Mx1 MGI Mouse Pseudogene Detail - MGI:97243

Symbol

Mx1
Name

MX dynamin-like GTPase 1
Synonyms

Mx, Mx-1, myxovirus (influenza) resistance 1 polypeptide

Feature Type

polymorphic pseudogene

BioType Conflict
IDs

MGI:97243
NCBI Gene: 17857
Alliance

gene page
Transcription Start Sites

15 TSS

Sequence Map

Chr16:97248235-97264106 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 57.46 cM, cytoband C4
Mapping Data

40 experiments

SNPs within 2kb

485 from dbSNP Build 142
Strain Annotations

18
PCR

2
RFLP

18

Strain-Specific Marker

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97243	polymorphic pseudogene	Chr16:97248235-97264107 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0023090	protein coding gene	Chr16:98874926-98894553 (-)
A/J	MGP_AJ_G0023058	protein coding gene	Chr16:94209533-94226985 (-)
AKR/J	MGP_AKRJ_G0023028	protein coding gene	Chr16:97107100-97125730 (-)
BALB/cJ	MGP_BALBcJ_G0023060	protein coding gene	Chr16:94763282-94780694 (-)
C3H/HeJ	MGP_C3HHeJ_G0022821	protein coding gene	Chr16:97638155-97654201 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0023507	protein coding gene	Chr16:101977529-101993053 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0021009	protein coding gene	Chr16:92038983-92063241 (-)
CAST/EiJ	MGP_CASTEiJ_G0022341	protein coding gene	Chr16:98437260-98463749 (-)
CBA/J	MGP_CBAJ_G0022790	protein coding gene	Chr16:106397953-106422648 (-)
DBA/2J	MGP_DBA2J_G0022924	protein coding gene	Chr16:94074664-94093083 (-)
FVB/NJ	MGP_FVBNJ_G0022898	protein coding gene	Chr16:93240557-93256003 (-)
LP/J	MGP_LPJ_G0022994	protein coding gene	Chr16:98530614-98546477 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022919	protein coding gene	Chr16:110548250-110566562 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0023525	protein coding gene	Chr16:97643075-97673388 (-)
PWK/PhJ	MGP_PWKPhJ_G0022085	protein coding gene	Chr16:94386664-94408972 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021915	protein coding gene	Chr16:97157437-97179038 (-)
WSB/EiJ	MGP_WSBEiJ_G0022391	protein coding gene	Chr16:97930415-97951771 (-)

Human Ortholog

MX1, MX dynamin like GTPase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MX1, MX dynamin like GTPase 1
Synonyms

IFI78, IFI-78K, lncMX1-215, MX, MxA
Links

HGNC:7532

NCBI Gene ID: 4599

neXtProt AC: NX_P20591

UniProt: P20591
Chr Location

21q22.3; chr21:41420020-41470071 (+) GRCh38

Human Ortholog

MX2, MX dynamin like GTPase 2
Synonyms

MXB
Links

HGNC:7533

NCBI Gene ID: 4600

neXtProt AC: NX_P20592

UniProt: P20592
Chr Location

21q22.3; chr21:41361999-41409393 (+) GRCh38

MGI Vertebrate Homology

Mx1 stringent orthology
2 human;1 mouse
HCOP

vertebrate homology predictions: MX1, MX2
Gene Tree

Mx1

Diseases

4 with human MX1 associations

				Human Disease	Mouse Models
				alopecia areata IDs alopecia areata DOID:986 EFO:0004192 ICD10CM:L63 ICD9CM:704.01 MESH:D000506 OMIM:104000 OMIM:610753 UMLS_CUI:C0002171
				avian influenza IDs avian influenza DOID:4492 ICD10CM:J09.X MESH:D005585 UMLS_CUI:C0016627
				liver disease IDs liver disease DOID:409 DOID:2164 DOID:2165 DOID:46 ICD10CM:K76.9 ICD9CM:573.9 MESH:D008107 NCI:C3196 UMLS_CUI:C0023895
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

References

6 with disease annotations

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Phenotype Summary

8 phenotypes from 4 alleles in 8 genetic backgrounds
4 phenotypes from multigenic genotypes
159 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Endonuclease-mediated

2
Gene trapped

1
Spontaneous

4
Targeted

7
Genomic Mutations

6 involving Mx1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

81 strains or lines available
Recombinase Activity

Comparison Matrix Gene Expression + Recombinase Activity

A2G, SL/NiA, T9 and CAST/Ei strains produce the MX1 protein (Mx1+ allele) conferring resistance to myxoviruses, whereas no protein is made by the Mx1- susceptible alleles of C57BL/6J and many other inbred strains with an exon 9-11 deletion; or CBA/J, CE/J, I/LnJ and PERA/Ei with a nonsense mutation.

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All GO Annotations

15
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

733
Tissues

21
cDNA Data

29
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

69
RefSeq

3
UniProt

11

Ensembl

ENSMUSG00000000386 (Evidence)
NCBI Gene

17857

			Length	Strain/Species	Flank
genomic	17857	NCBI Gene Model \| MGI Sequence Detail	15872	C57BL/6J	± kb
transcript	NM_010846	RefSeq \| MGI Sequence Detail	3218	BALB.A2G-Mx1
polypeptide	P09922	UniProt \| EBI \| MGI Sequence Detail	631	Not Applicable

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UniProt

11 Sequences
InterPro Domains

IPR022812 Dynamin

IPR001401 Dynamin, GTPase domain

IPR003130 Dynamin GTPase effector

IPR019762 Dynamin, GTPase region, conserved site

IPR045063 Dynamin, N-terminal

IPR000375 Dynamin stalk domain

IPR030381 Dynamin-type guanine nucleotide-binding (G) domain

IPR020850 GTPase effector domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 47

Genomic 10

cDNA 29

Primer pair 6

Other 2

Microarray probesets 3

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MGD-MRK-12725, MGD-MRK-12726, MGD-MRK-12728, MGI:2146518

Summaries

All 241

Developmental Gene Expression 5

Diseases 6

Gene Ontology 3

Phenotypes 159
Earliest

J:13136 LINDENMANN J, INHERITANCE OF RESISTANCE TO INFLUENZA VIRUS IN MICE. Proc Soc Exp Biol Med. 1964 Jun;116:506-9
Latest

J:357723 Sirbulescu RF, et al., Allogeneic B cell immunomodulatory therapy in amyotrophic lateral sclerosis. FASEB J. 2024 Jul 15;38(13):e23796

TSS for Mx1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr142322	Chr16:97264103-97264108 (-)	0 bp
Tssr142321	Chr16:97262680-97262702 (-)	1,415 bp
Tssr142320	Chr16:97261681-97261691 (-)	2,420 bp
Tssr142319	Chr16:97261081-97261099 (-)	3,016 bp
Tssr142318	Chr16:97261047-97261061 (-)	3,052 bp
Tssr142317	Chr16:97260797-97260821 (-)	3,297 bp
Tssr142316	Chr16:97260708-97260731 (-)	3,386 bp
Tssr142315	Chr16:97260362-97260374 (-)	3,738 bp
Tssr142314	Chr16:97260181-97260191 (-)	3,920 bp
Tssr142313	Chr16:97255442-97255454 (-)	8,658 bp
Tssr142312	Chr16:97255410-97255424 (-)	8,689 bp
Tssr142311	Chr16:97255215-97255230 (-)	8,883 bp
Tssr142310	Chr16:97254068-97254078 (-)	10,033 bp
Tssr142309	Chr16:97251605-97251619 (-)	12,494 bp
Tssr142308	Chr16:97248860-97248864 (-)	15,244 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/10/2024 MGI 6.24