog
    MT1A, metallothionein 1A
  • Vertebrate Orthologs
    12
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MT1A, metallothionein 1A
  • Synonyms
    MT1, MT-1A, MT1S, MTC, MT-IA
  • Links
    NCBI Gene ID: 4489
    neXtProt AC: NX_P04731
    UniProt: P04731

  • Chr Location
    16q13; chr16:56638666-56640087 (+)  GRCh38
  • Human Ortholog
    MT1B, metallothionein 1B
  • Synonyms
    MT1, MT-1B, MT1Q, MT-IB, MTP
  • Links
    NCBI Gene ID: 4490
    neXtProt AC: NX_P07438
    UniProt: P07438

  • Chr Location
    16q13; chr16:56651886-56653204 (+)  GRCh38
  • Human Ortholog
    MT1E, metallothionein 1E
  • Synonyms
    MT1, MT-1E, MTD, MT-IE
  • Links
    NCBI Gene ID: 4493
    neXtProt AC: NX_P04732
    UniProt: P04732

  • Chr Location
    16q13; chr16:56625475-56627112 (+)  GRCh38
  • Human Ortholog
    MT1F, metallothionein 1F
  • Synonyms
    MT1
  • Links
    NCBI Gene ID: 4494
    neXtProt AC: NX_P04733
    UniProt: P04733

  • Chr Location
    16q13; chr16:56657731-56660698 (+)  GRCh38
  • Human Ortholog
    MT1G, metallothionein 1G
  • Synonyms
    MT1, MT1K
  • Links
    NCBI Gene ID: 4495
    neXtProt AC: NX_P13640
    UniProt: P13640

  • Chr Location
    16q13; chr16:56666730-56668065 (-)  GRCh38
  • Human Ortholog
    MT1H, metallothionein 1H
  • Synonyms
    MT-0, MT1, MT-1H, MT-IH
  • Links
    NCBI Gene ID: 4496
    neXtProt AC: NX_P80294
    UniProt: P80294

  • Chr Location
    16q13; chr16:56669814-56671129 (+)  GRCh38
  • Human Ortholog
    MT1L, metallothionein 1L (pseudogene)
  • Synonyms
    MT1, MT1LP, MT1R, MTF
  • Links
    NCBI Gene ID: 4500

  • Chr Location
    16q13; chr16:56617461-56618818 (+)  GRCh38
  • Human Ortholog
    MT1X, metallothionein 1X
  • Synonyms
    MT1, MT-1l
  • Links
    NCBI Gene ID: 4501
    neXtProt AC: NX_P80297
    UniProt: P80297

  • Chr Location
    16q13; chr16:56682470-56684196 (+)  GRCh38
  • Human Ortholog
    MT2A, metallothionein 2A
  • Synonyms
    MT-2, MT2, MT-II
  • Links
    NCBI Gene ID: 4502
    neXtProt AC: NX_P02795
    UniProt: P02795

  • Chr Location
    16q13; chr16:56608584-56609497 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human MT2A associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    88 phenotypes from multigenic genotypes
    136 phenotype references
Mice homozygous for null alleles of Mt1 and Mt2 exhibit increased sensitivity to xenobiotics and injury with decreased wound healing and abnormal mineral aborption.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    30
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    52
  • cDNA Data
    166
  • Literature Summary
    19
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031762 Ensembl Gene Model | MGI Sequence Detail 905 C57BL/6J ±  kb
transcript ENSMUST00000212806 Ensembl | MGI Sequence Detail 388 Not Applicable  
polypeptide ENSMUSP00000148308 Ensembl | MGI Sequence Detail 76 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR017854 Metallothionein domain superfamily
    IPR023587 Metallothionein domain superfamily, vertebrate
    IPR000006 Metallothionein, vertebrate
    IPR018064 Metallothionein, vertebrate, metal binding site
Molecular
Reagents
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  • All nucleic 180
    Genomic 5
    cDNA 166
    Primer pair 7
    Other 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12574, MGD-MRK-12577, MGI:2142416
References
more
  • Summaries
    All 213
    Developmental Gene Expression 19
    Gene Ontology 7
    Phenotypes 136
  • Earliest
    J:7659 Searle PF, et al., Regulation, linkage, and sequence of mouse metallothionein I and II genes. Mol Cell Biol. 1984 Jul;4(7):1221-30
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory