Mx2 MGI Mouse Pseudogene Detail - MGI:97244 - MX dynamin-like GTPase 2

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Mx2 Pseudogene Detail

Symbol

Mx2
Name

MX dynamin-like GTPase 2
Synonyms

Mx-2

Feature Type

polymorphic pseudogene

BioType Conflict
IDs

MGI:97244
NCBI Gene: 17858
Alliance

gene page
Transcription Start Sites

26 TSS

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Sequence Map

Chr16:97337281-97362101 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 57.51 cM
Mapping Data

2 experiments

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SNPs within 2kb

549 from dbSNP Build 142
Strain Annotations

15
RFLP

1

Strain-Specific Marker

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_97244	polymorphic pseudogene	Chr16:97336508-97362101 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0009937	polymorphic pseudogene	Chr16:98975321-99001926 (+)
A/J	MGP_AJ_G0009921	polymorphic pseudogene	Chr16:94306282-94333178 (+)
AKR/J	no annotation
BALB/cJ	MGP_BALBcJ_G0009906	polymorphic pseudogene	Chr16:94852897-94879920 (+)
C3H/HeJ	MGP_C3HHeJ_G0009838	polymorphic pseudogene	Chr16:97732722-97759089 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0010152	polymorphic pseudogene	Chr16:102065499-102096467 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0008949	polymorphic pseudogene	Chr16:92139309-92168414 (+)
CAST/EiJ	MGP_CASTEiJ_G0009656	polymorphic pseudogene	Chr16:98540562-98573150 (+)
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0009839	polymorphic pseudogene	Chr16:94165560-94193426 (+)
FVB/NJ	MGP_FVBNJ_G0009856	polymorphic pseudogene	Chr16:93326378-93353473 (+)
LP/J	MGP_LPJ_G0009934	polymorphic pseudogene	Chr16:98621960-98651094 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0009823	polymorphic pseudogene	Chr16:110647208-110674730 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0010125	polymorphic pseudogene	Chr16:97756736-97786036 (+)
PWK/PhJ	MGP_PWKPhJ_G0009577	polymorphic pseudogene	Chr16:94506985-94522251 (+)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0009758	polymorphic pseudogene	Chr16:98025523-98054325 (+)

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Human Ortholog

MX1, MX dynamin like GTPase 1

Vertebrate Orthologs

8

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MX1, MX dynamin like GTPase 1
Synonyms

IFI78, IFI-78K, lncMX1-215, MX, MxA
Links

HGNC:7532

NCBI Gene ID: 4599

neXtProt AC: NX_P20591

UniProt: P20591
Chr Location

21q22.3; chr21:41420020-41470071 (+) GRCh38

Human Ortholog

MX2, MX dynamin like GTPase 2
Synonyms

MXB
Links

HGNC:7533

NCBI Gene ID: 4600

neXtProt AC: NX_P20592

UniProt: P20592
Chr Location

21q22.3; chr21:41361999-41409393 (+) GRCh38

MGI Vertebrate Homology

Mx2 stringent orthology
2 human;1 mouse;1 rat;5 zebrafish
HCOP

vertebrate homology predictions: MX1, MX2
Gene Tree

Mx2

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Diseases

4 with human MX1 associations

				Human Disease	Mouse Models
				alopecia areata IDs alopecia areata DOID:986 EFO:0004192 ICD10CM:L63 ICD9CM:704.01 MESH:D000506 OMIM:104000 OMIM:610753 UMLS_CUI:C0002171
				avian influenza IDs avian influenza DOID:4492 ICD10CM:J09.X MESH:D005585 UMLS_CUI:C0016627
				liver disease IDs liver disease DOID:409 DOID:2164 DOID:2165 DOID:46 ICD10CM:K76.9 ICD9CM:573.9 MESH:D008107 NCI:C3196 UMLS_CUI:C0023895
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

2
Targeted

4
Genomic Mutations

5 involving Mx2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

21 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mx1+ strains do not express MX2 protein. The Mx2 gene in BALB/cJ and CBA/J is interrupted by an open reading frame mutation. Mutagenesis correcting the frameshift permits Mx2 expression in 3T3 cells. This protein did not inhibit influenza virus but conferred resistance to vesicular stomatitis virus.

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All GO Annotations

29
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

913
Tissues

65
cDNA Data

29
Literature Summary

3

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

41
RefSeq

3
UniProt

4

Ensembl

ENSMUSG00000023341 (Evidence)
NCBI Gene

17858

Representative Sequences				Length	Strain/Species	Flank
	genomic	17858	NCBI Gene Model \| MGI Sequence Detail	24821	C57BL/6J	± kb
	transcript	NR_003508	RefSeq \| MGI Sequence Detail	2428	ZRU/MplStud
	polypeptide	Q9WVP9	UniProt \| EBI \| MGI Sequence Detail	655	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010788 interferon-induced GTP-binding protein Mx1

(term hierarchy)
InterPro Domains

IPR022812 Dynamin

IPR001401 Dynamin, GTPase domain

IPR003130 Dynamin GTPase effector

IPR019762 Dynamin, GTPase region, conserved site

IPR045063 Dynamin, N-terminal

IPR000375 Dynamin stalk domain

IPR030381 Dynamin-type guanine nucleotide-binding (G) domain

IPR020850 GTPase effector domain

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 32

cDNA 29

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-12727, MGD-MRK-12729, MGI:2146454

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Summaries

All 56

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 15
Earliest

J:13136 LINDENMANN J, INHERITANCE OF RESISTANCE TO INFLUENZA VIRUS IN MICE. Proc Soc Exp Biol Med. 1964 Jun;116:506-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mx2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr139688	Chr16:97336490-97336519 (+)	-776 bp
Tssr139689	Chr16:97337279-97337285 (+)	1 bp
Tssr139690	Chr16:97337538-97337546 (+)	261 bp
Tssr139691	Chr16:97342699-97342710 (+)	5,424 bp
Tssr139692	Chr16:97345091-97345101 (+)	7,815 bp
Tssr139693	Chr16:97348510-97348517 (+)	11,233 bp
Tssr139694	Chr16:97348732-97348740 (+)	11,455 bp
Tssr139695	Chr16:97349804-97349819 (+)	12,531 bp
Tssr139696	Chr16:97349822-97349841 (+)	12,551 bp
Tssr139697	Chr16:97349889-97349905 (+)	12,616 bp
Tssr139698	Chr16:97349919-97349934 (+)	12,646 bp
Tssr139699	Chr16:97349935-97349964 (+)	12,669 bp
Tssr139700	Chr16:97349990-97350016 (+)	12,722 bp
Tssr139701	Chr16:97351687-97351727 (+)	14,426 bp
Tssr139702	Chr16:97352063-97352075 (+)	14,788 bp
Tssr139703	Chr16:97353168-97353191 (+)	15,899 bp
Tssr139704	Chr16:97355228-97355232 (+)	17,949 bp
Tssr139705	Chr16:97355832-97355845 (+)	18,558 bp
Tssr139706	Chr16:97356240-97356247 (+)	18,963 bp
Tssr139707	Chr16:97358947-97358960 (+)	21,673 bp
Tssr139708	Chr16:97358993-97359007 (+)	21,719 bp
Tssr139709	Chr16:97359083-97359092 (+)	21,807 bp
Tssr139710	Chr16:97359111-97359122 (+)	21,836 bp
Tssr139711	Chr16:97359223-97359237 (+)	21,949 bp
Tssr139712	Chr16:97359269-97359283 (+)	21,995 bp
Tssr139713	Chr16:97359284-97359299 (+)	22,011 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24